Schreiber, Stuart L.

Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia

Sykes, D. B., Kfoury, Y. S., Mercier, F. E., Wawer, M. J., Law, J. M., Haynes, M. K., Lewis, T. A., Schajnovitz, A., Jain, E., Lee, D., et al. (2016) · Cell

Acute Myeloid Leukemia ResearchBiochemical and Molecular Research

Cited by 500

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 416

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Lassen, K. G., Kuballa, P., Conway, K. L., Patel, K. K., Becker, C. E., Peloquin, J. M., Villablanca, E. J., Norman, J. M., Liu, T.-C., Heath, R. J., et al. (2014) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyInflammatory Bowel Disease

Cited by 373

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

Hassig, C. A., Tong, J. K., Fleischer, T. C., Owa, T., Grable, P. G., Ayer, D. E., & Schreiber, S. L. (1998) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 365

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Yu, C., Mannan, A. M., Yvone, G. M., Ross, K. N., Zhang, Y.-L., Marton, M. A., Taylor, B. R., Crenshaw, A., Gould, J. Z., Tamayo, P., et al. (2016) · Nature Biotechnology

Cancer Genomics and DiagnosticsComputational Drug Discovery Methods

Cited by 362

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Vinogradova, E. V., Zhang, X., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., et al. (2020) · Cell

Redox biology and oxidative stressGenomics, phytochemicals, and oxidative stress

Cited by 351

Small molecules: the missing link in the central dogma

Schreiber, S. L. (2005) · Nature Chemical Biology

Click Chemistry and ApplicationsBiochemical and Molecular Research

Cited by 306

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

Gustafsdottir, S. M., Ljosa, V., Sokolnicki, K. L., Anthony Wilson, J., Walpita, D., Kemp, M. M., Petri Seiler, K., Carrel, H. A., Golub, T. R., Schreiber, S. L., et al. (2013) · PLoS ONE

Cell Image Analysis TechniquesComputational Drug Discovery Methods

Cited by 291

ATR inhibition selectively sensitizes G 1 checkpoint-deficient cells to lethal premature chromatin condensation

Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 290

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Cimprich, K. A., Shin, T. B., Keith, C. T., & Schreiber, S. L. (1996) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 273

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Haggarty, S. J., Mayer, T. U., Miyamoto, D. T., Fathi, R., King, R. W., Mitchison, T. J., & Schreiber, S. L. (2000) · Chemistry & Biology

Microtubule and mitosis dynamicsHeterocyclic Compound Synthesis and Bioactivity

Cited by 251

Perturbational profiling of nanomaterial biologic activity

Shaw, S. Y., Westly, E. C., Pittet, M. J., Subramanian, A., Schreiber, S. L., & Weissleder, R. (2008) · Proceedings of the National Academy of Sciences

Nanoparticles: synthesis and applicationsImmunotoxicology and immune responses

Cited by 248

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Weïwer, M., Bittker, J. A., Lewis, T. A., Shimada, K., Yang, W. S., MacPherson, L., Dandapani, S., Palmer, M., Stockwell, B. R., Schreiber, S. L., et al. (2012) · Bioorganic & Medicinal Chemistry Letters

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 237

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Li, H., Bullock, K., Gurjao, C., Braun, D., Shukla, S. A., Bossé, D., Lalani, A.-K. A., Gopal, S., Jin, C., Horak, C., et al. (2019) · Nature Communications

Cancer Immunotherapy and BiomarkersTryptophan and brain disorders

Cited by 218

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, J. E., Mak, R., Tanguturi, S. K., Mazitschek, R., Haggarty, S. J., Ross, K., Chang, C. Y., Bosco, J., West, N., Morse, E., et al. (2010) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHistone Deacetylase Inhibitors Research

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A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

Alvarez, M. J., Subramaniam, P. S., Tang, L. H., Grunn, A., Aburi, M., Rieckhof, G., Komissarova, E. V., Hagan, E. A., Bodei, L., Clemons, P. A., et al. (2018) · Nature Genetics

Neuroendocrine Tumor Research AdvancesNeuroblastoma Research and Treatments

Cited by 210

Unifying principles of bifunctional, proximity-inducing small molecules

Gerry, C. J., & Schreiber, S. L. (2020) · Nature Chemical Biology

Protein Degradation and InhibitorsBiotin and Related Studies

Cited by 199

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

Wawer, M. J., Li, K., Gustafsdottir, S. M., Ljosa, V., Bodycombe, N. E., Marton, M. A., Sokolnicki, K. L., Bray, M.-A., Kemp, M. M., Winchester, E., et al. (2014) · Proceedings of the National Academy of Sciences

Computational Drug Discovery MethodsCell Image Analysis Techniques

Cited by 196

Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

Bowers, A., West, N., Taunton, J., Schreiber, S. L., Bradner, J. E., & Williams, R. M. (2008) · Journal of the American Chemical Society

Histone Deacetylase Inhibitors ResearchHeterocyclic Compound Synthesis and Bioactivity

Cited by 165

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Rusu, V., Hoch, E., Mercader, J. M., Tenen, D. E., Gymrek, M., Hartigan, C. R., DeRan, M., von Grotthuss, M., Fontanillas, P., Spooner, A., et al. (2017) · Cell

Genetic Associations and EpidemiologyMetabolism, Diabetes, and Cancer

Cited by 152

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line

Albers, M. W., Williams, R. T., Brown, E. J., Tanaka, A., Hall, F. L., & Schreiber, S. L. (1993) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

Cited by 145

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

Hung, D. T., Chen, J., & Schreiber, S. L. (1996) · Chemistry & Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 141

Molecular glues and bifunctional compounds: Therapeutic modalities based on induced proximity

Schreiber, S. L. (2024) · Cell Chemical Biology

Protein Degradation and InhibitorsChemical Synthesis and Analysis

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