Oxidative stress inhibits healthy adipose expansion through suppression of SREBF1-mediated Lipogenic pathway
Open accessAbstract
Recent studies have emphasized the association of adipose oxidative stress (Fat reactive oxygen species [ROS]) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stress is manipulated by targeting adipocytes. In this research, we generated two models of Fat ROS–manipulated mice and evaluated the metabolic features in diet-induced obesity. Fat ROS–eliminated mice, in which Cat and Sod1 were overexpressed in adipocytes, exhibited adipose expansion with decreased ectopic lipid accumulation and improved insulin sensitivity. Conversely, Fat ROS–augmented mice, in which glutathione was depleted specifically in adipocytes, exhibited restricted adipose expansion associated with increased ectopic lipid accumulation and deteriorated insulin sensitivity. In the white adipose tissues of these mice, macrophage polarization, tissue fibrosis, and de novo lipogenesis were significantly changed. In vitro approaches identified KDM1A-mediated attenuation of sterol-regulatory element-binding transcription factor 1 (SREBF1) transcriptional activities as the underlying mechanism for the suppression of de novo lipogenesis by oxidative stress. Thus, our study uncovered the novel roles of Fat ROS in healthy adipose expansion, ectopic lipid accumulation, and insulin resistance, providing the possibility for the adipocyte-targeting antioxidant therapy.
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Numerous scientific investigations have substantiated a robust correlation between hyperlipidemia and oxidative stress, with oxidative stress assuming a pivotal role in the development of metabolic disorders.
“Numerous scientific investigations have substantiated a robust correlation between hyperlipidemia and oxidative stress, with oxidative stress assuming a pivotal role in the development of metabolic disorders (Le Lay et al., 2014; Okuno et al., 2018; Raut and Khullar, 2023).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Okuno et al., 2018
The Discussion (page unavailable) reports that increased adipose oxidative stress led to ectopic lipid accumulation and worsened insulin sensitivity in mice, supporting a role in metabolic dysfunction. The paper does not establish the claimed robust correlation between hyperlipidemia and oxidative stress; ectopic lipid accumulation is not the same as elevated blood lipids. (LLM, conf=0.85)
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,086 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898 · see citing works
Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396 · see citing works
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · cited 1× · see citing works
“Recent studies have demonstrated that such changes are preceded by various changes inWAT, such as infiltration of inflammatory cells (5), endoplasmic reticulum stress (6), hypoxia (7), and oxidative stress (8).”
BackgroundAnderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062 · see citing works
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Bonora, E., Kiechl, S. J., Willeit, J., Oberhollenzer, F., Egger, G., Targher, G., Alberiche, M., Bonadonna, R. C., & Muggeo, M. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1643 · Cited by 833 · see citing works
Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790 · see citing works
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668 · see citing works
Transcriptional Control of Adipose Lipid Handling by IRF4
Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 607 · see citing works
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Herman, M. A., Peroni, O. D., Villoria, J., Schön, M. R., Abumrad, N. A., Blüher, M., Klein, S., & Kahn, B. B. (2012) · Nature · doi:10.1038/nature10986 · Cited by 599 · see citing works
The metabolically healthy but obese individual presents a favorable inflammation profile
Karelis, A. D., Faraj, M., Bastard, J.-P., St-Pierre, D. H., Brochu, M., Prud’homme, D., & Rabasa-Lhoret, R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0482 · Cited by 579 · see citing works
Insulin resistance is a cellular antioxidant defense mechanism
Hoehn, K. L., Salmon, A. B., Hohnen-Behrens, C., Turner, N., Hoy, A. J., Maghzal, G. J., Stocker, R., Van Remmen, H., Kraegen, E. W., Cooney, G. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902380106 · Cited by 540 · see citing works
Kusminski, C. M., Holland, W. L., Sun, K., Park, J., Spurgin, S. B., Lin, Y., Askew, G. R., Simcox, J., McClain, D. A., Li, C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2899 · Cited by 466 · see citing works
Are there persons who are obese, but metabolically healthy?
Sims, E. A. H. (2001) · Metabolism · doi:10.1053/meta.2001.27213 · Cited by 454 · see citing works
Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K. (2012) · Scientific Reports · doi:10.1038/srep00799 · Cited by 404 · see citing works
Amemiya-Kudo, M., Shimano, H., Hasty, A. H., Yahagi, N., Yoshikawa, T., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., et al. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m100417-jlr200 · Cited by 398 · see citing works
Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L., Roth, K. A., Kitsis, R. N., & Scherer, P. E. (2005) · Nature Medicine · doi:10.1038/nm1262 · Cited by 322 · see citing works
Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.004 · Cited by 319 · see citing works
Kelly, I. E., Han, T. S., Walsh, K., & Lean, M. E. J. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.288 · Cited by 314 · see citing works
Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome
Fujita, K., Nishizawa, H., Funahashi, T., Shimomura, I., & Shimabukuro, M. (2006) · Circulation Journal · doi:10.1253/circj.70.1437 · Cited by 294 · see citing works
Inoue, I., Goto, S.-I., Matsunaga, T., Nakajima, T., Awata, T., Hokari, S., Komoda, T., & Katayama, S. (2001) · Metabolism · doi:10.1053/meta.2001.19415 · Cited by 283 · see citing works
Hardy, O. T., Perugini, R. A., Nicoloro, S. M. C., Gallagher-Dorval, K. A., Puri, V., Straubhaar, J., & Czech, M. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.05.013 · Cited by 225 · see citing works
Stoeckman, A. K., Ma, L., & Towle, H. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311301200 · Cited by 218 · see citing works
Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H. L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., Denis, R. G. P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3829 · Cited by 205 · see citing works
Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis
Tanaka, M., Ikeda, K., Suganami, T., Komiya, C., Ochi, K., Shirakawa, I., Hamaguchi, M., Nishimura, S., Manabe, I., Matsuda, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5982 · Cited by 201 · see citing works
Pelton, P. D., Zhou, L., Demarest, K. T., & Burris, T. P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1071 · Cited by 186 · see citing works
The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells
Wu, Y., Wang, Y., Yang, X. H., Kang, T., Zhao, Y., Wang, C., Evers, B. M., & Zhou, B. P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.030 · Cited by 171 · see citing works
Kurata, A., Nishizawa, H., Kihara, S., Maeda, N., Sonoda, M., Okada, T., Ohashi, K., Hibuse, T., Fujita, K., Yasui, A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001810 · Cited by 166 · see citing works
Flow Cytometry Analyses of Adipose Tissue Macrophages
Cho, K. W., Morris, D. L., & Lumeng, C. N.-K. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-411619-1.00016-1 · Cited by 118 · see citing works
Okuno, Y., Matsuda, M., Miyata, Y., Fukuhara, A., Komuro, R., Shimabukuro, M., & Shimomura, I. (2010) · Endocrine Journal · doi:10.1507/endocrj.k09e-113 · Cited by 112 · see citing works
Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development
Han, X., Gui, B., Xiong, C., Zhao, L., Liang, J., Sun, L., Yang, X., Yu, W., Si, W., Yan, R., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.006 · Cited by 102 · see citing works
Hirata, A., Maeda, N., Nakatsuji, H., Hiuge-Shimizu, A., Okada, T., Funahashi, T., & Shimomura, I. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.139 · Cited by 88 · see citing works
Liu, Y., Qi, W., Richardson, A. G., Remmen, H. V., Ikeno, Y., & Salmon, A. B. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.029 · Cited by 73 · see citing works
Adipose expression of catalase is regulated via a novel remote PPARγ-responsive region
Okuno, Y., Matsuda, M., Kobayashi, H., Morita, K., Suzuki, E., Fukuhara, A., Komuro, R., Shimabukuro, M., & Shimomura, I. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.001 · Cited by 69 · see citing works
Lipid metabolism and body composition in Gclm(−/−) mice
Kendig, E. L., Chen, Y., Krishan, M., Johansson, E., Schneider, S. N., Genter, M. B., Nebert, D. W., & Shertzer, H. G. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.09.017 · Cited by 64 · see citing works
Fat distribution in men of different waist girth, fitness level and exercise habit
O’Donovan, G., Thomas, E. L., McCarthy, J. P., Fitzpatrick, J. A., Durighel, G., Mehta, S., Morin, S. H., Goldstone, A. P., & Bell, J. D. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.189 · Cited by 53 · see citing works
Glutathione Decrement Drives Thermogenic Program In Adipose Cells
Lettieri‐Barbato, D., Tatulli, G., Cannata, S. M., Bernardini, S., Aquilano, K., & Ciriolo, M. R. (2015) · Scientific Reports · doi:10.1038/srep13091 · Cited by 47 · see citing works
Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species
Guo, W., Xie, W., & Han, J. (2006) · Nutrition & Metabolism · doi:10.1186/1743-7075-3-30 · Cited by 41 · see citing works
Regulation of Lipogenic Gene Expression by Lysine-specific Histone Demethylase-1 (LSD1)
Abdulla, A., Zhang, Y., Hsu, F.-N., Xiaoli, A. M., Zhao, X., Yang, E. S. T., Ji, J., & Yang, F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573659 · Cited by 39 · see citing works
Expression of activating transcription factor 2 in inflammatory macrophages in obese adipose tissue
Miyata, Y., Fukuhara, A., Otsuki, M., & Shimomura, I. (2013) · Obesity · doi:10.1002/oby.20274 · Cited by 32 · see citing works
Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles
Elshorbagy, A. K., Jernerén, F., Scudamore, C. L., McMurray, F., Cater, H. L., Hough, T., Cox, R., & Refsum, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163214 · Cited by 20 · see citing works
Okauchi, Y., Kishida, K., Funahashi, T., Noguchi, M., Ogawa, T., Okita, K., Iwahashi, H., Ohira, T., Imagawa, A., Nakamura, T., et al. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-82 · Cited by 19 · see citing works
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Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis
Marcelin, G., Silveira, A. L. M., Martins, L. B., Ferreira, A. V. M., & Clément, K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129192 · Cited by 274 · see citing works
Obesity and ageing: Two sides of the same coin
Tam, B. T., Morais, J. A., & Santosa, S. (2020) · Obesity Reviews · doi:10.1111/obr.12991 · Cited by 254 · see citing works
The Impact of Oxidative Stress on Adipose Tissue Energy Balance
Masschelin, P. M., Cox, A. R., Chernis, N., & Hartig, S. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01638 · Cited by 200 · see citing works
Adipose Tissue Fibrosis in Obesity: Etiology and Challenges
Marcelin, G., Gautier, E. L., & Clément, K. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092930 · Cited by 185 · see citing works
Gorwood, J., Bourgeois, C., Pourcher, V., Pourcher, G., Charlotte, F., Mantecon, M., Rose, C., Morichon, R., Atlan, M., Grand, R. L., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa259 · Cited by 158 · see citing works
Abildgaard, J., Ploug, T., Al-Saoudi, E., Wagner, T., Thomsen, C., Ewertsen, C., Bzorek, M., Pedersen, B. K., Pedersen, A. T., & Lindegaard, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-94189-2 · Cited by 116 · see citing works
Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
Маслов, Л. Н., Naryzhnaya, N. V., Boshchenko, A. A., Popov, S. V., Ivanov, V. V., & Oeltgen, P. R. (2018) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2018.11.001 · Cited by 111 · see citing works
The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity
Zhou, Y., Li, H., & Xia, N. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650214 · Cited by 106 · see citing works
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Peña‐Oyarzún, D., Bravo, R., Díaz‐Vegas, A., Aleman, L., Chiong, M., Garcı́a, L., Claudia Bambs, S., Troncoso, R., Cifuentes, M., Morselli, E., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.084 · Cited by 101 · see citing works
DeVallance, E., Li, Y., Jurczak, M. J., Cifuentes-Pagano, E., & Pagano, P. J. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7674 · Cited by 99 · see citing works
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
Verkerke, A. R. P., Wang, D., Yoshida, N., Taxin, Z. H., Shi, X., Zheng, S., Li, Y., Auger, C., Oikawa, S., Yook, J.-S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.030 · Cited by 104 · see citing works
The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy
Assumpção, J. A. F., Pasquarelli-do-Nascimento, G., Viegas, M. S., Bonamino, M., & Magalhães, K. G. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00796-0 · Cited by 94 · see citing works
Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders
Kleiboeker, B. A., & Lodhi, I. J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101577 · Cited by 93 · see citing works
Zinc Supplementation Alleviates Lipid and Glucose Metabolic Disorders Induced by a High-Fat Diet
Qi, Y., Zhang, Z., Liu, S., Aluo, Z., Zhang, L., Yu, L., Li, Y., Song, Z., & Zhou, L. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01103 · Cited by 77 · see citing works
Pharmacology of apocynin: a natural acetophenone
Savla, S. R., Laddha, A. P., & Kulkarni, Y. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1895203 · Cited by 76 · see citing works
Zhou, J., Zhang, N., Aldhahrani, A., Soliman, M. M., Zhang, L., & Zhou, F. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.956688 · Cited by 70 · see citing works
Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D., & Scherer, P. E. (2019) · JCI Insight · doi:10.1172/jci.insight.129397 · Cited by 66 · see citing works
Peroxisomal regulation of redox homeostasis and adipocyte metabolism
Liu, J., Lu, W., Shi, B., Klein, S., & Su, X. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101167 · Cited by 64 · see citing works
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression
Asantewaa, G., Tuttle, E. T., Ward, N. P., Kang, Y. P., Kim, Y., Kavanagh, M. E., Girnius, N., Chen, Y., Rodriguez, K., Hecht, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50454-2 · Cited by 63 · see citing works
Sakane, S., Hikita, H., Shirai, K., Myojin, Y., Sasaki, Y., Kudo, S., Fukumoto, K., Mizutani, N., Tahata, Y., Makino, Y., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.07.008 · Cited by 61 · see citing works
Xiao, L., Zhang, T., Geng, J., Wu, Z., Xu, L., Liu, J., Tian, J., Zhou, Z., Nie, J., & Bai, X. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7634 · Cited by 60 · see citing works
Redox Regulation of Lipid Mobilization in Adipose Tissues
Abou-Rjeileh, U., & Contreras, G. A. (2021) · Antioxidants · doi:10.3390/antiox10071090 · Cited by 56 · see citing works
Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes
Mihaylova, L. V., Savova, M. S., Tews, D., Wabitsch, M., & Georgiev, M. I. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112002 · Cited by 52 · see citing works
Cheng, M., Ding, F., Li, L., Dai, C., Sun, X., Xu, J., Chen, F., Li, M., & Li, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1517174 · Cited by 49 · see citing works
Pruett, J. E., Everman, S. J., Hoang, N., Salau, F., Taylor, L. C., Edwards, K. S., Hosler, J. P., Huffman, A. M., Romero, D. G., & Cardozo, L. L. Y. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00455-x · Cited by 46 · see citing works
Yu, Y., Dong, J.-T., He, B., Zou, Y., Li, X., Xi, C.-H., & Yu, Y. (2019) · Future Oncology · doi:10.2217/fon-2019-0321 · Cited by 46 · see citing works
The pivotal role of Nrf2 activators in adipocyte biology
Annie-Mathew, A. S., Prem-Santhosh, S., Jayasuriya, R., Ganesh, G., Ramkumar, K. M., & Sarada, D. V. L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105853 · Cited by 49 · see citing works
Current Status of Obesity: Protective Role of Catechins
Basu, T., Selman, A., Reddy, A. P., & Reddy, P. H. (2023) · Antioxidants · doi:10.3390/antiox12020474 · Cited by 45 · see citing works
Liu, J., Li, X., Chen, J., Zhang, X., Guo, J., Gu, J., Mei, C., Xiao, Y., Peng, C., Liu, J., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c14962 · Cited by 44 · see citing works
Eye on the horizon: The metabolic landscape of the RPE in aging and disease
Hansman, D., Du, J., Casson, R. J., & Peet, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101306 · Cited by 48 · see citing works
A review of dolutegravir-associated weight gain and secondary metabolic comorbidities
Jemal, M. (2024) · SAGE Open Medicine · doi:10.1177/20503121241260613 · Cited by 44 · see citing works
Wan, X., Chen, J., Wang, M., Zheng, C., & Zhou, X.-L. (2021) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2021.111521 · Cited by 43 · see citing works
Janson, B., Prasomthong, J., Malakul, W., Boonsong, T., & Tunsophon, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111438 · Cited by 41 · see citing works
Chen, Y., He, L., Yang, Y., Chen, Y., Song, Y., Lu, X., & Liang, Y. (2019) · Renal Failure · doi:10.1080/0886022x.2019.1655450 · Cited by 40 · see citing works
Nankam, P. A. N., Nguelefack, T. B., Goedecke, J. H., & Blüher, M. (2021) · Antioxidants · doi:10.3390/antiox10040622 · Cited by 41 · see citing works
Gorwood, J., Ejlalmanesh, T., Bourgeois, C., Mantecon, M., Rose, C., Atlan, M., Desjardins, D., Grand, R. L., Fève, B., Lambotte, O., et al. (2020) · Cells · doi:10.3390/cells9040854 · Cited by 38 · see citing works
Nakamura, Y., Abe, M., Kawasaki, K., Miyake, T., Watanabe, T., Yoshida, O., Hirooka, M., Matsuura, B., & Hiasa, Y. (2019) · Scientific Reports · doi:10.1038/s41598-018-37403-y · Cited by 34 · see citing works
Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases
Moroni-González, D., Sarmiento-Ortega, V. E., Díaz, A., Brambila, E., & Treviño, S. (2023) · Toxics · doi:10.3390/toxics11030223 · Cited by 34 · see citing works
Role of reactive oxygen species in regulating epigenetic modifications
Chen, Y., & Shen, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111502 · Cited by 31 · see citing works
Ketone body 3-hydroxybutyrate enhances adipocyte function
Nishitani, S., Fukuhara, A., Tomita, I., Kume, S., Shin, J., Okuno, Y., Otsuki, M., Maegawa, H., & Shimomura, I. (2022) · Scientific Reports · doi:10.1038/s41598-022-14268-w · Cited by 30 · see citing works
Fight against fibrosis in adipose tissue remodeling
Li, S., Gao, H., Hasegawa, Y., & Lü, X. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00558.2020 · Cited by 29 · see citing works
Reversing the Genomic, Epigenetic, and Triple-Negative Breast Cancer–Enhancing Effects of Obesity
Bowers, L. W., Doerstling, S. S., Shamsunder, M. G., Lineberger, C. G., Rossi, E. L., Montgomery, S. A., Coleman, M. F., Gong, W., Parker, J. S., Howell, A., et al. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-22-0113 · Cited by 29 · see citing works
Arivazhagan, L., Ruiz, H. H., Wilson, R. A., Manigrasso, M. B., Gugger, P. F., Fisher, E. A. A., Moore, K. J., Ramasamy, R., & Schmidt, A. M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315900 · Cited by 25 · see citing works
Lake, J. E., Moser, C., Johnston, L., Magyar, C. E., Nelson, S. D., Erlandson, K. M., Brown, T. T., & McComsey, G. A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02785 · Cited by 24 · see citing works
Tyrosol May Prevent Obesity by Inhibiting Adipogenesis in 3T3-L1 Preadipocytes
Pacifici, F., Farias, C. L. A., Rea, S., Capuani, B., Feraco, A., Coppola, A., Mammi, C., Pastore, D., Abete, P., Rovella, V., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4794780 · Cited by 23 · see citing works
Paroni, G., Zanetti, A., Barzago, M. M., Kurosaki, M., Guarrera, L., Fratelli, M., Troiani, M., Ubezio, P., Bolis, M., Vallerga, A., et al. (2020) · Cancers · doi:10.3390/cancers12103027 · Cited by 22 · see citing works
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors
Okuno, Y., Fukuhara, A., Otsuki, M., & Shimomura, I. (2022) · JCI Insight · doi:10.1172/jci.insight.151390 · Cited by 25 · see citing works
Saaoud, F., Wang, J., Iwanowycz, S., Wang, Y., Altomare, D., Shao, Y., Liu, J., Blackshear, P. J., Lessner, S. M., Murphy, E. A., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101609 · Cited by 22 · see citing works
MicroRNA-325 facilitates atherosclerosis progression by mediating the SREBF1/LXR axis via KDM1A
Pu, Y., Zhao, Q. L., Men, X., Jin, W., & Yang, M. H. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119464 · Cited by 21 · see citing works
Qi, Y., Zhang, H., Fan, H., Wang, X., Zhao, A., Tian, Y., Yang, G., Li, C. R., Wei, J., Yao, W., et al. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118272 · Cited by 21 · see citing works
Toyoda, S., Shin, J., Fukuhara, A., Otsuki, M., & Shimomura, I. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101748 · Cited by 21 · see citing works
Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats
Nour, O. A., Ghoniem, H. A., Nader, M. A., & Suddek, G. M. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174257 · Cited by 20 · see citing works
Ipragliflozin Ameliorates Diabetic Nephropathy Associated with Perirenal Adipose Expansion in Mice
Okuma, H., Mori, K., Nakamura, S., Sekine, T., Ogawa, Y., & Tsuchiya, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147329 · Cited by 20 · see citing works
Obesity and Exercise: New Insights and Perspectives
James, N. M., & Stanford, K. I. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf017 · Cited by 20 · see citing works
Identification of SCARA3 with potential roles in metabolic disorders
Peng, H., Guo, Q., Su, T., Xiao, Y., Li, C., Huang, Y., & Luo, X. (2020) · Aging · doi:10.18632/aging.202228 · Cited by 19 · see citing works
Xue, L.-X., Chen, S., Xue, S.-X., Zhang, X., & Lian, Y. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.013 · Cited by 19 · see citing works
Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome
Hayashi, R., Okuno, Y., Mukai, K., Kitamura, T., Hayakawa, T., Onodera, T., Murata, M., Fukuhara, A., Imamura, R., Miyagawa, Y., et al. (2019) · Endocrinology · doi:10.1210/en.2018-01029 · Cited by 19 · see citing works
Shimizu, K., Ono, M., Imoto, A., Nagayama, H., Tetsumura, N., Terada, T., Tomita, K., & Nishinaka, T. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00984 · Cited by 19 · see citing works
Redox Biology in Adipose Tissue Physiology and Obesity
Yu, J., Qiu, J., Zhang, Z., Cui, X., Guo, W., Sheng, M., Gao, M., Wang, D., Xu, L., & Ma, X. (2023) · Advanced Biology · doi:10.1002/adbi.202200234 · Cited by 19 · see citing works
Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors
Rau, C., Wu, S., Lu, T., Wu, Y.-C., Wu, C., Chien, P., Kuo, P., Lin, C.-W., Tsai, C.-W., & Hsieh, C. (2018) · Nutrients · doi:10.3390/nu10101464 · Cited by 17 · see citing works
Wang, X., Yang, Y., Zhao, D., Zhang, S., Chen, Y., Chen, Y., Feng, K., Li, X., Han, J., Iwakiri, Y., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101561 · Cited by 17 · see citing works
Qu, J., Tian, L., Zhang, M., Sun, B., & Chen, L. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112320 · Cited by 16 · see citing works
Bone marrow fat: friend or foe in people with diabetes mellitus?
Santopaolo, M., Gu, Y., Spinetti, G., & Madeddu, P. (2020) · Clinical science · doi:10.1042/cs20200220 · Cited by 13 · see citing works
Deng, M., Zhang, S., Wu, S., Jiang, Q., Teng, W., Luo, T., Ouyang, Y., Liu, J., & Gu, B. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1390293 · Cited by 15 · see citing works
Glutamine deficiency induces lipolysis in adipocytes
Okuro, K., Fukuhara, A., Minemura, T., Hayakawa, T., Nishitani, S., Okuno, Y., Otsuki, M., & Shimomura, I. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.11.043 · Cited by 14 · see citing works
Zhou, Z., Zhang, H., Tao, Y., Zang, J., Zhao, J., Li, H., Wang, Y., Wang, T., Zhao, H., Wang, F., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102877 · Cited by 13 · see citing works
Neto, I. V. D. S., Prestes, J., Pereira, G. B., de Almeida, J. A., Ramos, G. V., Veiga-Souza, F. H., de Souza, P. E. N., Tibana, R. A., Franco, O. L., Durigan, J. L. Q., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120377 · Cited by 13 · see citing works
Adipose Tissue Expansion by Overfeeding Healthy Men Alters Iron Gene Expression
Segrestin, B., Moreno‐Navarrete, J. M., Seyssel, K., Alligier, M., Meugnier, E., Nazare, J., Vidal, H., Fernández‐Real, J. M., & Laville, M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01169 · Cited by 12 · see citing works
Mediators of Impaired Adipogenesis in Obesity-Associated Insulin Resistance and T2DM
Al‐Sulaiti, H., Dömling, A. S. S., & Elrayess, M. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88746 · Cited by 12 · see citing works
Elsworthy, R. J., & Aldred, S. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110838 · Cited by 11 · see citing works
Hashimoto, Y., Hamaguchi, M., Kaji, A., Sakai, R., Kitagawa, N., & Fukui, M. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001189 · Cited by 11 · see citing works
Laget, J., Djohan, Y. F., Jeanson, L., Muyor, K., Badia, É., Cristol, J., Coudray, C., Feillet‐Coudray, C., Vigor, C., Oger, C., et al. (2021) · Nutrients · doi:10.3390/nu13041134 · Cited by 9 · see citing works
Ovalle-Marin, A., Reyes‐Farias, M., Vásquez, K. Y., Parra-Ruiz, C., Vilma Quitral, R., Jiménez, P., Garcı́a, L., Ramirez, L. A., Quezada, J. U. C., González‐Muniesa, P., et al. (2020) · Journal of Berry Research · doi:10.3233/jbr-200576 · Cited by 10 · see citing works
Pruett, J. E., Romero, D. G., & Cardozo, L. L. Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.951099 · Cited by 10 · see citing works
Fernández, M. A. R., Vilca, C. M. C., Batista, L. O., Figueiredo, L. S., Ribeiro, R. A., do Carmo, M. D. G. T., & de Albuquerque, K. T. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520004055 · Cited by 10 · see citing works
Ding, Z., Chen, M., Tao, X., Liu, Y., He, J., Wang, T., & Li, X. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01181 · Cited by 10 · see citing works
Isesele, P., Enstad, S., Pham, T. H., Thomas, R., Wagner, C. L., Sen, S., & Cheema, S. K. (2022) · Biomedicines · doi:10.3390/biomedicines10051129 · Cited by 10 · see citing works
Poor Cognitive Agility Conservation in Obese Aging People
Pardo-Moreno, T., Mohamed-Mohamed, H., Rivas-Domínguez, A., García‐Morales, V., García‐Lara, R. A., Suleiman‐Martos, N., Bermúdez, B., & Ramos‐Rodríguez, J. J. (2023) · Biomedicines · doi:10.3390/biomedicines11010138 · Cited by 9 · see citing works
Qu, Y., Wang, Y., Wu, T., Liu, X., Wang, H., & Ma, D.-F. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01967-0 · Cited by 7 · see citing works
Development of novel human in vitro vascularized adipose tissue model with functional macrophages
Huttala, O., Sarkanen, J., Mannerström, M., Toimela, T., Heinonen, T., & Ylikomi, T. J. (2020) · Cytotechnology · doi:10.1007/s10616-020-00407-6 · Cited by 8 · see citing works
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2
Nunoue, T., Yamaguchi, S., Teshigawara, S., Katayama, A., Nakatsuka, A., Eguchi, J., Niki, T., & Wada, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-85080-1 · Cited by 8 · see citing works
Croft, A. J., Kelly, C., Chen, D., Haw, T. J., Sverdlov, A. L., & Ngo, D. T. M. (2023) · Antioxidants · doi:10.3390/antiox12051137 · Cited by 8 · see citing works
Anti-obesity effects by parasitic nematode (Trichinella spiralis) total lysates
Kang, S. A., & Yu, H. S. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1285584 · Cited by 8 · see citing works
Wang, C., Noble, P. B., Elliot, J., James, A. L., & Wang, K. C. W. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220011 · Cited by 8 · see citing works
Pu, L., Luo, Y., Wen, Z., Dai, Y., Zheng, C., Zhu, X., Qin, L., Zhang, C., Liang, H., Zhang, J., et al. (2022) · Animals · doi:10.3390/ani12243528 · Cited by 7 · see citing works
Azarova, I. E., Klyosova, E. Y., Коломоец, И. И., Азарова, В. А., Ivakin, V. E., Konoplya, A. I., & Polonikov, A. (2020) · Russian Journal of Genetics · doi:10.1134/s1022795420070017 · Cited by 7 · see citing works
The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism
Okuno, Y., Fukuhara, A., & Shimomura, I. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej24-0177 · Cited by 6 · see citing works
Huang, M., Zhou, J., Zhu, Y., Luo, K., Zheng, S., Tang, H., Wu, Y., Xuan, R., Huang, Y., Li, J., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141724 · Cited by 6 · see citing works
Liu, H.-Q., Huang, Y.-Q., Lu, S.-S., Yuan, D.-D., & Liu, J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032382 · Cited by 5 · see citing works
Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress
Choi, M. J., Jung, S.-B., Chang, J. Y., & Shong, M. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.956 · Cited by 5 · see citing works
Lactate dehydrogenase regulates basal glucose uptake in adipocytes
Minemura, T., Fukuhara, A., Otsuki, M., & Shimomura, I. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.113 · Cited by 5 · see citing works
Szablewski, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80248 · Cited by 5 · see citing works
Association between obesity indicators and retinopathy in US adults: NHANES 2005–2008
Wang, C.-X., Kuang, M., Hou, J., Lin, S.-Y., Liu, S., Bao, N., & Jiang, Z. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1598240 · Cited by 4 · see citing works
Corticosteroid insensitivity in obese asthma: potential mechanisms and therapeutic perspectives
To, M., & To, Y. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1719900 · Cited by 4 · see citing works
Hongqu Rice Wines Ameliorate High-Fat/High-Fructose Diet-Induced Metabolic Syndrome in Rats
Zhang, N., Kong, F., Jing, X., Zhou, J., Zhao, L., Soliman, M. M., Zhang, L., & Zhou, F. L. (2022) · Alcohol and Alcoholism · doi:10.1093/alcalc/agac033 · Cited by 4 · see citing works
Woeller, C. F., Lim, S., Roztocil, E., Yee, M., Beier, E. E., Puzas, J. E., & O’Reilly, M. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.005 · Cited by 3 · see citing works
Abuduaini, B., Jiyuan, Z., Rehati, A., Liang, Z., & Yunlin, S. (2024) · Inflammation · doi:10.1007/s10753-024-02017-2 · Cited by 3 · see citing works
Laget, J., Vigor, C., Nouvel, A., Rocher, A., Leroy, J., Jeanson, L., Réversat, G., Oger, C., Galano, J., Durand, T., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.013 · Cited by 3 · see citing works
Shim, W.-S., Lee, S., Azamov, B., Lee, C., Kang, Y. J., Lee, K. M., Hong, C., Kwon, S., Kim, K., Lee, D., et al. (2025) · Biochemical Journal · doi:10.1042/bcj20253035 · Cited by 2 · see citing works
MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes
Nishio, M., Yamaguchi, K., Otani, J., Yuguchi, K., Kohno, D., Sasaki, T., Kitamura, T., Shinohara, M., Soga, T., Kawamura, K., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424741122 · Cited by 3 · see citing works
- Authors
- Okuno, Y., Fukuhara, A., Hashimoto, E., Kobayashi, H., Kobayashi, S., Otsuki, M., & Shimomura, I.
- Affiliations
- The University of Osaka (JP)
- Corresponding author
- Fukuhara, Atsunori
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2018-04-04
- Volume
- 67
- Issue
- 6
- Pages
- 1113-1127
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2796021090
- Cited by
- 124
- References
- 56
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 11 · 2023: 14 · 2022: 18 · 2021: 24 · 2020: 18 · 2019: 15 · 2018: 4
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (KAKENHI grant #24591329)
- Japan Foundation for Applied Enzymology (grant)
- Japan Health Foundation
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- reactive oxygen species, adipose tissue expansion, de novo lipogenesis, SREBF1, LSD1, insulin resistance, ectopic fat deposition, diet-induced obesity, macrophage polarization, adipose tissue fibrosis
- MeSH terms
- Animals, Crosses, Genetic, Humans, Insulin Resistance, Macrophage Activation, Mice, Transgenic, Obesity, Specific Pathogen-Free Organisms, Biomarkers, Gene Expression Regulation, Enzymologic, Mice, Knockout, Oxidative Stress, RNA Interference, 3T3-L1 Cells, Lipogenesis, Adipogenesis, Mice, Rats, Sterol Regulatory Element Binding Protein 1, Adipose Tissue, White, Histone Demethylases, Diet, Western
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