Ishitani, Ryuichiro

Crystal structure of Cas9 in complex with guide RNA and target DNA

Nishimasu, H., Ran, F. A., Hsu, P. D., Konermann, S., Shehata, S. I., Dohmae, N., Ishitani, R., Zhang, F., & Nureki, O. (2014) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,306

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Nishimasu, H., Shi, X., Ishiguro, S., Gao, L., Hirano, S., Okazaki, S., Noda, T., Abudayyeh, O. O., Gootenberg, J. S., Mori, H., et al. (2018) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,100

Towards universal neural network potential for material discovery applicable to arbitrary combination of 45 elements

Takamoto, S., Shinagawa, C., Motoki, D., Nakago, K., Li, W., Kurata, I., Watanabe, T., Yayama, Y., Iriguchi, H., Asano, Y., et al. (2022) · Nature Communications

Machine Learning in Materials ScienceAdvanced Chemical Physics Studies

Cited by 446

Structure and function of a membrane component SecDF that enhances protein export

Tsukazaki, T., Mori, H., Echizen, Y., Ishitani, R., Fukai, S., Tanaka, T., Perederina, A., Vassylyev, D. G., Kohno, T., Maturana, A. D., et al. (2011) · Nature

Bacterial Genetics and BiotechnologyHeat shock proteins research

Cited by 219

Structural basis for the altered PAM specificities of engineered CRISPR-cas9

Hirano, S., Nishimasu, H., Ishitani, R., & Nureki, O. (2016) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 152

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

Taniguchi, R., Kato, H. E., Font, J., Deshpande, C. N., Wada, M., Ito, K., Ishitani, R., Jormakka, M., & Nureki, O. (2015) · Nature Communications

Iron Metabolism and DisordersProtein Structure and Dynamics

Cited by 120

Mg2+‐dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis

Hattori, M., Iwase, N., Furuya, N., Tanaka, Y., Tsukazaki, T., Ishitani, R., Maguire, M. E., Ito, K., Maturana, A., & Nureki, O. (2009) · The EMBO Journal

Ion channel regulation and functionMagnesium in Health and Disease

Cited by 109

Structural basis for the altered PAM recognition by engineered CRISPR-Cpf1

Nishimasu, H., Yamano, T., Gao, L., Zhang, F., Ishitani, R., & Nureki, O. (2017) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 102

Improving Stereochemical Limitations in Protein-Ligand Complex Structure Prediction

Ishitani, R., & Moriwaki, Y. (2025) · ACS Omega

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 19

Improving Stereochemical Limitations in Protein–Ligand Complex Structure Prediction

Ishitani, R., & Moriwaki, Y. (2025) · ACS Omega

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 19

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I., & Osawa, M. (2018) · eLife

Ion channel regulation and functionMagnesium in Health and Disease

Cited by 17

GenSPARC: Generalized Structure- and Property-Aware Representations of Language Models for Compound-Protein Interaction Prediction

Tomita, A., Zhang, Y., Takemoto, M., & Ishitani, R. (2025) · Communications Chemistry

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 1

Generalizable compound protein interaction prediction with a model incorporating protein structure aware and compound property aware language model representations

Zhang, Y., Ishitani, R., Takemoto, M., & Tomita, A. (2025) · Communications Chemistry

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 1

Multi-objective optimization for designing structurally similar proteins with dissimilar sequences

Akiba, R., Moriwaki, Y., Ishitani, R., & Yoshikawa, N. (2026) · Science and Technology of Advanced Materials: Methods

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 1

Multi-objective optimization for designing structurally similar proteins with diverse sequences

Akiba, R., Moriwaki, Y., Ishitani, R., & Yoshikawa, N. (2025) · Science and Technology of Advanced Materials Methods

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 1