Nave, Klaus-Armin

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

Trajkovic, K., Dhaunchak, A. S., Goncalves, J. T., Wenzel, D., Schneider, A., Bunt, G., Nave, K.-A., & Simons, M. (2006) · The Journal of Cell Biology

Cellular transport and secretionNeurogenesis and neuroplasticity mechanisms

Cited by 186

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes

Simons, M., Krämer, E.-M., Macchi, P., Rathke-Hartlieb, S., Trotter, J., Nave, K.-A., & Schulz, J. B. (2002) · The Journal of Cell Biology

Lysosomal Storage Disorders ResearchCellular transport and secretion

Cited by 168

Myelination and Oligodendrocyte Functions in Psychiatric Diseases

Nave, K.-A., & Ehrenreich, H. (2014) · JAMA Psychiatry

Neurogenesis and neuroplasticity mechanismsSchizophrenia research and treatment

Cited by 157

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

Supplie, L. M., Düking, T., Campbell, G., Diaz, F., Moraes, C. T., Götz, M., Hamprecht, B., Boretius, S., Mahad, D., & Nave, K.-A. (2017) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchMitochondrial Function and Pathology

Cited by 153

Monitoring ATP dynamics in electrically active white matter tracts

Trevisiol, A., Saab, A. S., Winkler, U., Marx, G., Imamura, H., Möbius, W., Kusch, K., Nave, K.-A., & Hirrlinger, J. (2017) · eLife

Mitochondrial Function and PathologyAdvanced Fluorescence Microscopy Techniques

Cited by 151

Cholesterol: A Novel Regulatory Role in Myelin Formation

Saher, G., Quintes, S., & Nave, K.-A. (2011) · The Neuroscientist

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 144

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., & Relvas, J. B. (2006) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 142

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Weil, M.-T., Möbius, W., Winkler, A., Ruhwedel, T., Wrzos, C., Romanelli, E., Bennett, J. L., Enz, L., Goebels, N., Nave, K.-A., et al. (2016) · Cell Reports

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 142

Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity

Wang, H., Astarita, G., Taussig, M. D., Bharadwaj, K. G., DiPatrizio, N. V., Nave, K.-A., Piomelli, D., Goldberg, I. J., & Eckel, R. H. (2011) · Cell Metabolism

Regulation of Appetite and ObesityLipid metabolism and disorders

Cited by 139

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Asadollahi, E., Trevisiol, A., Saab, A. S., Looser, Z. J., Dibaj, P., Ebrahimi, R., Kusch, K., Ruhwedel, T., Möbius, W., Jahn, O., et al. (2024) · Nature Neuroscience

Lipid metabolism and biosynthesisNeurogenesis and neuroplasticity mechanisms

Cited by 130

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 125

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

Saher, G., Rudolphi, F., Corthals, K., Ruhwedel, T., Schmidt, K.-F., Löwel, S., Dibaj, P., Barrette, B., Möbius, W., & Nave, K.-A. (2012) · Nature Medicine

Multiple Sclerosis Research StudiesLysosomal Storage Disorders Research

Cited by 123

Survival of adult neurons lacking cholesterol synthesis in vivo

Fünfschilling, U., Saher, G., Xiao, L., Möbius, W., & Nave, K.-A. (2007) · BMC Neuroscience

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 120

Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium

Nawaz, S., Kippert, A., Saab, A. S., Werner, H. B., Lang, T., Nave, K.-A., & Simons, M. (2009) · The Journal of Neuroscience

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 116

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Meschkat, M., Steyer, A. M., Weil, M.-T., Kusch, K., Jahn, O., Piepkorn, L., Agüi-Gonzalez, P., Phan, N. T. N., Ruhwedel, T., Sadowski, B., et al. (2022) · Nature Communications

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 112

Adapting brain metabolism to myelination and long‐range signal transduction

Hirrlinger, J., & Nave, K. (2014) · Glia

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 109

Microglia ablation alleviates myelin-associated catatonic signs in mice

Janova, H., Arinrad, S., Balmuth, E., Mitjans, M., Hertel, J., Habes, M., Bittner, R. A., Pan, H., Goebbels, S., Begemann, M., et al. (2017) · Journal of Clinical Investigation

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 107

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2024) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 104

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Schäffner, E., Bosch-Queralt, M., Edgar, J. M., Lehning, M., Strauß, J., Fleischer, N., Kungl, T., Wieghofer, P., Berghoff, S. A., Reinert, T., et al. (2023) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 101

Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7

Feldmann, A., Amphornrat, J., Schönherr, M., Winterstein, C., Möbius, W., Ruhwedel, T., Danglot, L., Nave, K.-A., Galli, T., Bruns, D., et al. (2011) · The Journal of Neuroscience

Cellular transport and secretionNeurogenesis and neuroplasticity mechanisms

Cited by 99

Global transcriptome analysis of genetically identified neurons in the adult cortex

Rossner, M. J., Hirrlinger, J., Wichert, S. P., Boehm, C., Newrzella, D., Hiemisch, H., Eisenhardt, G., Stuenkel, C., von Ahsen, O., & Nave, K.-A. (2006) · The Journal of Neuroscience

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 89

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis

Saito, K., Dubreuil, V., Arai, Y., Wilsch-Bräuninger, M., Schwudke, D., Saher, G., Miyata, T., Breier, G., Thiele, C., Shevchenko, A., et al. (2009) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 88

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

Erwig, M. S., Patzig, J., Steyer, A. M., Dibaj, P., Heilmann, M., Heilmann, I., Jung, R. B., Kusch, K., Möbius, W., Jahn, O., et al. (2019) · eLife

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 79

Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice

Cathomas, F., Azzinnari, D., Bergamini, G., Sigrist, H., Buerge, M., Hoop, V., Wicki, B., Goetze, L., Soares, S., Kukelova, D., et al. (2019) · Genes, Brain and Behavior

Stress Responses and CortisolNeurogenesis and neuroplasticity mechanisms

Cited by 78