Brown, Guy C.

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 6,226

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews

Physiological and biochemical adaptationsMitochondrial Function and Pathology

Cited by 2,021

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters

Nitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Cited by 1,055

Persistent inhibition of cell respiration by nitric oxide: Crucial role of S -nitrosylation of mitochondrial complex I and protective action of glutathione

Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 863

Microglial Phagocytosis of Live Neurons

Brown, G. C., & Neher, J. J. (2014) · Nature Reviews Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 853

Nitric oxide and mitochondrial respiration

Brown, G. C. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyNitric Oxide and Endothelin Effects

Cited by 702

Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity

Bal-Price, A., & Brown, G. C. (2001) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 686

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 638

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyNitric Oxide and Endothelin Effects

Cited by 602

The endotoxin hypothesis of neurodegeneration

Brown, G. C. (2019) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 457

Nitric oxide inhibition of mitochondrial respiration and its role in cell death

Brown, G. C., & Borutaite, V. (2002) · Free Radical Biology and Medicine

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 377

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

Neher, J. J., Neniskyte, U., Zhao, J.-W., Bal-Price, A., Tolkovsky, A. M., & Brown, G. C. (2011) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 373

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

Boza-Serrano, A., Ruiz, R., Sanchez-Varo, R., García-Revilla, J., Yang, Y., Jimenez-Ferrer, I., Paulus, A., Wennström, M., Vilalta, A., Allendorf, D., et al. (2019) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 357

Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols

Brown, G. C., & Borutaite, V. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyNitric Oxide and Endothelin Effects

Cited by 344

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

Clementi, E., Brown, G. C., Foxwell, N., & Moncada, S. (1999) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Cited by 296

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

Fricker, M., Neher, J. J., Zhao, J.-W., Théry, C., Tolkovsky, A. M., & Brown, G. C. (2012) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 218

Total cell protein concentration as an evolutionary constraint on the metabolic control distribution in cells

Brown, G. C. (1991) · Journal of Theoretical Biology

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 131

Cell death by phagocytosis

Brown, G. C. (2024) · Nature Reviews Immunology

Phagocytosis and Immune RegulationCell death mechanisms and regulation

Cited by 129

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

Nomura, K., Vilalta, A., Allendorf, D. H., Hornik, T. C., & Brown, G. C. (2017) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 111

TET2 Regulates the Neuroinflammatory Response in Microglia

Carrillo-Jimenez, A., Deniz, Ö., Niklison-Chirou, M. V., Ruiz, R., Bezerra-Salomão, K., Stratoulias, V., Amouroux, R., Yip, P. K., Vilalta, A., Cheray, M., et al. (2019) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 104

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

Fricker, M., Vilalta, A., Tolkovsky, A. M., & Brown, G. C. (2013) · Journal of Biological Chemistry

Neuroinflammation and Neurodegeneration MechanismsCell death mechanisms and regulation

Cited by 92

Why do protein kinase cascades have more than one level?

Brown, G. C., Hoek, J. B., & Kholodenko, B. N. (1997) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingGene Regulatory Network Analysis

Cited by 88

Highly purified lipoteichoic acid induced pro‐inflammatory signalling in primary culture of rat microglia through Toll‐like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide

Kinsner, A., Boveri, M., Hareng, L., Brown, G. C., Coecke, S., Hartung, T., & Bal‐Price, A. (2006) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 59