Cell death by phagocytosis

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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Role of CD47 as a Marker of Self on Red Blood Cells

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

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CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

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Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

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Programmed cell senescence during mammalian embryonic development

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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

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The multifaceted functions of neutrophils

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C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

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Neuronal Cell Death

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Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

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Phagocytosis checkpoints as new targets for cancer immunotherapy

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The clearance of dead cells by efferocytosis

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UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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Microglia Promote the Death of Developing Purkinje Cells

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Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

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A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

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CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

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A complement–microglial axis drives synapse loss during virus-induced memory impairment

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Phagocytosis: Our Current Understanding of a Universal Biological Process

Uribe-Querol, E., & Rosales, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01066 · Cited by 651 · see citing works

TAM receptors regulate multiple features of microglial physiology

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Phagocytosis and antigen presentation in dendritic cells

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Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

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Redox Reactions and Microbial Killing in the Neutrophil Phagosome

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Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

Zhao, L., Zabel, M. K., Wang, X., Ma, W., Shah, P., Fariss, R. N., Qian, H., Parkhurst, C. N., Gan, W., & Wong, W. T. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505298 · Cited by 451 · see citing works

How macrophages deal with death

Lemke, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0167-y · Cited by 437 · see citing works

Calreticulin and cancer

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Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

Neher, J. J., Neniskyte, U., Zhao, J.-W., Bal-Price, A., Tolkovsky, A. M., & Brown, G. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003600 · Cited by 373 · see citing works

Phagocytosis executes delayed neuronal death after focal brain ischemia

Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 350 · see citing works

Mechanism of removal of senescent cells by human macrophages in situ.

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Biochemical and functional characterization of the interaction between pentraxin 3 and C1q

Nauta, A. J., Bottazzi, B., Mantovani, A., Salvatori, G., Kishore, U., Schwaeble, W., Gingras, A. R., Tzima, S., Vivanco, F., Egido, J., et al. (2003) · European Journal of Immunology · doi:10.1002/immu.200310022 · Cited by 348 · see citing works

Phagocytosis promotes programmed cell death in C. elegans

Reddien, P. W., Cameron, S., & Horvitz, H. R. (2001) · Nature · doi:10.1038/35084096 · Cited by 348 · see citing works

CD47 functions as a molecular switch for erythrocyte phagocytosis

Burger, P., Hilarius-Stokman, P., de Korte, D., van den Berg, T. K., & van Bruggen, R. (2012) · Blood · doi:10.1182/blood-2011-10-386805 · Cited by 338 · see citing works

The origin of Metazoa: a unicellular perspective

Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332 · see citing works

Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans

Hoeppner, D. J., Hengartner, M. O., & Schnabel, R. (2001) · Nature · doi:10.1038/35084103 · Cited by 295 · see citing works

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

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Cannibalism of Live Lymphocytes by Human Metastatic but Not Primary Melanoma Cells

Lugini, L., Matarrese, P., Tinari, A., Lozupone, F., Federici, C., Iessi, E., Gentile, M., Luciani, F., Parmiani, G., Rivoltini, L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3204 · Cited by 289 · see citing works

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

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bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

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From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis

Klei, T. R. L., Meinderts, S. M., van den Berg, T. K., & van Bruggen, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00073 · Cited by 262 · see citing works

Programmed cell removal: a new obstacle in the road to developing cancer

Chao, M. P., Majeti, R., & Weissman, I. L. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3171 · Cited by 246 · see citing works

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

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Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

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Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

Neniškytė, U., Neher, J. J., & Brown, G. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267583 · Cited by 208 · see citing works

Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of Phosphatidylserine

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Constitutive exposure of phosphatidylserine on viable cells

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Regulated Externalization of Phosphatidylserine at the Cell Surface

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Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination

Nemes-Baran, A. D., White, D. R., & DeSilva, T. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108047 · Cited by 196 · see citing works

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Brelstaff, J., Tolkovsky, A. M., Ghetti, B., Goedert, M., & Spillantini, M. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.072 · Cited by 195 · see citing works

Sex differences in microglial phagocytosis in the neonatal hippocampus

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Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation

Khandelwal, S., van Rooijen, N., & Saxena, R. K. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01348.x · Cited by 185 · see citing works

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

Liu, G., Wang, J., Park, Y.-J., Tsuruta, Y., Lorne, E., Zhao, X., & Abraham, E. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4240 · Cited by 185 · see citing works

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens

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Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells

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Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa

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Programmed cell removal by calreticulin in tissue homeostasis and cancer

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Lipid peroxidation causes endosomal antigen release for cross-presentation

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Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo

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Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

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Scavenger receptors in host defense: from functional aspects to mode of action

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Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

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Massive oxidation of phospholipid membranes leads to pore creation and bilayer disintegration

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The Phagocytic Code Regulating Phagocytosis of Mammalian Cells

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Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool

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PAI-1 inhibits neutrophil efferocytosis

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Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia

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TREM2 triggers microglial density and age-related neuronal loss

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Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes

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Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke

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Microglia engulf viable newborn cells in the epileptic dentate gyrus

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Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

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TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells

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Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer

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NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages

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Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia

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Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

Yanuck, S. F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00712 · Cited by 80 · see citing works

Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis

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The origin of phagocytosis in Earth history

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Lactadherin/ MFG ‐E8 is essential for microglia‐mediated neuronal loss and phagoptosis induced by amyloid β

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Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death

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The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration

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Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary

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Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis

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Efferocytosis in Health and Disease

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New Ca2+ based anticancer nanomaterials trigger multiple cell death targeting Ca2+ homeostasis for cancer therapy

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TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration

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Phagocytosis‐Activating Nanocomplex Orchestrates Macrophage‐Mediated Cancer Immunotherapy

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Immunomodulatory effects of Sanghuangporus flavonoids: Key insights into enhancing immunity and restoring immune function

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The Dual Role of Macrophages in MIRI and MI by Immunity and Inflammation: Damage, Repair, Crosstalk, and Therapy

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Decoding of the Role of TREM2 in Neuropathic Pain: Molecular Pathway and Neuroinflammatory Mechanism

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Immune mechanisms targeting malaria transmission: opportunities for vaccine development

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Recent Research Advances on the Hippo‐Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture

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CD44-targeted nanoparticles for remodeling the tumor microenvironment in a 3D macrophage-embedded ovarian cancer model with stem cell-like features

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Protein Kinases in Phagocytosis: Promising Genetic Biomarkers for CancerPreprint

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RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC + Tumor‐Associated Macrophages

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Evaluation of the multivalent immune protective effects of the Vibrio fluvialis outer membrane protein VF17320, and its DNA and IgY antibody vaccines in fish

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Sialylation as a checkpoint for inflammatory and complement-related retinal diseases

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Distinct UPR and Autophagic Functions Define Cell-Specific Responses to Proteotoxic Stress in Microglial and Neuronal Cell Lines

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Structural characterization and immunomodulatory activity of polysaccharides from the flowers of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb

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GATA factor Serpent promotes phagocytosis in non-professional phagocytes during Drosophila oogenesis

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Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

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The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

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N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease

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The Perils and Promise of Cellular Cannibalism in Development, Homeostasis, and Disease

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Pulmonary macrophage-targeted RNAi and mRNA co-delivery via SORT lipid nanoparticles enhances immunotherapy in lung cancer

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Microglial low-affinity FcγR mediates the phagocytic elimination of dopaminergic neurons in Parkinson’s disease degeneration

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Role of PI3Kγ in the polarization, migration, and phagocytosis of microglia

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Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis

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Innate Immune Pathways Regulating Retinal Cell Development and Regeneration

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Targeting VCP enhances colorectal cancer therapy through STING stabilization

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The Effects of Flavored Vaped E-liquids on Cultured Human Macrophages Derived from the Central and Peripheral Nervous Systems

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Berberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway

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Engineered Strategies to Interfere with Macrophage Fate in Myocardial Infarction

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Vascular‐Associated Mononuclear Phagocytes: First‐Line Soldiers Ambushing Metastasis

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Microglial phagoptosis in development, health, and disease

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Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis

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Molecular PET imaging of tumor-associated macrophages in precision oncology

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Dual blockade of GSTK1 and CD47 improves macrophage-mediated phagocytosis on cancer cells

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Galectin 3: A new player in the pathogenesis of Parkinson’s disease

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Liver transcriptome profiling of the largemouth bass ( Micropterus salmoides ) suggests host immunoregulatory mechanism in response to Edwardsiella tarda infection

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A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction

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MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia

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IRE1α regulates macrophage phagocytosis in immune thrombocytopenia through NR1D1 mRNA decay and lysosomal biogenesis

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3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer

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Hyperactive Rac converts sublethal to lethal trogocytosis in vivo

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Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors.

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Pilot Study of the Total and Phosphorylated Tau Proteins in Early-Stage Multiple Sclerosis

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The battle within: cell death by phagocytosis in cancer

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Intercellular Molecular Transfer Mediated by Extracellular Vesicles in Cancer

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A bottom‐up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors

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Transport and immunomodulatory effect of Hericium erinaceus peptide LPGKVIAS

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Transcriptome landscape of the adrenal gland and superior cervical ganglion from hypertension-induced left ventricular hypertrophy rat model

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Inhibition of inner ear macrophage phagocytosis alleviates cisplatin-induced ototoxicity

Zhang, J., Zhang, W., Huang, X., Li, M., & Yang, H. (2025) · Communications Biology · doi:10.1038/s42003-025-08525-7 · Cited by 2 · see citing works

Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration after Axotomy

Pottorf, T. S., Lane, E. L., Haley-Johnson, Z., Ukmar, D. N., Amores-Sanchez, V., Correa-Torres, P. M., & Álvarez, F. J. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0112-26.2026 · Cited by 2 · see citing works

Magnetic-Responsive Semilifeform for Protecting Peritumoral T Lymphocytes and Precise Tumor Eradication

Yang, C. S., Wu, Q., Liu, J., Wang, X., Pang, B., & Tang, R. (2025) · ACS Nano · doi:10.1021/acsnano.5c12781 · Cited by 2 · see citing works

Role of myeloid cells in neural repair after brain tissue injury

Koyama, R., & Shichita, T. (2024) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12808 · Cited by 2 · see citing works

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosisPreprint

Chung, J., Vallurupalli, M., Noel, S., Schor, G., Liu, Y., Nobrega, C., Perera, J., Wrona, E., Hu, M., Lin, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.652090 · Cited by 2 · see citing works

Development of Engineered Microparticles for Investigating Enzymatic Degradation of Proteins and Peptides within Phagosomes

Fukuda, M., Lin, G. R., Liu, Y., Hammel, G., Kizer, A., Ayazi, M., Joshi, S., Liu, Y., Ren, Y., & Guan, J. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c22223 · Cited by 1 · see citing works

Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging

Xu, X., Lu, X., Chen, X., Yao, A., & Wei, L. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70098 · Cited by 1 · see citing works

Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke

Zhang, X., Xu, H., Ren, X.-W., Li, Q.-X., Hong, C., Chen, Y.-F., Yang, J., Ji, J., Guo, R., & Sun, X. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107020 · Cited by 2 · see citing works

Roles of the phagocytosis checkpoint in radiotherapy

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Comparative liver proteomic analysis of protein expression changes in an acute-on-chronic liver failure mouse model

Wang, K., Zou, Z., & Wei, D. (2025) · European Journal of Inflammation · doi:10.1177/1721727x251375816 · Cited by 1 · see citing works

Tumoural Hypoxic Extracellular Vesicles Foster a Protective Microenvironment in Triple‐Negative Breast Cancer

Pachane, B. C., Bottaro, P. H. T., Machado, A. M., de Castro, C. A., Guerra, G. G., Gozzer, L. T., Grigoli, M. M., Zutião, A. D., Fuzer, A. M., Cominetti, M. R., et al. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70075 · Cited by 1 · see citing works

Rosmarinic Acid as a Potential Therapeutic Agent against Neuroblastoma: Anticancer Activity and Molecular Docking Insights

Yumrutaş, P., Kahraman, D. T., & Yumrutaş, Ö. (2025) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206406705250911103628 · Cited by 1 · see citing works

Xenophagocytosis blockade enhances interspecies chimerism

Wang, S., Niizuma, K., Liu, D. D., Suchy, F. P., Chang, A. H., Tabatabaee, S., Sato, H., Yanagida, A., Masaki, H., Hidajat, N., et al. (2026) · Cell · doi:10.1016/j.cell.2026.05.016 · Cited by 1 · see citing works

Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification

Bandyadka, S., Tohline, L., Wandji, G.-V., Toledano, H., & McCall, K. (2025) · Frontiers in Cell Death · doi:10.3389/fceld.2025.1677498 · Cited by 1 · see citing works

Reassessing the tmRNA-SmpB complex as a virulence determinant

Nagarajan, T., & Kumaran, N. A. M. (2025) · Gene · doi:10.1016/j.gene.2025.149928 · Cited by 1 · see citing works

Microglial mechanisms of viable retinal ganglion cell elimination

López, N. N., Rodríguez, Y. L., & Vetter, M. L. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1719791 · Cited by 1 · see citing works

Metabolomic identification and analysis of potential biomarkers of febrile seizures

Tang, H., Yuan, G., Li, X., Pan, S., Liang, Y., Yang, Q., & Gao, X. (2026) · BMC Pediatrics · doi:10.1186/s12887-025-06497-5 · Cited by 1 · see citing works

Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation

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Phagocyte-inspired supramolecular self-assembly design of abiotic cell-mimics for pathogen recognition and eradication

Sahar, S., Ge, Y., Yang, S., Wang, Q., Zhang, M., Zhu, W., Zeb, A., Šutka, A., Sheng, G., Sheng, J., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.03.027 · Cited by 1 · see citing works

“AND” Logic-Gated Biomimetic Nanoparticles to Activate Macrophage Phagocytosis for Cancer Immunotherapy

Zhang, T., Luo, J.-Q., Liu, Y., Yu, H.-H., Zhang, X., Zhuang, Z.-H., Rao, L., & Du, J. (2026) · Nano Letters · doi:10.1021/acs.nanolett.5c05413 · Cited by 1 · see citing works

Cancer in transition: discovery of tumor-intrinsic transcriptional programs shaping the immune and microenvironmental landscape

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Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts

Wang, Z., Cheng, Q., Zhou, M., Feng, K., Chen, Q., Yuan, Y., Zhang, S., Kong, D., Wang, K., & Wang, J. (2026) · Nature Communications · doi:10.1038/s41467-026-71975-y · Cited by 1 · see citing works

Sulfated galactans from Gracilaria corticata reprogram metabolism, activate Immunity, promote regeneration, and exhibit anti-melanoma activity

Premarathna, A. D., Dziubińska‐Kühn, K., Sooäär, A., Pushpitha, N. P., Darko, C. N. S., Bai, R. G., Reile, I., & Tuvikene, R. (2026) · iScience · doi:10.1016/j.isci.2026.116692 · Cited by 1 · see citing works

Tumoral Hypoxic Extracellular Vesicles Foster a Protective Microenvironment in Triple-Negative Breast CancerPreprint

Pachane, B. C., Bottaro, P. H. T., Machado, A. M., de Castro, C. A., Guerra, G. G., Gozzer, L. T., Grigoli, M. M., Zutião, A. D., Fuzer, A. M., Cominetti, M. R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.01.621519

ATP11C as a key regulator of neuronal loss following intracerebral hemorrhage in mice

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Clinical and Laboratory Evaluation of the Condition of the Oral Cavity in Children with Acute Leukemia

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Cell Cannibalism: Why Do Our Cells Eat Each Other?

El-Sayed, A.-B. A. (2025) · International Journal of Immunology and Nursing Dynamics · doi:10.46610/ijind..2025.v01i01.001

Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology

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Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’

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Focusing on Phagocytes

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Recognizing death: the phagocytosis of apoptotic cells

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