Kurosaki, Tomohiro

Tyrosine kinases Lyn and Syk regulate B cell receptor‐coupled Ca2+ mobilization through distinct pathways.

Takata, M., Sabe, H., Hata, A., Inazu, T., Homma, Y., Nukada, T., Yamamura, H., & Kurosaki, T. (1994) · The EMBO Journal

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 650

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

Ishiai, M., Kurosaki, M., Pappu, R., Okawa, K., Ronko, I., Fu, C., Shibata, M., Iwamatsu, A., Chan, A. C., & Kurosaki, T. (1999) · Immunity

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 318

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., et al. (2012) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 263

BLNK

Kurosaki, T., & Tsukada, S. (2000) · Immunity

T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

Cited by 223

A distinct subpopulation of CD25 − T-follicular regulatory cells localizes in the germinal centers

Wing, J. B., Kitagawa, Y., Locci, M., Hume, H., Tay, C., Morita, T., Kidani, Y., Matsuda, K., Inoue, T., Kurosaki, T., et al. (2017) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 211

Regulation of B-cell signal transduction by adaptor proteins

Kurosaki, T. (2002) · Nature Reviews Immunology

T-cell and B-cell ImmunologyNF-κB Signaling Pathways

Cited by 209

Involvement of Guanosine Triphosphatases and Phospholipase C-γ2 in Extracellular Signal–regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor

Hashimoto, A., Okada, H., Jiang, A., Kurosaki, M., Greenberg, S., Clark, E. A., & Kurosaki, T. (1998) · The Journal of Experimental Medicine

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 199

Generation of memory B cells and their reactivation

Inoue, T., Moran, I., Shinnakasu, R., Phan, T. G., & Kurosaki, T. (2018) · Immunological Reviews

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 181

Phospholipase C-γ Is Required for Agonist-Induced Ca2+ Entry

Patterson, R. L., van Rossum, D. B., Ford, D. L., Hurt, K. J., Bae, S. S., Suh, P.-G., Kurosaki, T., Snyder, S. H., & Gill, D. L. (2002) · Cell

Protein Kinase Regulation and GTPase SignalingIon Channels and Receptors

Cited by 176

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

Weber, M., Treanor, B., Depoil, D., Shinohara, H., Harwood, N. E., Hikida, M., Kurosaki, T., & Batista, F. D. (2008) · The Journal of Experimental Medicine

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 170

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

Tsukumo, S.-I., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K., & Saito, T. (2013) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 168

Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+ Flux and Cytokine Production in Dendritic Cells

Xu, S., Huo, J., Lee, K.-G., Kurosaki, T., & Lam, K.-P. (2009) · Journal of Biological Chemistry

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 166

Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

Hashimoto, A., Takeda, K., Inaba, M., Sekimata, M., Kaisho, T., Ikehara, S., Homma, Y., Akira, S., & Kurosaki, T. (2000) · The Journal of Immunology

T-cell and B-cell ImmunologyNF-κB Signaling Pathways

Cited by 155

Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling

Watanabe, D., Hashimoto, S., Ishiai, M., Matsushita, M., Baba, Y., Kishimoto, T., Kurosaki, T., & Tsukada, S. (2001) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingT-cell and B-cell Immunology

Cited by 136

syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction

El-Hillal, O., Kurosaki, T., Yamamura, H., Kinet, J.-P., & Scharenberg, A. M. (1997) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCytokine Signaling Pathways and Interactions

Cited by 130

Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling

Oh-hora, M., Johmura, S., Hashimoto, A., Hikida, M., & Kurosaki, T. (2003) · The Journal of Experimental Medicine

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 113

The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., et al. (2014) · Nature Communications

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 98

Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation

Aiba, Y., Oh-hora, M., Kiyonaka, S., Kimura, Y., Hijikata, A., Mori, Y., & Kurosaki, T. (2004) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 79

PLC-γ2 is essential for formation and maintenance of memory B cells

Hikida, M., Casola, S., Takahashi, N., Kaji, T., Takemori, T., Rajewsky, K., & Kurosaki, T. (2009) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 73

Cutting Edge: Association of Phospholipase C-γ2 Src Homology 2 Domains with BLNK Is Critical for B Cell Antigen Receptor Signaling

Ishiai, M., Sugawara, H., Kurosaki, M., & Kurosaki, T. (1999) · The Journal of Immunology

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 71

Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

Aki, D., Minoda, Y., Yoshida, H., Watanabe, S., Yoshida, R., Takaesu, G., Chinen, T., Inaba, T., Hikida, M., Kurosaki, T., et al. (2008) · Genes to Cells

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 68

Coupling Between B Cell Receptor and Phospholipase C-γ2 Is Essential for Mature B Cell Development

Hikida, M., Johmura, S., Hashimoto, A., Takezaki, M., & Kurosaki, T. (2003) · The Journal of Experimental Medicine

T-cell and B-cell ImmunologyNF-κB Signaling Pathways

Cited by 62

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Kayama, H., Kohyama, M., Okuzaki, D., Motooka, D., Barman, S., Okumura, R., Muneta, M., Hoshino, K., Sasaki, I., Ise, W., et al. (2018) · Proceedings of the National Academy of Sciences

Inflammatory Bowel DiseaseImmune Response and Inflammation

Cited by 55

Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Zhang, Y., Garcia-Ibanez, L., Ulbricht, C., Lok, L. S. C., Pike, J. A., Mueller-Winkler, J., Dennison, T. W., Ferdinand, J. R., Burnett, C. J. M., Yam-Puc, J. C., et al. (2022) · Nature Communications

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 47