Vermeulen, Louis

The consensus molecular subtypes of colorectal cancer

Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 5,170

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010) · Nature Cell Biology

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 1,804

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

De Sousa E Melo, F., Wang, X., Jansen, M., Fessler, E., Trinh, A., de Rooij, L. P. M. H., de Jong, J. H., de Boer, O. J., van Leersum, R., Bijlsma, M. F., et al. (2013) · Nature Medicine

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

Cited by 771

Intestinal label-retaining cells are secretory precursors expressing Lgr5

Buczacki, S. J. A., Zecchini, H. I., Nicholson, A. M., Russell, R., Vermeulen, L., Kemp, R., & Winton, D. J. (2013) · Nature

Digestive system and related healthCancer Cells and Metastasis

Cited by 761

From tumour heterogeneity to advances in precision treatment of colorectal cancer

Punt, C. J. A., Koopman, M., & Vermeulen, L. (2017) · Nature Reviews Clinical Oncology

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 654

Cancer stem cell niche: the place to be

Borovski, T., De Sousa E Melo, F., Vermeulen, L., & Medema, J. P. (2011) · Cancer Research

Cancer Cells and MetastasisMesenchymal stem cell research

Cited by 518

Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: A retrospective, pooled biomarker study

Domingo, E., Freeman-Mills, L., Rayner, E., Glaire, M., Briggs, S., Vermeulen, L., Fessler, E., Medema, J. P., Boot, A., Morreau, H., et al. (2016) · The Lancet Gastroenterology & Hepatology

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

Cited by 308

DeepCC: a novel deep learning-based framework for cancer molecular subtype classification

Gao, F., Wang, W., Tan, M., Zhu, L., Zhang, Y., Fessler, E., Vermeulen, L., & Wang, X. (2019) · Oncogenesis

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 226

Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas

Kozar, S., Morrissey, E., Nicholson, A. M., van der Heijden, M., Zecchini, H. I., Kemp, R., Tavaré, S., Vermeulen, L., & Winton, D. J. (2013) · Cell Stem Cell

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 214

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., Warmerdam, D. O., Kakkar, V., Moreno, L. F., Vieira Braga, F. A., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 211

Clinical value of consensus molecular subtypes in colorectal cancer: a systematic review and meta-analysis

ten Hoorn, S., de Back, T. R., Sommeijer, D. W., & Vermeulen, L. (2022) · JNCI: Journal of the National Cancer Institute

Colorectal Cancer Treatments and StudiesColorectal Cancer Surgical Treatments

Cited by 203

Practical and robust identification of molecular subtypes in colorectal cancer by immunohistochemistry

Trinh, A., Trumpi, K., De Sousa E Melo, F., Wang, X., de Jong, J. H., Fessler, E., Kuppen, P. J. K., Reimers, M. S., Swets, M., Koopman, M., et al. (2017) · Clinical Cancer Research

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 180

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., De Sousa E Melo, F., Prasetyanti, P. R., IJspeert, J. E., Franitza, M., et al. (2016) · EMBO Molecular Medicine

TGF-β signaling in diseasesColorectal Cancer Treatments and Studies

Cited by 159

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Lenos, K. J., Bach, S., Ferreira Moreno, L., ten Hoorn, S., Sluiter, N. R., Bootsma, S., Vieira Braga, F. A., Nijman, L. E., van den Bosch, T., Miedema, D. M., et al. (2022) · Nature Communications

Intraperitoneal and Appendiceal MalignanciesColorectal Cancer Treatments and Studies

Cited by 125

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

Vellinga, T. T., den Uil, S., Rinkes, I. H. B., Marvin, D., Ponsioen, B., Alvarez-Varela, A., Fatrai, S., Scheele, C., Zwijnenburg, D. A., Snippert, H., et al. (2016) · Oncogene

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 115

Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data

Trinh, A., Lädrach, C., Dawson, H. E., ten Hoorn, S., Kuppen, P. J. K., Reimers, M. S., Koopman, M., Punt, C. J. A., Lugli, A., Vermeulen, L., et al. (2018) · British Journal of Cancer

Colorectal Cancer Treatments and StudiesCancer Cells and Metastasis

Cited by 83

Neoadjuvant chemotherapy affects molecular classification of colorectal tumors

Trumpi, K., Ubink, I., Trinh, A., Djafarihamedani, M., Jongen, J. M., Govaert, K. M., Elias, S. G., van Hooff, S. R., Medema, J. P., Lacle, M. M., et al. (2017) · Oncogenesis

Colorectal Cancer Treatments and StudiesCancer Cells and Metastasis

Cited by 46

AKT3 expression in mesenchymal colorectal cancer cells drives growth and is associated with epithelial-mesenchymal transition

Buikhuisen, J. Y., Gomez Barila, P. M., Torang, A., Dekker, D., de Jong, J. H., Cameron, K., Vitale, S., Stassi, G., van Hooff, S. R., Castro, M. A. A., et al. (2021) · Cancers

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 33

Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status: a multicenter case-cohort study

Haasnoot, K. J. C., Backes, Y., Moons, L. M. G., Kranenburg, O., Trinh, A., Vermeulen, L., Noë, M., Tuynman, J. B., van Lent, A. U. G., van Ginneken, R., et al. (2020) · Modern Pathology

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

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Interconnectivity between molecular subtypes and tumor stage in colorectal cancer

Coebergh van den Braak, R. R. J., ten Hoorn, S., Sieuwerts, A. M., Tuynman, J. B., Smid, M., Wilting, S. M., Martens, J. W. M., Punt, C. J. A., Foekens, J. A., Medema, J. P., et al. (2020) · BMC Cancer

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

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