Cancer stem cell niche: the place to be
Open accessAbstract
Tumors are being increasingly perceived as abnormal organs that, in many respects, recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea is the observation that only a small fraction of tumor cells is capable of initiating a new tumor. Because of the features that these cells share with somatic stem cells, they have been termed cancer stem cells (CSC). Normal stem cells reside in a “stem cell niche” that maintains them in a stem-like state. Recent data suggest that CSCs also rely on a similar niche, dubbed the “CSC niche,” which controls their self-renewal and differentiation. Moreover, CSCs can be generated by the microenvironment through induction of CSC features in more differentiated tumor cells. In addition to a role in CSC maintenance, the microenvironment is hypothesized to be involved in metastasis by induction of the epithelial-mesenchymal transition, leading to dissemination and invasion of tumor cells. The localization of secondary tumors also seems to be orchestrated by the microenvironment, which is suggested to form a premetastatic niche. Thus, the microenvironment seems to be of crucial importance for primary tumor growth as well as metastasis formation. Combined with its role in the protection of CSCs against genotoxic insults, these data strongly put forward the niche as an important target for novel therapies. Cancer Res; 71(3); 634–9. ©2011 AACR.
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This could lead to promotion of a pro-resting cancer stem cell niche for the most therapy-resistant stem-like cells, or to recruitment and promotion of tumorigenesis for more active progenitor cells.
“This may result into promotion of a pro-resting CSC niche [152, 153] for the most therapy-resistant stem-like cells, or recruitment and promotion of tumorigenesis for more active progenitor cells.”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [152]
The Introduction says the CSC niche shelters cancer stem cells from genotoxic insults and contributes to their therapy resistance. It does not describe the niche as promoting a resting or quiescent state. The citation is attached to the niche claim, so the subsequent alternative about active progenitor cells is not the basis of this verdict. (LLM, conf=0.84)
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“This may result into promotion of a pro-resting CSC niche [152, 153] for the most therapy-resistant stem-like cells, or recruitment and promotion of tumorigenesis for more active progenitor cells.”
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- Authors
- Borovski, T., De Sousa E Melo, F., Vermeulen, L., & Medema, J. P.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Authors' Affiliations: Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands
- Corresponding author
- Medema, Jan Paul
- Venue
- Cancer Research
- Published
- 2011-02-01
- Volume
- 71
- Issue
- 3
- Pages
- 634-639
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2146267383
- Cited by
- 518
- References
- 49
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 24 · 2023: 24 · 2022: 18 · 2021: 30 · 2020: 39 · 2019: 39 · 2018: 30 · 2017: 51 · 2016: 45 · 2015: 46 · 2014: 51 · 2013: 49 · 2012: 41
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- cancer stem cells, tumor microenvironment, stem cell niche, self-renewal, tumor differentiation, metastasis, epithelial-mesenchymal transition, pre-metastatic niche, tumor initiation
- MeSH terms
- Animals, Humans, Neoplasms, Neoplastic Stem Cells
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