Gorospe, Myriam

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science

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Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

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Circular RNAs in diseasesRNA Research and Splicing

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Identification of a target RNA motif for RNA-binding protein HuR

de Silanes, I. L., Zhan, M., Lal, A., Yang, X., & Gorospe, M. (2004) · Proceedings of the National Academy of Sciences

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Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Lal, A., Mazan‐Mamczarz, K., Kawai, T., Yang, X., Martindale, J. L., & Gorospe, M. (2004) · The EMBO Journal

RNA Research and SplicingRNA regulation and disease

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AGEMAP: A Gene Expression Database for Aging in Mice

Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., et al. (2007) · PLoS Genetics

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Overexpression of the Cytokine BAFF and Autoimmunity Risk

Steri, M., Orrù, V., Idda, M. L., Pitzalis, M., Pala, M., Zara, I., Sidore, C., Faà, V., Floris, M., Deiana, M., et al. (2017) · New England Journal of Medicine

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Transcriptome signature of cellular senescence

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microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age

Noren Hooten, N., Abdelmohsen, K., Gorospe, M., Ejiogu, N., Zonderman, A. B., & Evans, M. K. (2010) · PLoS ONE

MicroRNA in disease regulationGenetics, Aging, and Longevity in Model Organisms

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Identification of senescent cell surface targetable protein DPP4

Kim, K. M., Noh, J. H., Bodogai, M., Martindale, J. L., Yang, X., Indig, F. E., Basu, S. K., Ohnuma, K., Morimoto, C., Johnson, P. F., et al. (2017) · Genes & Development

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p16INK4a Translation Suppressed by miR-24

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Evidence for miR‐181 involvement in neuroinflammatory responses of astrocytes

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Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function

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Nuclear morphology is a deep learning biomarker of cellular senescence

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miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

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Analysis of Turnover and Translation Regulatory RNA-Binding Protein Expression through Binding to Cognate mRNAs

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Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence

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Survey of senescent cell markers with age in human tissues

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Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability

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MicroRNA 33 Regulates Glucose Metabolism

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Proteomics in aging research: A roadmap to clinical, translational research

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miR-375 Inhibits Differentiation of Neurites by Lowering HuD Levels

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Skeletal muscle transcriptome in healthy aging

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