Skeletal muscle transcriptome in healthy aging
Open accessAbstract
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22-83 years old) of the GESTALT study of the National Institute on Aging-NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age.
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In muscle biopsies from 53 healthy individuals (22-83 years old), CDKN2B mRNA was the top age-related transcript.
“another study using RNA sequencing analysis from muscle biopsies obtained from 53 healthy individuals (22–83 years old) found that with aging the cyclin-dependent kinase inhibitor 2B (CDKN2B) mRNA, which encodes a protein implicated in cellular senescence, was the top age-related transcript”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Tumasian et al., 2021
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- Authors
- Tumasian, R. A., Harish, A., Kundu, G., Yang, J.-H., Ubaida-Mohien, C., Gonzalez-Freire, M., Kaileh, M., Zukley, L. M., Chia, C. W., Lyashkov, A., Wood, W. H., Piao, Y., Coletta, C., Ding, J., Gorospe, M., Sen, R., De, S., & Ferrucci, L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ferrucci, Luigi
- ORCID
- Venue
- Nature Communications
- Published
- 2021-04-01
- Volume
- 12
- Issue
- 1
- Pages
- 2014-2014
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8016876
- OpenAlex
- W3142606313
- Cited by
- 126
- References
- 107
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 26 · 2023: 22 · 2022: 23 · 2021: 5
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (Z01-AG000996)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- skeletal muscle, healthy aging, transcriptome, gene expression, age-related changes, cellular senescence, insulin signaling, myogenesis, mRNA isoforms, oxidative phosphorylation, adipogenesis, muscle damage, muscle homeostasis, non-coding RNA
- MeSH terms
- Healthy Aging, Adult, Aged, Aged, 80 and over, Female, Homeostasis, Humans, Male, Middle Aged, Muscular Diseases, RNA, Messenger, Muscle, Skeletal, Gene Expression Profiling, RNA, Untranslated, Young Adult, RNA Isoforms, Transcriptome
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