MicroRNA 33 Regulates Glucose Metabolism

Ramírez, Cristina M.; Goedeke, Leigh; Rotllan, Noemi; Yoon, Je-Hyun; Cirera-Salinas, Daniel; Mattison, Julie A.; Suárez, Yajaira; de Cabo, Rafael; Gorospe, Myriam; Fernández-Hernando, Carlos

doi:10.1128/mcb.00016-13

Cited by 154MicroRNA in disease regulationMetabolism, Diabetes, and CancerPancreatic function and diabetes

MicroRNA 33 Regulates Glucose Metabolism

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Ramírez, Cristina M., Goedeke, Leigh, Rotllan, Noemi, Yoon, Je-Hyun, Cirera-Salinas, Daniel, Mattison, Julie A., Suárez, Yajaira, de Cabo, Rafael +2 more·2013·Molecular and Cellular Biology

DOI 10.1128/mcb.00016-13PMC PMC3719675

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Abstract

Metabolic diseases are characterized by the failure of regulatory genes or proteins to effectively orchestrate specific pathways involved in the control of many biological processes. In addition to the classical regulators, recent discoveries have shown the remarkable role of small noncoding RNAs (microRNAs [miRNAs]) in the posttranscriptional regulation of gene expression. In this regard, we have recently demonstrated that miR-33a and miR33b, intronic miRNAs located within the sterol regulatory element-binding protein (SREBP) genes, regulate lipid metabolism in concert with their host genes. Here, we show that miR-33b also cooperates with SREBP1 in regulating glucose metabolism by targeting phosphoenolpyruvate carboxykinase (PCK1) and glucose-6-phosphatase (G6PC), key regulatory enzymes of hepatic gluconeogenesis. Overexpression of miR-33b in human hepatic cells inhibits PCK1 and G6PC expression, leading to a significant reduction of glucose production. Importantly, hepatic SREBP1c/miR-33b levels correlate inversely with the expression of PCK1 and G6PC upon glucose infusion in rhesus monkeys. Taken together, these results suggest that miR-33b works in concert with its host gene to ensure a fine-tuned regulation of lipid and glucose homeostasis, highlighting the clinical potential of miR-33a/b as novel therapeutic targets for a range of metabolic diseases.

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SRC1 was up-regulated in miR-33b KI mice, opposite to the results of a previous report.
“SRC1 was up-regulated in miR-33bKI mice and it was opposite to the results of previous report14.”
From MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo (2014) · cites this paper as [14]

MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works
Untitled work
(2008) · doi:10.1038/nrg2290 · Cited by 5,199 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102 · see citing works
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821 · see citing works
Self-citation
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487 · see citing works
Self-citation
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440 · see citing works
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science · doi:10.1126/science.1189862 · Cited by 1,260 · see citing works
Self-citation
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science · doi:10.1126/science.1215135 · Cited by 1,199 · see citing works
Pervasive roles of microRNAs in cardiovascular biology
Small, E. M., & Olson, E. N. (2011) · Nature · doi:10.1038/nature09783 · Cited by 1,180 · see citing works
MicroRNAs 103 and 107 regulate insulin sensitivity
Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M., Heim, M. H., & Stoffel, M. (2011) · Nature · doi:10.1038/nature10112 · Cited by 1,000 · see citing works
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science · doi:10.1126/science.1189123 · Cited by 957 · see citing works
The Lin28/let-7 axis regulates glucose metabolism
Zhu, H., Shyh-Chang, N., Segrè, A., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J., Kharas, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.033 · Cited by 907 · see citing works
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis.
Pilkis, S. J., & Granner, D. K. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.004321 · Cited by 865 · see citing works
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y. K., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00010-9 · Cited by 847 · see citing works
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
Shimomura, I., Bashmakov, Y. K., Ikemoto, S., Horton, J. D., Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13656 · Cited by 779 · see citing works
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
Foretz, M., Guichard, C., Ferré, P., & Foufelle, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12737 · Cited by 748 · see citing works
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E., Goldstein, J. L., & Shimano, H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2961 · Cited by 703 · see citing works
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Dávalos, A., Goedeke, L., Smibert, P., Ramírez, C. M., Warrier, N. P., Andreo, U., Cirera-Salinas, D., Rayner, K., Suresh, U., Pastor-Pareja, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102281108 · Cited by 670 · cited 1× · see citing works
“It is well established that agonists of LXR, such as oxysterols or insulin, lead to the hepatic induction of SREBP1c and more recently miR-33b (28).”
BackgroundSelf-citation
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
Nakae, J., Kitamura, T., Silver, D. L., & Accili, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12876 · Cited by 652 · see citing works
Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver
Matsumoto, M., Pocai, A., Rossetti, L., DePinho, R. A., & Accili, D. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.006 · Cited by 616 · see citing works
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
Nakae, J., Biggs, W., Kitamura, T., Cavenee, W. K., Wright, C. V. E., Arden, K. C., & Accili, D. (2002) · Nature Genetics · doi:10.1038/ng890 · Cited by 616 · see citing works
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730870100 · Cited by 564 · see citing works
Self-citation
miR-33 links SREBP-2 induction to repression of sterol transporters
Marquart, T. J., Allen, R. M., Ory, D. S., & Baldán, Á. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005191107 · Cited by 562 · see citing works
ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose
Foretz, M., Pacot, C., Dugail, I., Lemarchand, P., Guichard, C., Lièpvre, X. L., Lubrano-Berthelier, C., Spiegelman, B. M., Kim, J. B., Ferré, P., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3760 · Cited by 548 · see citing works
Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action
Osborne, T. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000017200 · Cited by 521 · see citing works
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
Laffitte, B. A., Chao, L. C., Li, J., Walczak, R., Hummasti, S., Joseph, S. B., Castrillo, A., Wilpitz, D. C., Mangelsdorf, D. J., Collins, J. L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830671100 · Cited by 503 · see citing works
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
Li, X., Monks, B., Ge, Q., & Birnbaum, M. J. (2007) · Nature · doi:10.1038/nature05861 · Cited by 487 · see citing works
Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs
Frost, R. J., & Olson, E. N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118922109 · Cited by 448 · see citing works
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
Dentin, R., Liu, Y., Koo, S., Hedrick, S. A., Vargas, T., Heredia, J., Yates, J. R., & Montminy, M. (2007) · Nature · doi:10.1038/nature06128 · Cited by 400 · see citing works
Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works
Mutations in the Glucose-6-Phosphatase Gene that Cause Glycogen Storage Disease Type 1a
Lei, K.-J., Shelly, L. L., Pan, C., Sidbury, J. B., & CHOU, J. Y. (1993) · Science · doi:10.1126/science.8211187 · Cited by 377 · see citing works
Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR
Schmoll, D., Walker, K. S., Alessi, D. R., Grempler, R., Burchell, A., Guo, S., Walther, R., & Unterman, T. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003616200 · Cited by 349 · see citing works
Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin
Hall, R. K., Yamasaki, T., Kučera, T., Waltner-Law, M. E., O’Brien, R. M., & Granner, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004898200 · Cited by 283 · see citing works
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
Owen, J., Zhang, Y., Bae, S., Farooqi, M., Liang, G., Hammer, R., Goldstein, J., & Brown, M. S. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1213343109 · Cited by 276 · see citing works
Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
Blandino, G., Valerio, M., Cioce, M., Mori, F., Casadei, L., Pulito, C., Sacconi, A., Biagioni, F., Cortese, G., Galanti, S., et al. (2012) · Nature Communications · doi:10.1038/ncomms1859 · Cited by 240 · see citing works
Inactivation of the Glucose 6-Phosphate Transporter Causes Glycogen Storage Disease Type 1b
Hiraiwa, H., Pan, C., Lin, B., MOSES, S. W., & CHOU, J. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5532 · Cited by 165 · see citing works
Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease
Chopra, A. R., Louet, J., Saha, P., An, J., DeMayo, F. J., Xu, J., York, B., Karpen, S. J., Finegold, M. J., Moore, D. D., et al. (2008) · Science · doi:10.1126/science.1164847 · Cited by 161 · see citing works
SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes
Yamamoto, T., Shimano, H., Nakagawa, Y., Ide, T., Yahagi, N., Matsuzaka, T., Nakakuki, M., Takahashi, A., Suzuki, H., Sone, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310333200 · Cited by 143 · see citing works
Cdc2-like Kinase 2 Is an Insulin-Regulated Suppressor of Hepatic Gluconeogenesis
Rodgers, J. T., Haas, W., Gygi, S. P., & Puigserver, P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.006 · Cited by 132 · see citing works
The Coactivator SRC-1 Is an Essential Coordinator of Hepatic Glucose Production
Louet, J., Chopra, A. R., Sagen, J. V., An, J., York, B., Tannour‐Louet, M., Saha, P., Stevens, R. D., Wenner, B. R., Ilkayeva, O., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.009 · Cited by 69 · see citing works
The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism
Jeong, J., Kwak, I., Lee, K. Y., White, L. D., Wang, X., Brunicardi, F. C., O’Malley, B. W., & DeMayo, F. J. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0407 · Cited by 66 · see citing works

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Skuratovskaia, D., Vulf, M., Komar, A., Кириенкова, Е. В., & Litvinova, L. S. (2019) · Biomolecules · doi:10.3390/biom9060226 · Cited by 59 · see citing works
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Price, N., Holtrup, B., Kwei, S. L., Wabitsch, M., Rodeheffer, M. S., Bianchini, L., Suárez, Y., & Fernández-Hernando, C. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00745-15 · Cited by 54 · see citing works
Self-citation
microRNAs and HDL life cycle
Canfrán‐Duque, A., Ramírez, C. M., Goedeke, L., Lin, C., & Fernandez-Hernando, C. F. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu140 · Cited by 58 · see citing works
Self-citation
Evidence that microRNAs are part of the molecular toolkit regulating adult reproductive diapause in the mosquito, Culex pipiens
Meuti, M. E., Bautista-Jimenez, R., & Reynolds, J. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203015 · Cited by 55 · see citing works
Relevance of microRNA in metabolic diseases
Price, N., Ramírez, C., & Fernández-Hernando, C. (2014) · Critical reviews in clinical laboratory sciences · doi:10.3109/10408363.2014.937522 · Cited by 52 · see citing works
Self-citation
Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep
Lie, S., Morrison, J. L., Williams-Wyss, O., Suter, C. M., Humphreys, D. T., Ozanne, S. E., Zhang, S., MacLaughlin, S. M., Kleemann, D. O., Walker, S. K., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2013 · Cited by 55 · see citing works
RNA sequencing of db/db mice liver identifies lncRNA H19 as a key regulator of gluconeogenesis and hepatic glucose output
Goyal, N., Sivadas, A., Vellarikkal, S. K., Jayarajan, R., Verma, A., Sivasubbu, S., Scaria, V., & Datta, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-08281-7 · Cited by 56 · see citing works
Perspective: Milk microRNAs as Important Players in Infant Physiology and Development
Leroux, C., Chervet, M., & German, J. B. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab059 · Cited by 55 · see citing works
Distinct microRNA and mRNA responses elicited by ecdysone, diapause hormone and a diapause hormone analog at diapause termination in pupae of the corn earworm, Helicoverpa zea
Reynolds, J. A., Nachman, R. J., & Denlinger, D. L. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.09.013 · Cited by 52 · see citing works
The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells
Shi, H., Fang, R., Li, Y., Li, L., Zhang, W., Wang, H., Chen, F., Zhang, S., Zhang, X., & Ye, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.025 · Cited by 52 · see citing works
miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques
Afonso, M. S., Sharma, M., Schlegel, M., van Solingen, C., Koelwyn, G. J., Shanley, L. C., Beckett, L., Peled, D., Rahman, K., Giannarelli, C., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.317914 · Cited by 53 · see citing works
MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment
Novák, J., Vašků, J. B., Kára, T., & Novák, M. (2014) · Mediators of Inflammation · doi:10.1155/2014/275867 · Cited by 52 · see citing works
MicroRNA-33a-3p suppresses cell migration and invasion by directly targeting PBX3 in human hepatocellular carcinoma
Han, S., Han, H., Tian, X., Sun, H., Xue, D., Zhao, C., Jiang, S., He, X., Zheng, W., Wang, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9886 · Cited by 50 · see citing works
MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo
Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Nakazeki, F., Ide, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep05312 · Cited by 49 · see citing works
Insight into miRNAs related with glucometabolic disorder
Zhang, B., Shen, C., Zhu, B.-W., An, H., Zheng, B. J., Xu, S., Sun, J., Sun, P.-C., Zhang, W., Wang, J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.123 · Cited by 47 · see citing works
Role of microRNAs (miRNAs) in the pathophysiology of diabetes mellitus
Tiwari, J., Gupta, G., Pinto, T. D. J. A., Sharma, R., Pabreja, K., Matta, Y., Arora, N., Mishra, A., Sharma, R. K., & Dua, K. (2018) · Panminerva Medica · doi:10.23736/s0031-0808.17.03382-1 · Cited by 45 · see citing works
Nanomedicine Meets microRNA
Gadde, S., & Rayner, K. J. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307481 · Cited by 43 · see citing works
Non-alcoholic fatty liver disease and microRNAs expression, how it affects the development and progression of the disease
López-Sánchez, G. N., Domínguez‐Pérez, M., Uribe, M., Chávez-Tapia, N. C., & Nuño‐Lámbarri, N. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.04.012 · Cited by 43 · see citing works
MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking
Peng, H., Hsiao, J., Chou, S.-T., Hsu, Y.-M., Wu, G.-H., Shieh, Y., & Shiah, S. (2020) · Neoplasia · doi:10.1016/j.neo.2020.08.005 · Cited by 43 · see citing works
MicroRNA regulation of cholesterol metabolism
Citrin, K. M., Fernandez-Hernando, C. F., & Suárez, Y. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14566 · Cited by 44 · see citing works
Self-citation
Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5′-Monophosphate (AMP)-activated Protein Kinase α1
Meng, X., Guo, J., Fang, W., Dou, L., Li, M., Huang, X., Zhou, S., Man, Y., Tang, W., Yu, L., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.713768 · Cited by 42 · see citing works
Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming
Yang, D., Sun, L., Li, Z., & Gao, P. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-1498-7_7 · Cited by 42 · see citing works
MicroRNA regulation and analytical methods in cancer cell metabolism
Zhang, L.-F., Jiang, S., & Liu, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2508-y · Cited by 40 · see citing works
Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention
Ortega, R., Liu, B., & Persaud, S. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310777 · Cited by 41 · see citing works
Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?
Beck, R., Stýblo, M., & Sethupathy, P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0845-8 · Cited by 39 · see citing works
Downregulation of miR‐33b promotes non‐small cell lung cancer cell growth through reprogramming glucose metabolism miR‐33b regulates non‐small cell lung cancer cell growth
Zhai, S., Zhao, L., Lin, T. C., & Wang, W. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27961 · Cited by 39 · see citing works
Overexpression of miR‐329‐3p sensitizes osteosarcoma cells to cisplatin through suppression of glucose metabolism by targeting LDHA
Li, G., Li, Y., & Wang, D. (2020) · Cell Biology International · doi:10.1002/cbin.11476 · Cited by 39 · see citing works
miRNAs in Heart Development and Disease
Lozano-Velasco, E., Inácio, J., Sousa, I., Guimarães, A. R., Franco, D., Moura, G., & Belo, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031673 · Cited by 36 · see citing works
Control of very low-density lipoprotein secretion by N-ethylmaleimide-sensitive factor and miR-33
Allen, R. M., Marquart, T. J., Jesse, J. J., & Baldán, Á. (2014) · Circulation Research · doi:10.1161/circresaha.115.303100 · Cited by 38 · see citing works
Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins
Chen, W.-M., Sheu, W., Tseng, P.-C., Lee, T.-S., Lee, W.-J., Chang, P.-J., & Chiang, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154672 · Cited by 34 · see citing works
Downregulation of microRNA-33a promotes cyclin-dependent kinase 6, cyclin D1 and PIM1 expression and gastric cancer cell proliferation
Wang, Y., Zhou, X., Shan, B., Han, J., Wang, F., Fan, X., Lv, Y., Chang, L., & Liu, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4296 · Cited by 36 · see citing works
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Horie, T., Nakao, T., Miyasaka, Y., Nishino, T., Matsumura, S., Nakazeki, F., Ide, Y., Kimura, M., Tsuji, S., Rodriguez, R. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21107-5 · Cited by 49 · see citing works
miRNA Regulation of Glucose and Lipid Metabolism in Relation to Diabetes and Non-alcoholic Fatty Liver Disease
Suksangrat, T., Phannasil, P., & Jitrapakdee, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_7 · Cited by 34 · see citing works
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches
Price, N. L., Goedeke, L., Suárez, Y., & Fernández‐Hernando, C. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012606 · Cited by 36 · see citing works
Self-citation
Potential role for microRNA in regulating hypoxia-induced metabolic suppression in jumbo squids
Hadj‐Moussa, H., Logan, S. M., Seibel, B. A., & Storey, K. B. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.04.007 · Cited by 30 · see citing works
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
Benito‐Vicente, A., Uribe, K. B., Rotllán, N., Ramírez, C. M., Jebari‐Benslaiman, S., Goedeke, L., Canfrán‐Duque, A., Galicia-García, U., de Urturi, D. S., Aspichueta, P., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228675 · Cited by 34 · see citing works
Self-citation
Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases
Formichi, C., Nigi, L., Grieco, G. E., Maccora, C., Fignani, D., Brusco, N., Licata, G., Sebastiani, G., & Dotta, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147716 · Cited by 33 · see citing works
The role of noncoding RNAs in metabolic reprogramming of cancer cells
Safi, A., Saberiyan, M., Sanaei, M., Adelian, S., Asl, F. D., Zeinaly, M., Shamsi, M., & Ahmadi, R. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00447-8 · Cited by 36 · see citing works
MicroRNA-33/33* inhibit the activation of MAVS through AMPK in antiviral innate immunity
Liu, D., Tan, Q., Zhu, J., Zhang, Y., Xue, Y., Song, Y., Liu, Y., Wang, Q., & Lai, L. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0326-x · Cited by 32 · see citing works
The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
Liao, W., Du, J., Wang, Z., Feng, Q., Liao, M., Liu, H., Yuan, K., & Zeng, Y. (2022) · International Journal of Cancer · doi:10.1002/ijc.34040 · Cited by 31 · see citing works
Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor
Srivastava, A., Shankar, K., Beg, M., Rajan, S., Gupta, A., Varshney, S., Kumar, D., Gupta, S., Mishra, R. K., & Gaikwad, A. N. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1623-z · Cited by 31 · see citing works
Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments
Reimunde, P., Pensado‐López, A., Crende, M. C., Iglesias, V. L., Sanchez, L. E., Torrecilla-Parra, M., Ramírez, C. M., Anfray, C., & Torres, F. (2021) · Cancers · doi:10.3390/cancers13051087 · Cited by 31 · see citing works
Self-citation
MMAB promotes negative feedback control of cholesterol homeostasis
Goedeke, L., Canfrán‐Duque, A., Rotllán, N., Chaube, B., Thompson, B. M., Lee, R. G., Cline, G. W., McDonald, J. G., Shulman, G. I., Lasunción, M. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26787-7 · Cited by 30 · see citing works
Self-citation
Analysis of MicroRNA Expression in Newborns with Differential Birth Weight Using Newborn Screening Cards
Rodil-García, P., Arellanes-Licea, E. D. C., Montoya-Contreras, A., & Salazar‐Olivo, L. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122552 · Cited by 30 · see citing works
Decoding microRNA drivers in atherosclerosis
Vartak, T., Kumaresan, S., & Brennan, E. (2022) · Bioscience Reports · doi:10.1042/bsr20212355 · Cited by 20 · see citing works
Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies.
Yang, P.-L., Rong, X.-L., Gao, Z., Wang, J.-J., & Liu, Z. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107588 · Cited by 29 · see citing works
miR-194 Promotes Burn-Induced Hyperglycemia via Attenuating IGF-IR Expression
Yu, Y., Chai, J., Zhang, H., Chu, W., Liu, L., Ma, L., Duan, H., Li, B., & Li, D. (2014) · Shock · doi:10.1097/shk.0000000000000258 · Cited by 29 · see citing works
MicroRNA‑24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin‑α3 and regulating inflammatory responses
Ye, Z., Li, Y., Liu, G., Qi, X., & Cao, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5355 · Cited by 29 · see citing works
A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue
de Almeida-Faria, J., Duque-Guimaraes, D. E., Carpenter, A. A. M., Loche, E., & Ozanne, S. E. (2017) · Scientific Reports · doi:10.1038/srep44949 · Cited by 29 · see citing works
Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
Arif, W., Datar, G. K., & Kalsotra, A. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.01.004 · Cited by 28 · see citing works
Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway
Shao, Z., Pan, Q., & Zhang, Y. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105789 · Cited by 28 · see citing works
Epigenetic regulation of inflammatory factors in adipose tissue
Jung, B. C., & Kang, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159019 · Cited by 28 · see citing works
MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARα in human hepatocellular carcinoma
Chang, W., Zhang, L., Xian, Y., & Yu, Z. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4236 · Cited by 27 · see citing works
The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration
Lauschke, V. M., Mkrtchian, S., & Ingelman-Sundberg, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.084 · Cited by 29 · see citing works
Correlation of circulating miRNA-33a and miRNA-122 with lipid metabolism among Egyptian patients with metabolic syndrome
Refeat, M. M., Hassan, N. A.-M., Ahmad, I. H., Mostafa, E. R. M., & Amr, K. S. (2021) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00246-8 · Cited by 24 · see citing works
miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression
Fernández-Tussy, P., Cardelo, M. P., Zhang, H., Sun, J., Price, N. L., Boutagy, N. E., Goedeke, L., Cadena-Sandoval, M., Xirouchaki, C. E., Brown, W., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.168476 · Cited by 21 · see citing works
Self-citation
Ageing influences the relationship of circulating miR-33a and miR - 33b levels with insulin resistance and adiposity
Corona-Meraz, F.-I., Mercado, M. V.-D., Ortega, F. J., Ruíz-Quezada, S. L., Guzmán-Ornelas, M.-O., & Navarro-Hernández, R. E. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118816659 · Cited by 22 · see citing works
Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases
Pomatto, M. A. C., Gai, C., Deregibus, M. C., Tetta, C., & Camussi, G. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4302096 · Cited by 22 · see citing works
MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., et al. (2018) · Oncology Letters · doi:10.3892/ol.2018.7892 · Cited by 21 · see citing works
“MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression”
Frutos, M. F.-D., Pardo, V., Torrecilla-Parra, M., Rada, P., Pérez-García, A., Martín-Martín, Y., de la Peña, G., Gómez, A., Toledano‐Zaragoza, A., Gómez‐Coronado, D., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2023.194938 · Cited by 21 · see citing works
Self-citation
3′-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and Glycogen Storage Disease type-Ia risk
Karthi, S., Rajeshwari, M., Francis, A., Matheshwaran, S., Varalakshmi, P., Houlden, H., Kumarasamy Thangaraj, K., & Ashokkumar, B. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.05.016 · Cited by 23 · see citing works
Nutriepigenomics and Malnutrition
Luca, A. D., Hankard, R., Borys, J.-M., Sinnett, D., Marcil, V., & Levy, E. H. (2017) · Epigenomics · doi:10.2217/epi-2016-0168 · Cited by 22 · see citing works
In low protein diets, microRNA-19b regulates urea synthesis by targeting SIRT5
Sun, R.-P., Xi, Q., Sun, J., Cheng, X., Zhu, Y., Ye, D.-Z., Chen, T., Wei, L.-M., Ye, R.-S., Jiang, Q., et al. (2016) · Scientific Reports · doi:10.1038/srep33291 · Cited by 20 · see citing works
Novel role of miR-33 in regulating of mitochondrial function
Price, N., & Fernández-Hernando, C. (2015) · Circulation Research · doi:10.1161/circresaha.117.306949 · Cited by 20 · see citing works
MicroRNA-Management of Lipoprotein Homeostasis
Sun, X., & Feinberg, M. W. (2014) · Circulation Research · doi:10.1161/circresaha.114.304228 · Cited by 19 · see citing works
microRNAs involved in psoriasis and cardiovascular diseases
Sileno, S., Beji, S., D'Agostino, M., Carassiti, A., Melillo, G., & Magenta, A. (2021) · Vascular Biology · doi:10.1530/vb-21-0007 · Cited by 13 · see citing works
MiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia.
Zhao, H., Liu, F., Jia, R., Chang, H., Li, H., Miao, M., Wang, H., & Yang, Z. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.8671 · Cited by 18 · see citing works
miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells
Jia, Q., Cao, Y., Zhang, M., Xing, Y., Xia, T., Guo, Y., Yue, Y.-X., Li, X., Liu, X., Zhang, Y., et al. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103200 · Cited by 17 · see citing works
ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation
Kim, K., Cho, E., Yu, S. J., Kang, H., Kim, Y.-J., Kim, S. H., & Lee, T. R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv735 · Cited by 17 · see citing works
miRNAs and High-Density Lipoprotein metabolism
Baldán, Á., & Vallim, T. Q. D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.021 · Cited by 17 · see citing works
miR-1224-5p Enhances Hepatic Lipogenesis by Targeting Adenosine Monophosphate–Activated Protein Kinase α1 in Male Mice
Chen, T., Yan, D., Cheng, X., Ji, X., Bian, J., & Yin, W. (2018) · Endocrinology · doi:10.1210/en.2017-03231 · Cited by 16 · see citing works

“Micromanaging” metabolic syndrome
Ramírez, C., Goedeke, L., & Fernández-Hernando, C. (2011) · Cell Cycle · doi:10.4161/cc.10.19.17558 · Cited by 27 · see citing works
Self-citation
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156 · see citing works
MicroRNAs in Metabolic Disease
Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.300144 · Cited by 257 · see citing works
Self-citation
A Regulatory Role for MicroRNA 33* in Controlling Lipid Metabolism Gene Expression
Goedeke, L., Vales-Lara, F. M., Fenstermaker, M., Cirera-Salinas, D., Chamorro-Jorganes, A., Ramírez, C. M., Mattison, J. A., de Cabo, R., Suárez, Y., & Fernández-Hernando, C. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01714-12 · Cited by 140 · see citing works
Self-citation
Meta-regulation: microRNA regulation of glucose and lipid metabolism
Lynn, F. C. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.05.007 · Cited by 187 · see citing works

Authors: Ramírez, C. M., Goedeke, L., Rotllan, N., Yoon, J.-H., Cirera-Salinas, D., Mattison, J. A., Suárez, Y., de Cabo, R., Gorospe, M., & Fernández-Hernando, C.
Affiliations: New York University (US)
Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York, USA
National Institutes of Health (US)
Translational Gerontology Branch, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA
ORCID: Ramírez, Cristina M.
Goedeke, Leigh
Yoon, Je-Hyun
Mattison, Julie A.
Suárez, Yajaira
Gorospe, Myriam
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2013-08-01
Volume: 33
Issue: 15
Pages: 2891-2902
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.00016-13
PMC: PMC3719675
OpenAlex: W2148995089
Cited by: 154
References: 46
Citations by year: 2026: 3 · 2025: 7 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 19 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 1
FWCI: 5.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (F31AG043318)
National Heart, Lung, and Blood Institute (R01HL105945, R01HL106063, R01HL107953)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: miR-33b, miR-33a, SREBP-1c, SREBP1, glucose metabolism, gluconeogenesis, PCK1, glucose-6-phosphatase, hepatic glucose production, post-transcriptional regulation, lipid metabolism, metabolic disorders, therapeutic target
MeSH terms: Animals, Gene Expression Regulation, Gluconeogenesis, Glucose, Glucose-6-Phosphatase, Glycogen, Humans, Macaca mulatta, Male, Phosphoenolpyruvate Carboxykinase (GTP), Hepatocytes, MicroRNAs, Intracellular Signaling Peptides and Proteins, Sterol Regulatory Element Binding Protein 1, Hep G2 Cells

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MicroRNA 33 Regulates Glucose Metabolism

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