Palczewski, Krzysztof

Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis

Kiser, P. D., Farquhar, E. R., Shi, W., Sui, X., Chance, M. R., & Palczewski, K. (2012) · Proceedings of the National Academy of Sciences

Enzyme Structure and FunctionPhotoreceptor and optogenetics research

Cited by 63

Membrane-binding and enzymatic properties of RPE65

Kiser, P. D., & Palczewski, K. (2010) · Progress in Retinal and Eye Research

Retinal Development and DisordersPhotoreceptor and optogenetics research

Cited by 62

Topology and Membrane Association of Lecithin: Retinol Acyltransferase

Moise, A. R., Golczak, M., Imanishi, Y., & Palczewski, K. (2007) · Journal of Biological Chemistry

Retinoids in leukemia and cellular processesLipid Membrane Structure and Behavior

Cited by 59

Lrat-specific domain facilitates Vitamin A metabolism by domain swapping in HRASLS3

Golczak, M., Sears, A. E., Kiser, P. D., & Palczewski, K. (2015) · Nature Chemical Biology

Enzyme Structure and FunctionRetinoids in leukemia and cellular processes

Cited by 58

Rhodopsin–transducin heteropentamer: Three-dimensional structure and biochemical characterization

Jastrzebska, B., Ringler, P., Lodowski, D. T., Moiseenkova-Bell, V., Golczak, M., Müller, S. A., Palczewski, K., & Engel, A. (2011) · Journal of Structural Biology

Receptor Mechanisms and SignalingPhotoreceptor and optogenetics research

Cited by 57

Stereoisomeric Specificity of the Retinoid Cycle in the Vertebrate Retina

Jang, G.-F., McBee, J. K., Alekseev, A. M., Haeseleer, F., & Palczewski, K. (2000) · Journal of Biological Chemistry

Retinoids in leukemia and cellular processesRetinal Development and Disorders

Cited by 53

Molecular Organization and ATP-Induced Conformational Changes of ABCA4, the Photoreceptor-Specific ABC Transporter

Tsybovsky, Y., Orban, T., Molday, R. S., Taylor, D., & Palczewski, K. (2013) · Structure

Drug Transport and Resistance MechanismsATP Synthase and ATPases Research

Cited by 53

Determinants shaping the nanoscale architecture of the mouse rod outer segment

Pöge, M., Mahamid, J., Imanishi, S. S., Plitzko, J. M., Palczewski, K., & Baumeister, W. (2021) · eLife

Retinal Development and DisordersAdvanced Electron Microscopy Techniques and Applications

Cited by 50

Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis

Sun, D., Sahu, B., Gao, S., Schur, R. M., Vaidya, A. M., Maeda, A., Palczewski, K., & Lu, Z.-R. (2017) · Molecular Therapy - Nucleic Acids

RNA Interference and Gene DeliveryRetinal Development and Disorders

Cited by 47

Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8- dihydroretinol

Moise, A. R., Isken, A., Domínguez, M., de Lera, A. R., von Lintig, J., & Palczewski, K. (2007) · Biochemistry

Retinoids in leukemia and cellular processesRetinal Development and Disorders

Cited by 45

Visualizing Water Molecules in Transmembrane Proteins Using Radiolytic Labeling Methods

Orban, T., Gupta, S., Palczewski, K., & Chance, M. R. (2010) · Biochemistry

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 45

From Atomic Structures to Neuronal Functions of G Protein–Coupled Receptors

Palczewski, K., & Orban, T. (2013) · Annual Review of Neuroscience

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 44

The rhodopsin-transducin complex houses two distinct rhodopsin molecules

Jastrzebska, B., Ringler, P., Palczewski, K., & Engel, A. (2013) · Journal of Structural Biology

Receptor Mechanisms and SignalingPhotoreceptor and optogenetics research

Cited by 42

QLT091001, a 9-cis-Retinal Analog, Is Well-Tolerated by Retinas of Mice with Impaired Visual Cycles

Maeda, T., Dong, Z., Jin, H., Sawada, O., Gao, S., Utkhede, D., Monk, W., Palczewska, G., & Palczewski, K. (2013) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 41

Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis, and Biological Evaluation of Dihydroretinoids

Moise, A. R., Domínguez, M., Alvarez, S., Alvarez, R., Schupp, M., Cristancho, A. G., Kiser, P. D., de Lera, A. R., Lazar, M. A., & Palczewski, K. (2008) · Journal of the American Chemical Society

Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated Receptors

Cited by 40

Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle

Sears, A. E., & Palczewski, K. (2016) · Biochemistry

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 40

Posttranslational Modifications of the Photoreceptor-Specific ABC Transporter ABCA4

Tsybovsky, Y., Wang, B., Quazi, F., Molday, R. S., & Palczewski, K. (2011) · Biochemistry

Retinal Development and DisordersDrug Transport and Resistance Mechanisms

Cited by 39

Dietary 9-cis-β,β-Carotene Fails to Rescue Vision in Mouse Models of Leber Congenital Amaurosis

Maeda, T., Perusek, L., Amengual, J., Babino, D., Palczewski, K., & von Lintig, J. (2011) · Molecular Pharmacology

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 37

Sequestration of Retinyl Esters Is Essential for Retinoid Signaling in the Zebrafish Embryo

Isken, A., Holzschuh, J., Lampert, J. M., Fischer, L., Oberhauser, V., Palczewski, K., & von Lintig, J. (2007) · Journal of Biological Chemistry

Retinoids in leukemia and cellular processesRetinal Development and Disorders

Cited by 37

Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition

Sander, C. L., Sears, A. E., Pinto, A. F. M., Choi, E. H., Kahremany, S., Gao, F., Salom, D., Jin, H., Pardon, E., Suh, S., et al. (2021) · Journal of Cell Biology

Lipid Membrane Structure and BehaviorLipid metabolism and biosynthesis

Cited by 36

Impact of Retinal Disease-Associated RPE65 Mutations on Retinoid Isomerization

Bereta, G., Kiser, P. D., Golczak, M., Sun, W., Heon, E., Saperstein, D. A., & Palczewski, K. (2008) · Biochemistry

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 36

Context-dependent compensation among phosphatidylserine-recognition receptors

Penberthy, K. K., Rival, C., Shankman, L. S., Raymond, M. H., Zhang, J., Perry, J. S. A., Lee, C. S., Han, C. Z., Onengut-Gumuscu, S., Palczewski, K., et al. (2017) · Scientific Reports

Phagocytosis and Immune RegulationAutophagy in Disease and Therapy

Cited by 30

Structural biology of 11- cis- retinaldehyde production in the classical visual cycle

Daruwalla, A., Choi, E. H., Palczewski, K., & Kiser, P. D. (2018) · Biochemical Journal

Photoreceptor and optogenetics researchRetinoids in leukemia and cellular processes

Cited by 28

An Acyl-covalent Enzyme Intermediate of Lecithin:Retinol Acyltransferase*

Golczak, M., & Palczewski, K. (2010) · Journal of Biological Chemistry

Retinoids in leukemia and cellular processesLipid metabolism and biosynthesis

Cited by 27