Mechanisms of inflammasome activation: recent advances and novel insights

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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Non-canonical inflammasome activation targets caspase-11

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Mechanisms and Functions of Inflammasomes

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Inflammatory caspases are innate immune receptors for intracellular LPS

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

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NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

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Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

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Regulation of inflammasome signaling

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Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

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Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

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Novel role of PKR in inflammasome activation and HMGB1 release

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Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

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Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

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NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

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IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

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The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

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Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

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Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

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FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

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Caspase-11 Protects Against Bacteria That Escape the Vacuole

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

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Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

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Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

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A functional role for NLRP6 in intestinal inflammation and tumorigenesis

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Central roles of NLRs and inflammasomes in viral infection

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Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

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Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

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Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

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The NLRP12 Inflammasome Recognizes Yersinia pestis

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Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

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Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS

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Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization

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RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

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Phosphorylation of NLRC4 is critical for inflammasome activation

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Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

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Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

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Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

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Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

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Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

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The PYHIN protein family as mediators of host defenses

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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

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Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

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Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

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Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

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Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

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Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

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Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

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Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1β in Response to TLR4 Stimulation through a Caspase-8– and TRIF-Dependent Pathway

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Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b

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Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

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Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen, Candida albicans

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Pyrin Levels in Human Monocytes and Monocyte-Derived Macrophages Regulate IL-1β Processing and Release

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Inflammasome Sensor Nlrp1b-Dependent Resistance to Anthrax Is Mediated by Caspase-1, IL-1 Signaling and Neutrophil Recruitment

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Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome

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Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

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The protein kinase PKR is critical for LPS‐induced iNOS production but dispensable for inflammasome activation in macrophages

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Anthrax Lethal Toxin Triggers the Formation of a Membrane-Associated Inflammasome Complex in Murine Macrophages

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