Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling
Open accessAbstract
An essential component of the ATR (ataxia telangiectasia-mutated and Rad3-related)-activating structure is single-stranded DNA. It has been suggested that nucleotide excision repair (NER) can lead to activation of ATR by generating such a signal, and in yeast, DNA damage processing through the NER pathway is necessary for checkpoint activation during G1. We show here that ultraviolet (UV) radiation-induced ATR signaling is compromised in XPA-deficient human cells during S phase, as shown by defects in ATRIP (ATR-interacting protein) translocation to sites of UV damage, UV-induced phosphorylation of Chk1 and UV-induced replication protein A phosphorylation and chromatin binding. However, ATR signaling was not compromised in XPC-, CSB-, XPF- and XPG-deficient cells. These results indicate that damage processing is not necessary for ATR-mediated S-phase checkpoint activation and that the lesion recognition function of XPA may be sufficient. In contrast, XP-V cells deficient in the UV bypass polymerase eta exhibited enhanced ATR signaling. Taken together, these results suggest that lesion bypass and not lesion repair may raise the level of UV damage that can be tolerated before checkpoint activation, and that XPA plays a critical role in this activation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ATRIP localization and Chk1 phosphorylation is not affected in XP-C, XP-F, and XP-G cells, but is affected in XP-A cells.
“However, Bomgarden et. al. showed that even though ATRIP localization and Chk1 phosphorylation is not affected in XP-C, XP-F, and XP-G cells, it is affected in XP-A cells [65].”
From ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle (2016) · cites this paper as [65]
Outside S phase and in non-cycling cells, UV lesions alone cannot activate the checkpoint; NER plays a major role in triggering the checkpoint response, though contrasting results exist.
“Outside of S phase and in non cycling cells the situation is quite different. Recent analysis showed that UV lesions themselves cannot activate the checkpoint and NER plays a major role in triggering the checkpoint response, although contrasting results have also been reported [52–57].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [53]
ATR is critical for UV DNA damage signaling and is linked with NER.
“ATR (ATM and Rad3-related) is critical to UV DNA damage signaling (Ciccia and Elledge, 2010) and is intimately linked with NER”
From RETRACTED: PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage (2014) · cites this paper as Bomgarden et al., 2006
XPA is part of the core NER incision complex and interacts with DNA and other NER and damage-response proteins.
“Xeroderma pigmentosum complement group A (XPA), a gene frequently mutated in XP patients, is part of the core incision complex of NER and interacts with DNA as well as many other NER and damage response proteins”
From RETRACTED: PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage (2014) · cites this paper as Bomgarden et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works
Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292 · see citing works
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122 · see citing works
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091 · see citing works
A role for ATR in the DNA damage-induced phosphorylation of p53
Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046 · see citing works
ATR and ATRIP: Partners in Checkpoint Signaling
Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works
Chapter 30 Cell Cycle Extracts
Murray, A. W. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60298-8 · Cited by 942 · see citing works
Nelson, W. G., & Kastan, M. B. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1815 · Cited by 850 · see citing works
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works
Sequential Assembly of the Nucleotide Excision Repair Factors In Vivo
Volker, M., Moné, M. J., Karmakar, P., van Hoffen, A., Schul, W., Vermeulen, W., Hoeijmakers, J. H. J., DRIEL, R. V., van Zeeland, A. A., & Mullenders, L. H. F. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00281-7 · Cited by 782 · see citing works
Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development · doi:10.1101/gad.1301205 · Cited by 767 · see citing works
Self-citationInterfaces Between the Detection, Signaling, and Repair of DNA Damage
Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 688 · see citing works
Lopes, M., Foiani, M., & Sogo, J. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.015 · Cited by 563 · see citing works
Initiating Cellular Stress Responses
Bakkenist, C. J., & Kastan, M. B. (2004) · Cell · doi:10.1016/j.cell.2004.06.023 · Cited by 544 · see citing works
Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 534 · see citing works
Self-citationEssential and dispensable roles of ATR in cell cycle arrest and genome maintenance
Brown, E. J., & Baltimore, D. (2003) · Genes & Development · doi:10.1101/gad.1067403 · Cited by 511 · see citing works
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint
Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498 · see citing works
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
Lehmann, A. (2003) · Biochimie · doi:10.1016/j.biochi.2003.09.010 · Cited by 496 · see citing works
A unified view of the DNA-damage checkpoint
Melo, J. A., & Toczyski, D. P. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00312-5 · Cited by 457 · see citing works
Subpathways of nucleotide excision repair and their regulation
Hanawalt, P. C. (2002) · Oncogene · doi:10.1038/sj.onc.1206096 · Cited by 447 · see citing works
Murray, A. W. (1991) · PubMed · Cited by 438 · see citing works
Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes & Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works
Mori, T., Nakane, M., Hattori, T., Matsunaga, T., Ihara, M., & Nikaido, O. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02010.x · Cited by 410 · see citing works
The G2-phase DNA-damage checkpoint
O’Connell, M. J., Walworth, N. C., & Carr, A. M. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01773-6 · Cited by 385 · see citing works
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
Melo, J. A., Cohen, J., & Toczyski, D. P. (2001) · Genes & Development · doi:10.1101/gad.903501 · Cited by 384 · see citing works
The eukaryotic nucleotide excision repair pathway
Costa, R. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.017 · Cited by 373 · see citing works
Checking on the fork: the DNA-replication stress-response pathway
Osborn, A. J., Elledge, S. J., & Zou, L. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02380-2 · Cited by 345 · see citing works
Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair
Prakash, S., & Prakash, L. (2002) · Genes & Development · doi:10.1101/gad.1009802 · Cited by 344 · see citing works
Replication Protein A phosphorylation and the cellular response to DNA damage
Binz, S. K., Sheehan, A. M., & Wold, M. S. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.028 · Cited by 299 · see citing works
Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms
Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., & Sugimoto, K. (2001) · Science · doi:10.1126/science.1063827 · Cited by 258 · see citing works
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication
Pacek, M., & Walter, J. C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600369 · Cited by 254 · see citing works
Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
Zachos, G., Rainey, M. D., & Gillespie, D. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg060 · Cited by 247 · see citing works
Ball, H. L., Myers, J. S., & Cortez, D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1006 · Cited by 241 · see citing works
Kumagai, A., Guo, Z., Emami, K. H., Wang, S. X., & Dunphy, W. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.6.1559 · Cited by 238 · see citing works
Limoli, C. L., Giedzinski, E., Bonner, W. M., & Cleaver, J. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231611798 · Cited by 210 · see citing works
Ward, I. M., Minn, K. T., & Chen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300554200 · Cited by 205 · see citing works
Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works
Hekmat-Nejad, M., You, Z., Yee, M., Newport, J. W., & Cimprich, K. A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00855-1 · Cited by 193 · see citing works
Self-citationp53 and regulation of DNA damage recognition during nucleotide excision repair
Adimoolam, S., & Ford, J. M. (2003) · DNA Repair · doi:10.1016/s1568-7864(03)00087-9 · Cited by 181 · see citing works
Self-citationDNA Repair Protein XPA Binds Replication Protein A (RPA)
Matsuda, T., Saijo, M., Kuraoka, I., Kobayashi, T., Nakatsu, Y., Nagai, A., Enjoji, T., Masutani, C., Sugasawa, K., Hanaoka, F., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4152 · Cited by 174 · see citing works
Transcription promotes contraction of CAG repeat tracts in human cells
Lin, Y., Dion, V., & Wilson, J. H. (2006) · Nature Structural &Molecular Biology · doi:10.1038/nsmb1042 · Cited by 169 · see citing works
A requirement for replication in activation of the ATR-dependent DNA damage checkpointPreprint
Lupardus, P. J., Byun, T. S., Yee, M., Hekmat-Nejad, M., & Cimprich, K. A. (2002) · Genes & Development · doi:10.1101/gad.1013502 · Cited by 163 · see citing works
Self-citationReplication of damaged DNA by translesion synthesis in human cells
Lehmann, A. R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.029 · Cited by 142 · see citing works
Bi, X., Slater, D., Ohmori, H., & Vaziri, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501562200 · Cited by 140 · see citing works
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
Giannattasio, M., Lazzaro, F., Longhese, M. P., Plevani, P., & Muzi‐Falconi, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600051 · Cited by 113 · see citing works
The Role of DNA Polymerase η in Translesion Synthesis Past Platinum–DNA Adducts in Human Fibroblasts
Bassett, E., King, N. M., Bryant, M. F., Hector, S., Pendyala, L., Chaney, S. G., & Cordeiro‐Stone, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1328 · Cited by 107 · see citing works
Barr, S. M., Leung, C. G., Chang, E. E., & Cimprich, K. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00376-2 · Cited by 104 · see citing works
Self-citationThe Cockayne Syndrome Group B Gene Product Is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Tuo, J., Jaruga, P., Rodriguez, H., Dizdaroğlu, M., & Bohr, V. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204814200 · Cited by 95 · see citing works
Neecke, H., Lucchini, G., & Pia Longhese, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.16.4485 · Cited by 94 · see citing works
G2 damage checkpoints: what is the turn-on?
O’Connell, M. J., & Cimprich, K. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01626 · Cited by 94 · see citing works
Self-citationZachos, G., Rainey, M. D., & Gillespie, D. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.563-574.2005 · Cited by 89 · see citing works
Functional Analysis of Human Replication Protein A in Nucleotide Excision Repair
Stigger, E., Drissi, R., & Lee, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.9337 · Cited by 84 · see citing works
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.
Cortez, D. (2005) · Genes & Development · doi:10.1101/gad.1316905 · Cited by 84 · see citing works
Fitch, M. E. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg031 · Cited by 79 · see citing works
Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences
Jiang, G., & Sancar, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.39-49.2006 · Cited by 70 · see citing works
Xeroderma pigmentosum variant and error-prone DNA polymerases
Kannouche, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.009 · Cited by 60 · see citing works
Kim, S.-M., Kumagai, A., Lee, J., & Dunphy, W. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508673200 · Cited by 58 · see citing works
A Novel Protein Activity Mediates DNA Binding of an ATR-ATRIP Complex
Bomgarden, R. D., Yean, D., Yee, M., & Cimprich, K. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311098200 · Cited by 50 · see citing works
Self-citationTransformation and immortalization of diploid xeroderma pigmentosum fibroblasts
Klein, B., Pastink, A., Odijk, H. J. H. M., et al. (1990) · Experimental Cell Research · doi:10.1016/0014-4827(90)90012-y · Cited by 42 · see citing works
Role of DNA Excision Repair Gene Defects in the Etiology of Cancer
Ford, J. M., & Hanawalt, P. C. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60505-5_5 · Cited by 35 · see citing works
Self-citationTranslesion DNA Synthesis: Little Fingers Teach Tolerance
Fleck, O., & Schär, P. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.014 · Cited by 26 · see citing works
Ichikawa, M., Nakane, H., Marra, G., Corti, C., Jiricny, J., Fitch, M., Ford, J. M., Ikejima, M., Shimada, T., Yoshino, M., et al. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00005-7 · Cited by 18 · see citing works
Self-citationGiannattasio, M., Lazzaro, F., Siede, W., Nunes, E., Plevani, P., & Muzi-Falconi, M. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.019 · Cited by 16 · see citing works
Chen, Z., Xu, X., Harrison, J. K., & Gan, W. A. N. G. (2004) · Biochemical Journal · doi:10.1042/bj20031143 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works
Hanasoge, S., & Ljungman, M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm157 · Cited by 216 · see citing works
Matsumoto, M., Yaginuma, K., Igarashi, A., Imura, M., Hasegawa, M., Iwabuchi, K., Date, T., Mori, T., Ishizaki, K., Yamashita, K., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.03391 · Cited by 138 · see citing works
Musich, P. R., & Zou, Y. (2009) · Aging · doi:10.18632/aging.100012 · Cited by 117 · see citing works
DNA nucleotide excision repair-dependent signaling to checkpoint activation
Marini, F., Nardo, T., Giannattasio, M., Minuzzo, M., Stefanini, M., Plevani, P., & Falconi, M. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605446103 · Cited by 114 · see citing works
Liu, Y., Wang, Y., Rusinol, A. E., Sinensky, M. S., Liu, J., Shell, S. M., & Zou, Y. (2008) · The FASEB Journal · doi:10.1096/fj.07-8598com · Cited by 115 · see citing works
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
Chou, W., Wang, H., Wong, F., Ding, S., Wu, P., Shieh, S., & Shen, C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.229 · Cited by 104 · see citing works
Checkpoint mechanisms at the intersection between DNA damage and repair
Lazzaro, F., Giannattasio, M., Puddu, F., Granata, M., Pellicioli, A., Plevani, P., & Muzi-Falconi, M. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.022 · Cited by 94 · see citing works
RETRACTED: PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage
Jarrett, S. G., Horrell, E. M. W., Christian, P. A., Vanover, J. C., Boulanger, M. C., Zou, Y., & D’Orazio, J. A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.030 · Cited by 85 · see citing works
RetractedXeroderma pigmentosum genes: Functions inside and outside DNA repair
Sugasawa, K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm282 · Cited by 83 · see citing works
Despras, E., Daboussi, F., Hyrien, O., Marheineke, K., & Kannouche, P. L. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq046 · Cited by 80 · see citing works
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells
Nishi, R., Alekseev, S., Dinant, C., Hoogstraten, D., Houtsmuller, A. B., Hoeijmakers, J. H. J., Vermeulen, W., Hanaoka, F., & Sugasawa, K. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.02.004 · Cited by 76 · see citing works
The 6-4 Photoproduct Is the Trigger of UV-Induced Replication Blockage and ATR Activation
Hung, K.-F., Sidorova, J. M., Nghiem, P., & Kawasumi, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917196117 · Cited by 64 · see citing works
Gilljam, K. M., Müller, R., Liabakk, N. B., & Otterlei, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049199 · Cited by 69 · see citing works
Yang, Z., Roginskaya, M., Colis, L. C., Basu, A. K., Shell, S. M., Liu, Y., Musich, P. R., Harris, C. M., Harris, T. M., & Zou, Y. (2006) · Biochemistry · doi:10.1021/bi061626q · Cited by 65 · see citing works
Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair
Lee, T.-H., Park, J.-M., Leem, S.-H., & Kang, T.-H. (2014) · Oncogene · doi:10.1038/onc.2012.539 · Cited by 61 · see citing works
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
Lindsey-Boltz, L. A., Kemp, M. G., Reardon, J. T., DeRocco, V., Iyer, R. R., Modrich, P., & Sancar, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.542787 · Cited by 59 · see citing works
Lerner, L. K., Francisco, G., Soltys, D. T., Rocha, C. R. R., Quinet, A., Vessoni, A. T., Castro, L. P., David, T. I. P., Bustos, S. O., Strauss, B. E., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1196 · Cited by 53 · see citing works
Postreplication gaps at UV lesions are signals for checkpoint activation
Callegari, A. J., Clark, E., Pneuman, A., & Kelly, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003449107 · Cited by 54 · see citing works
Ray, A., Blevins, C., Wani, G., & Wani, A. A. (2016) · PLOS ONE · doi:10.1371/journal.pone.0159344 · Cited by 44 · see citing works
Mind the gap: keeping UV lesions in check
Novarina, D., Amara, F., Lazzaro, F., Plevani, P., & Muzi-Falconi, M. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.04.030 · Cited by 43 · see citing works
Low, G. K. M., Fok, E. D. Z., Ting, A. P. L., & Hande, M. P. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.009 · Cited by 27 · see citing works
Role of Claspin in regulation of nucleotide excision repair factor DDB2
Prætorius-Ibba, M., Wang, Q.-E., Wani, G., El-Mahdy, M. A., Zhu, Q., Qin, S., & Wani, A. A. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.009 · Cited by 24 · see citing works
Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23 · see citing works
- Authors
- Bomgarden, R. D., Lupardus, P. J., Soni, D. V., Yee, M., Ford, J. M., & Cimprich, K. A.
- Affiliations
- Stanford University (US)
- Stanford Medicine (US)
- Corresponding author
- Cimprich, Karlene A
- Venue
- The EMBO Journal
- Published
- 2006-05-04
- Volume
- 25
- Issue
- 11
- Pages
- 2605-2614
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1478198
- OpenAlex
- W2062564859
- Cited by
- 87
- References
- 67
- Citations by year
- 2023: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 7
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Update notices
- erratum (2006-10-18)
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Leukemia and Lymphoma Society
- National Institutes of Health
- National Institute of General Medical Sciences (GM62193, R01GM062193)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- XPA, XPG, XPC, XPD
- MeSH terms
- Checkpoint Kinase 1, Poly-ADP-Ribose Binding Proteins, Y-Family DNA Polymerases, Animals, Cell Cycle, Cell Line, DNA, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Helicases, DNA-Binding Proteins, Exodeoxyribonucleases, Humans, Oocytes, Phosphoproteins, Protein Kinases, Ultraviolet Rays, Xenopus laevis, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Xenopus Proteins, DNA Repair Enzymes, Adaptor Proteins, Signal Transducing, Mice, Xeroderma Pigmentosum Group A Protein, Ataxia Telangiectasia Mutated Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
