Kagan, Valerian E.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 7,695

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 4,293

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 3,732

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology

Ferroptosis and cancer prognosisAntioxidant Activity and Oxidative Stress

Cited by 3,029

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., et al. (2022) · Nature Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,514

Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

Shvedova, A. A., Kisin, E. R., Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. I., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Occupational and environmental lung diseasesGraphene and Nanomaterials Applications

Cited by 1,312

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., et al. (2005) · Nature Chemical Biology

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 1,256

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 1,083

Regulation of lipid peroxidation and ferroptosis in diverse species

Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development

Ferroptosis and cancer prognosisAntioxidant Activity and Oxidative Stress

Cited by 544

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

Hüttemann, M., Pecina, P., Rainbolt, M., Sanderson, T. H., Kagan, V. E., Samavati, L., Doan, J. W., & Lee, I. (2011) · Mitochondrion

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 522

Peroxidase Activity and Structural Transitions of Cytochrome c Bound to Cardiolipin-Containing Membranes

Belikova, N. A., Vladimirov, Y. A., Osipov, A. N., Kapralov, A. A., Tyurin, V. A., Potapovich, M. V., Basova, L. V., Peterson, J., Kurnikov, I. V., & Kagan, V. E. (2006) · Biochemistry

Cell death mechanisms and regulationLipid Membrane Structure and Behavior

Cited by 398

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Sun, W.-Y., Tyurin, V. A., Mikulska-Ruminska, K., Shrivastava, I. H., Anthonymuthu, T. S., Zhai, Y.-J., Pan, M.-H., Gong, H.-B., Lu, D.-H., Sun, J., et al. (2021) · Nature Chemical Biology

Ferroptosis and cancer prognosisNeurological diseases and metabolism

Cited by 337

Oxidized lipids block antigen cross-presentation by dendritic cells in cancer

Cao, W., Ramakrishnan, R., Tuyrin, V. A., Veglia, F., Condamine, T., Amoscato, A., Mohammadyani, D., Johnson, J. J., Min Zhang, L., Klein-Seetharaman, J., et al. (2014) · The Journal of Immunology

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 302

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Dar, H. H., Tyurina, Y. Y., Mikulska-Ruminska, K., Shrivastava, I., Ting, H.-C., Tyurin, V. A., Krieger, J., St. Croix, C. M., Watkins, S., Bayir, E., et al. (2018) · Journal of Clinical Investigation

Ferroptosis and cancer prognosisBacterial biofilms and quorum sensing

Cited by 251

Cardiolipin Switch in Mitochondria: Shutting off the Reduction of Cytochrome c and Turning on the Peroxidase Activity

Basova, L. V., Kurnikov, I. V., Wang, L., Ritov, V. B., Belikova, N. A., Vlasova, I. I., Pacheco, A. A., Winnica, D. E., Peterson, J., Bayir, H., et al. (2007) · Biochemistry

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 212

Starving Neurons Show Sex Difference in Autophagy

Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., et al. (2009) · Journal of Biological Chemistry

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 204

PLA2G6 guards placental trophoblasts against ferroptotic injury

Beharier, O., Tyurin, V. A., Goff, J. P., Guerrero-Santoro, J., Kajiwara, K., Chu, T., Tyurina, Y. Y., St Croix, C. M., Wallace, C. T., Parry, S., et al. (2020) · Proceedings of the National Academy of Sciences

Ferroptosis and cancer prognosisPregnancy and preeclampsia studies

Cited by 198

Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria

Bayir, H., Fadeel, B., Palladino, M. J., Witasp, E., Kurnikov, I. V., Tyurina, Y. Y., Tyurin, V. A., Amoscato, A. A., Jiang, J., Kochanek, P. M., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 175

Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation

Reznick, A. Z., Kagan, V. E., Ramsey, R., Tsuchiya, M., Khwaja, S., Serbinova, E. A., & Packer, L. (1992) · Archives of Biochemistry and Biophysics

Cardiac Ischemia and ReperfusionNeuroprotection in Cerebral Ischemia

Cited by 171

Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice

Shvedova, A. A., Kisin, E. R., Murray, A. R., Gorelik, O., Arepalli, S., Castranova, V., Young, S.-H., Gao, F., Tyurina, Y. Y., Oury, T. D., et al. (2007) · Toxicology and Applied Pharmacology

Occupational and environmental lung diseasesAntioxidant Activity and Oxidative Stress

Cited by 163

Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS

Bayır, H., Kagan, V. E., Borisenko, G. G., Tyurina, Y. Y., Janesko, K. L., Vagni, V. A., Billiar, T. R., Williams, D. L., & Kochanek, P. M. (2005) · Journal of Cerebral Blood Flow & Metabolism

Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Cited by 138

Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Fitz, N. F., Nam, K. N., Wolfe, C. M., Letronne, F., Playso, B. E., Iordanova, B. E., Kozai, T. D. Y., Biedrzycki, R. J., Kagan, V. E., Tyurina, Y. Y., et al. (2021) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 129

Elevated Levels of S -Nitrosoalbumin in Preeclampsia Plasma

Tyurin, V. A., Liu, S.-X., Tyurina, Y. Y., Sussman, N. B., Hubel, C. A., Roberts, J. M., Taylor, R. N., & Kagan, V. E. (2001) · Circulation Research

Pregnancy and preeclampsia studiesNitric Oxide and Endothelin Effects

Cited by 120

Peroxidase Activity of Hemoglobin·Haptoglobin Complexes

Kapralov, A., Vlasova, I. I., Feng, W., Maeda, A., Walson, K., Tyurin, V. A., Huang, Z., Aneja, R. K., Carcillo, J., Bayır, H., et al. (2009) · Journal of Biological Chemistry

Hemoglobin structure and functionHeme Oxygenase-1 and Carbon Monoxide

Cited by 96