Gerszten, Robert E.

Metabolite profiles and the risk of developing diabetes

Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 3,143

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 2,820

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Taliun, D., Harris, D. N., Kessler, M. D., Carlson, J., Szpiech, Z. A., Torres, R., Taliun, S. A. G., Corvelo, A., Gogarten, S. M., Kang, H. M., et al. (2021) · Nature

Genetic Associations and EpidemiologyGenomics and Rare Diseases

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MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science

Cholesterol and Lipid MetabolismMicroRNA in disease regulation

Cited by 957

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 948

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 927

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., Szeto, M. D., Liao, X., Leventhal, M. J., Nasser, J., et al. (2020) · Nature

Acute Myeloid Leukemia ResearchGenetic Associations and Epidemiology

Cited by 733

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

Rhee, E. P., Cheng, S., Larson, M. G., Walford, G. A., Lewis, G. D., McCabe, E., Yang, E., Farrell, L., Fox, C. S., O’Donnell, C. J., et al. (2011) · Journal of Clinical Investigation

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolomics and Mass Spectrometry Studies

Cited by 647

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 643

Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion

Tateishi, K., Wakimoto, H., Iafrate, A. J., Tanaka, S., Loebel, F., Lelic, N., Wiederschain, D., Bedel, O., Deng, G., Zhang, B., et al. (2015) · Cancer Cell

Cancer, Hypoxia, and MetabolismBiochemical and Molecular Research

Cited by 433

Metabolic signatures of exercise in human plasma

Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M., Arany, Z., Rowe, G. C., Souza, A., Cheng, S., McCabe, E. L., Yang, E., et al. (2010) · Science Translational Medicine

Metabolomics and Mass Spectrometry StudiesCardiovascular and exercise physiology

Cited by 432

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., Carr, S. A., Thadhani, R., Gerszten, R. E., & Mootha, V. K. (2008) · Molecular Systems Biology

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 399

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

Rhee, E. P., Clish, C. B., Ghorbani, A., Larson, M. G., Elmariah, S., McCabe, E., Yang, Q., Cheng, S., Pierce, K., Deik, A., et al. (2013) · Journal of the American Society of Nephrology

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

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Genetic Architecture of Insulin Resistance in the Mouse

Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 249

Metabolomics and Cardiovascular Biomarker Discovery

Rhee, E. P., & Gerszten, R. E. (2012) · Clinical Chemistry

Metabolomics and Mass Spectrometry StudiesHealth, Environment, Cognitive Aging

Cited by 232

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

Katz, D. H., Robbins, J. M., Deng, S., Tahir, U. A., Bick, A. G., Pampana, A., Yu, Z., Ngo, D., Benson, M. D., Chen, Z.-Z., et al. (2022) · Science Advances

Advanced Biosensing Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 206

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Warren, C. R., O’Sullivan, J. F., Friesen, M., Becker, C. E., Zhang, X., Liu, P., Wakabayashi, Y., Morningstar, J. E., Shi, X., Choi, J., et al. (2017) · Cell stem cell

Pluripotent Stem Cells ResearchGenetic Associations and Epidemiology

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Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

Raffield, L. M., Dang, H., Pratte, K. A., Jacobson, S., Gillenwater, L. A., Ampleford, E., Barjaktarevic, I., Basta, P., Clish, C. B., Comellas, A. P., et al. (2020) · PROTEOMICS

Advanced Biosensing Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

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Stability and reproducibility of proteomic profiles in epidemiological studies: comparing the Olink and SOMAscan platforms

Haslam, D. E., Li, J., Dillon, S. T., Gu, X., Cao, Y., Zeleznik, O. A., Sasamoto, N., Zhang, X., Eliassen, A. H., Liang, L., et al. (2022) · PROTEOMICS

Advanced Biosensing Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

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Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR

Rottiers, V., Obad, S., Petri, A., McGarrah, R., Lindholm, M. W., Black, J. C., Sinha, S., Goody, R. J., Lawrence, M. S., deLemos, A. S., et al. (2013) · Science Translational Medicine

MicroRNA in disease regulationRNA Interference and Gene Delivery

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Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease

Kahn, D., Macias, E., Zarini, S., Garfield, A., Zemski Berry, K., MacLean, P., Gerszten, R. E., Libby, A., Solt, C., Schoen, J., et al. (2022) · Endocrinology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD

Corey, K. E., Pitts, R., Lai, M., Loureiro, J., Masia, R., Osganian, S. A., Gustafson, J. L., Hutter, M. M., Gee, D. W., Meireles, O. R., et al. (2022) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

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The HERITAGE family study: a review of the effects of exercise training on cardiometabolic health, with insights into molecular transducers

SARZYNSKI, M. A., RICE, T. K., DESPRÉS, J.-P., PÉRUSSE, L., TREMBLAY, A., STANFORTH, P. R., TCHERNOF, A., BARBER, J. L., FALCIANI, F., CLISH, C., et al. (2022) · Medicine & Science in Sports & Exercise

Cardiovascular and exercise physiologyGenetics and Physical Performance

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Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea

Kosyakovsky, L. B., Liu, E. E., Wang, J. K., Myers, L., Parekh, J. K., Knauss, H., Lewis, G. D., Malhotra, R., Nayor, M., Robbins, J. M., et al. (2024) · Circulation: Heart Failure

Heart Failure Treatment and ManagementCardiovascular Function and Risk Factors

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