Neuronal regulation of homeostasis by nutrient sensing

Insulin signalling and the regulation of glucose and lipid metabolism

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Ghrelin induces adiposity in rodents

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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Cellular mechanisms of insulin resistance

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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

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Hypothalamic mTOR Signaling Regulates Food Intake

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Gastrointestinal regulation of food intake

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Hypothalamic insulin signaling is required for inhibition of glucose production

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Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works

Gut hormones and the regulation of energy homeostasis

Murphy, K. G., & Bloom, S. R. (2006) · Nature · doi:10.1038/nature05484 · Cited by 778 · see citing works

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

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Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

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A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

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Hypothalamic KATP channels control hepatic glucose production

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The Hormonal Control of Food Intake

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Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

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Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

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The gut and energy balance: visceral allies in the obesity wars

Badman, M. K., & Flier, J. S. (2005) · Science · doi:10.1126/science.1109951 · Cited by 532 · see citing works

Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver

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Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

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Ghrelin action in the brain controls adipocyte metabolism

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The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

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Central insulin action in energy and glucose homeostasis

Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29063 · Cited by 438 · see citing works

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

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GOAT links dietary lipids with the endocrine control of energy balance

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The Lipid Messenger OEA Links Dietary Fat Intake to Satiety

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Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

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Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism

Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341 · see citing works

Intestinal Gluconeogenesis Is a Key Factor for Early Metabolic Changes after Gastric Bypass but Not after Gastric Lap-Band in Mice

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Role of hepatic STAT3 in brain-insulin action on hepatic glucose production

Inoue, H., Ogawa, W., Asakawa, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.009 · Cited by 294 · see citing works

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production

Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 293 · see citing works

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons

Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292 · see citing works

Central insulin action regulates peripheral glucose and fat metabolism in mice

Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 270 · see citing works

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., Lee, C. E., Elmquist, J. K., Yoshimura, A., & Flier, J. S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.010 · Cited by 242 · see citing works

Molecular disruption of hypothalamic nutrient sensing induces obesity

He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233 · see citing works

Is Type 2 Diabetes an Operable Intestinal Disease?

Rubino, F. (2008) · Diabetes Care · doi:10.2337/dc08-s271 · Cited by 231 · see citing works

Critical role of STAT3 in leptin's metabolic actions

Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228 · see citing works

Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X.-H., & Bjørbæk, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.05.003 · Cited by 226 · see citing works

Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

Shiuchi, T., Haque, M. S., Okamoto, S., Inoue, T., Kageyama, H., Lee, S., Toda, C., Suzuki, A., Bachman, E. S., Kim, Y., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.013 · Cited by 225 · see citing works

Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211 · see citing works

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419511 · Cited by 210 · see citing works

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

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Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery

Cummings, D. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.15 · Cited by 203 · see citing works

The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans

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Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ

Lam, T. K. T., Yoshii, H., Haber, C. A., Bogdanovic, E., Lam, L., Fantus, I. G., & Giacca, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00038.2002 · Cited by 195 · see citing works

Insulin's direct effects on the liver dominate the control of hepatic glucose production

Edgerton, D. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27073 · Cited by 194 · see citing works

Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated

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Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

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Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

Cheung, G. W. C., Kokorovic, A., Lam, C., Chari, M., & Lam, T. K. T. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.005 · Cited by 179 · see citing works

Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.

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Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance

Pocai, A., Morgan, K., Buettner, C., Gutierrez-Juarez, R., Obici, S., & Rossetti, L. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3182 · Cited by 153 · see citing works

Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins

Lam, T. K. T., Juárez, R. G., Pocai, A., Bhanot, S., Tso, P., Schwartz, G. J., & Rossetti, L. (2007) · Nature Medicine · doi:10.1038/nm1540 · Cited by 151 · see citing works

N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake

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A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog

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A Role for Hypothalamic Malonyl-CoA in the Control of Food Intake

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Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing

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The Role of CNS Fuel Sensing in Energy and Glucose Regulation

Cota, D., Proulx, K., & Seeley, R. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.049 · Cited by 117 · see citing works

CNS Regulation of Glucose Homeostasis

Lam, C., Chari, M., & Lam, T. K. T. (2009) · Physiology · doi:10.1152/physiol.00003.2009 · Cited by 110 · see citing works

Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin

van den Hoek, A. M., Voshol, P. J., Karnekamp, B. N., Buijs, R. M., Romijn, J. A., Havekes, L. M., & Pijl, H. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2529 · Cited by 109 · see citing works

Intraduodenal infusions of fats elicit satiety in sham-feeding rats

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Targeting the CNS to treat type 2 diabetes

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Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J mice

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Central Nervous System Neuropeptide Y Signaling Modulates VLDL Triglyceride Secretion

Stafford, J. M., Yu, F., Printz, R. L., Hasty, A. H., Swift, L. L., & Niswender, K. D. (2008) · Diabetes · doi:10.2337/db07-1702 · Cited by 81 · see citing works

Central lactate metabolism regulates food intake

Lam, C., Chari, M., Wang, P. Y. T., & Lam, T. K. T. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90481.2008 · Cited by 80 · see citing works

Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway

Cha, S. H., & Lane, M. D. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.017 · Cited by 76 · see citing works

A Balance of Lipid-Sensing Mechanisms in the Brain and Liver

Caspi, L., Wang, P. Y. T., & Lam, T. K. T. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.005 · Cited by 58 · see citing works

Hypothalamic Protein Kinase C Regulates Glucose Production

Ross, R., Wang, P. Y. T., Chari, M., Lam, C., Caspi, L., Ono, H., Muse, E. D., Li, X., Juárez, R. G., Light, P. E., et al. (2008) · Diabetes · doi:10.2337/db08-0206 · Cited by 57 · see citing works

Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance.

Chari, M., Lam, C. K. L., Wang, P. Y. T., & Lam, T. K. T. (2008) · Diabetes · doi:10.2337/db07-1464 · Cited by 53 · see citing works

Mice with chronically increased circulating ghrelin develop age-related glucose intolerance.

Reed, J. A., Benoit, S., Pfluger, P., Tschöp, M., D'Alessio, D., & Seeley, R. (2008) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00463.2007 · Cited by 46 · see citing works

Regulation of intracellular pH by cultured opossum kidney cells

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Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation

Chakravarthy, M. V., Zhu, Y., Li, Y., Coleman, T., Pappan, K. L., Marshall, C. A., McDaniel, M. L., & Semenkovich, C. F. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800379-jlr200 · Cited by 45 · see citing works

Neurobiology of food intake in health and disease

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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

López, M., Varela, L., Vazquez, M. J., Rodríguez‐Cuenca, S., González, C. R., Velagapudi, V., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2207 · Cited by 682 · see citing works

SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

Ferrannini, E., & Solini, A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.243 · Cited by 459 · see citing works

Biology's response to dieting: the impetus for weight regain

MacLean, P. S., Bergouignan, A., Cornier, M., & Jackman, M. R. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00755.2010 · Cited by 449 · see citing works

Metformin Activates a Duodenal Ampk-Dependent Pathway to Lower Hepatic Glucose Production in Rats

Duca, F. A., Côté, C. D., Rasmussen, B. A., Zadeh-Tahmasebi, M., Rutter, G. A., Filippi, B. M., & Lam, T. K. T. (2015) · Nature Medicine · doi:10.1038/nm.3787 · Cited by 402 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C. R., Ding, H., Lam, K. S. L., & Xu, A. (2014) · Diabetes · doi:10.2337/db14-0541 · Cited by 299 · see citing works

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

Breen, D. M., Rasmussen, B. A., Kokorovic, A., Wang, R., Cheung, G. W. C., & Lam, T. K. T. (2012) · Nature Medicine · doi:10.1038/nm.2745 · Cited by 209 · see citing works

The role for adipose tissue in weight regain after weight loss

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Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity

Hopkins, M., & Blundell, J. E. (2016) · Clinical Science · doi:10.1042/cs20160006 · Cited by 212 · see citing works

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

Guillemot‐Legris, O., Masquelier, J., Everard, A., Cani, P. D., Alhouayek, M., & Muccioli, G. G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0666-8 · Cited by 168 · see citing works

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

Jauch‐Chara, K., Friedrich, A., Rezmer, M., Melchert, U. H., Scholand-Engler, H. G., Hallschmid, M., & Oltmanns, K. M. (2012) · Diabetes · doi:10.2337/db12-0025 · Cited by 164 · see citing works

The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus

Lee, C. B., Chae, S. U., Jo, S. J., Jerng, U. M., & Bae, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073566 · Cited by 149 · see citing works

Metabolic Sensing and the Brain: Who, What, Where, and How?

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The gut–brain dopamine axis: a regulatory system for caloric intake

de Araujo, I. E., Ferreira, J. G., Tellez, L. A., Ren, X., & Yeckel, C. W. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.026 · Cited by 140 · see citing works

The metabolic role of vagal afferent innervation

Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0062-1 · Cited by 140 · see citing works

SGLT2 Inhibition for the Prevention and Treatment of Diabetic Kidney Disease: A Review

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Maintenance of Homeostasis in the Aging Hypothalamus: The Central and Peripheral Roles of Succinate

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Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia

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