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Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis

Ke, H., Li, F., Deng, W., Li, Z., Wang, S., Lv, P., & Chen, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.726707 · Cited by 91 · see citing works

Effects of metformin, acarbose, and sitagliptin monotherapy on gut microbiota in Zucker diabetic fatty rats

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Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight

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Mechanisms of action of metformin with special reference to cardiovascular protection

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The Gut Microbiome: Connecting Diet, Glucose Homeostasis, and Disease

Howard, E. J., Lam, T. K. T., & Duca, F. A. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-042220-012821 · Cited by 87 · see citing works

Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study

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Gut Microbiome: Profound Implications for Diet and Disease

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Metformin acts in the gut and induces gut-liver crosstalk

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Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

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A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE

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Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats

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The Gut Microbiome, Metformin, and Aging

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Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin

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Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease

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Dietary fibers as emerging nutritional factors against diabetes: focus on the involvement of gut microbiota

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Understanding the action mechanisms of metformin in the gastrointestinal tract

Cheng, M., Ren, L., Jia, X., Wang, J., & Cong, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1347047 · Cited by 70 · see citing works

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

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Exposure to prescribed medication in early life and impacts on gut microbiota and disease development

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Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

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Gut Microbiota and Antidiabetic Drugs: Perspectives of Personalized Treatment in Type 2 Diabetes Mellitus

Liu, W., Luo, Z., Zhou, J., & Sun, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.853771 · Cited by 62 · see citing works

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

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Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption

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Lipopolysaccharide promotes metastasis via acceleration of glycolysis by the nuclear factor-κB/snail/hexokinase3 signaling axis in colorectal cancer

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From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease

Liu, H., Huang, Y., Huang, M., Wang, M., Ming, Y., Chen, W., Chen, Y., Tang, Z., & Jia, B. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01413-y · Cited by 58 · see citing works

The Role of the Microbiome in Drug Response

Pryor, R. E., Martínez‐Martínez, D., Quintaneiro, L. M., & Cabreiro, F. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023612 · Cited by 58 · see citing works

FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats

Zhang, S., Li, R. J. W., Lim, Y.-M., Batchuluun, B., Liu, H., Waise, T. M. Z., & Lam, T. K. T. (2020) · Gut · doi:10.1136/gutjnl-2020-321757 · Cited by 58 · see citing works

Pharmacologic and Nonpharmacologic Therapies for the Gut Microbiota in Type 2 Diabetes

Caesar, R. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.01.007 · Cited by 57 · see citing works

Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers

Cao, C., Yue, S., Lü, A., & Liang, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107321 · Cited by 59 · see citing works

Role of gut microbiota in the pathogenesis and treatment of diabetes mullites: Advanced research-based review

Ye, J., Wu, Z., Zhao, Y., Zhang, S., Liu, W.-T., & Su, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1029890 · Cited by 55 · see citing works

Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass

Laferrère, B., & Pattou, F. N. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00530 · Cited by 54 · see citing works

Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Glucose Metabolism Accompanied by the Modulation of Gut Microbiota and Ileal Inflammatory Damage in Type 2 Diabetic KKAy Mice

Liu, Q., Liu, S., Cao, H., Ji, W., Li, C., Huan, Y., Lei, L., Fu, Y., Gao, X., Liu, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.642400 · Cited by 53 · see citing works

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice

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A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

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Dapagliflozin Modulates the Fecal Microbiota in a Type 2 Diabetic Rat Model

Yang, M., Shi, F., Liu, W., Zhang, M.-C., Feng, R., Cheng, Q., Liu, W., & Ma, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00635 · Cited by 51 · see citing works

Metformin elicits antitumour effect by modulation of the gut microbiota and rescues Fusobacterium nucleatum-induced colorectal tumourigenesis

Huang, X., Hong, X., Wang, J., Sun, T., Yu, T., Yu, Y., Fang, J., & Xiong, H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103037 · Cited by 50 · see citing works

Effects of Non-insulin Anti-hyperglycemic Agents on Gut Microbiota: A Systematic Review on Human and Animal Studies

Cao, T. T. B., Wu, K., Hsu, J., Chang, C., Chou, C., Lin, C.-Y., Liao, Y.-M., Lin, P.-C., Yang, L., & Lin, H. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.573891 · Cited by 49 · see citing works

Reg3γ: current understanding and future therapeutic opportunities in metabolic disease

Shin, J. H., Bozadjieva-Kramer, N., & Seeley, R. J. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01054-5 · Cited by 48 · see citing works

Amelioration of metabolic syndrome by metformin associates with reduced indices of low-grade inflammation independently of the gut microbiota

Adeshirlarijaney, A., Zou, J., Tran, H. Q., Chassaing, B., & Gewirtz, A. T. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00245.2019 · Cited by 46 · see citing works

Mechanisms of gut microbiota-immune-host interaction on glucose regulation in type 2 diabetes

Zhou, Y.-D., Liang, F.-X., Tian, H.-R., Luo, D., Wang, Y., & Yang, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1121695 · Cited by 45 · see citing works

Gut Microbiota−Tryptophan Metabolism−GLP-1 Axis Participates in β-Cell Regeneration Induced by Dapagliflozin

Jiang, Y., Yang, J., Li, X., Wei, T., Cui, X., Wang, D., Jin, Z., Lin, X., Li, F., Yang, K., et al. (2024) · Diabetes · doi:10.2337/db23-0553 · Cited by 45 · see citing works

Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy

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Biomimetic nanoplatform with microbiome modulation and antioxidant functions ameliorating insulin resistance and pancreatic β-cell dysfunction for T2DM management

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A system biology perspective on environment–host–microbe interactions

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Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity

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Metformin Affects Gut Microbiota Composition and Diversity Associated with Amelioration of Dextran Sulfate Sodium-Induced Colitis in Mice

Liu, Z., Liao, W., Zhang, Z., Sun, R., Luo, Y., Chen, Q., Li, X., Lu, R., & Ying, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.640347 · Cited by 42 · see citing works

The Gut Microbiota-Related Antihyperglycemic Effect of Metformin

Szymczak-Pajor, I., Drzewoski, J., Kozłowska, M., Krekora, J., & Śliwińska, A. (2025) · Pharmaceuticals · doi:10.3390/ph18010055 · Cited by 41 · see citing works

Frailty and HIV: Moving from Characterization to Intervention

Erlandson, K. M., & Piggott, D. A. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00554-1 · Cited by 41 · see citing works

Oligofructose improves small intestinal lipid-sensing mechanisms via alterations to the small intestinal microbiota

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Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota

Wang, Y., Jia, X., & Cong, B. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1396031 · Cited by 37 · see citing works

The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities

Zhang, K., Zhang, Q., Qiu, H., Ma, Y., Hou, N., Zhang, J., Kan, C., Han, F., Sun, X., & Shi, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37609 · Cited by 39 · see citing works

Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes

Fujiwara, Y., Eguchi, S., Murayama, H., Takahashi, Y., Toda, M., Imai, K., & Tsuda, K. (2019) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.68 · Cited by 39 · see citing works

Characterizing the bacterial community across the gastrointestinal tract of goats: Composition and potential function

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Early-life supplementation of grape polyphenol extract promotes polyphenol absorption and modulates the intestinal microbiota in association with the increase in mRNA expression of the key intestinal barrier genes

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Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial

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Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ

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Characterization of gut microbiota associated with metabolic syndrome and type-2 diabetes mellitus in Mexican pediatric subjects

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Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders

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Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling

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Obesity and the gut microbiota: implications of neuroendocrine and immune signaling

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Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats

Waise, T. M. Z., Lim, Y.-M., Danaei, Z., Zhang, S., & Lam, T. K. T. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101132 · Cited by 32 · see citing works

The upper small intestinal microbiota regulates nutrient sensing pathways to influence glucose homeostasis

Bauer, P. V. (2018) · TSpace (University of Toronto)

Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis

Bauer, P. V., Duca, F. A., Waise, T. M. Z., Dranse, H. J., Rasmussen, B. A., Puri, A., Rasti, M., O'Brien, C. A., & Lam, T. K. T. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.013 · Cited by 104 · see citing works

Metformin and intestinal microbiota

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Sugar, drugs, and gut bugs

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Lactobacillus Gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid Sensing Pathway That Regulates Whole-Body Glucose Homeostasis

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