Cited by 140Regulation of Appetite and ObesityVagus Nerve Stimulation ResearchGastrointestinal motility and disorders

The metabolic role of vagal afferent innervation

Waise, T. M. Zaved, Dranse, Helen J., Lam, Tony K. T.·2018·Nature Reviews Gastroenterology & Hepatology

Abstract

The regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in gastrointestinal regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity.

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Crossref · 10.1038/s41575-018-0062-1

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251 of 251 references verified0 citation errors · 0 not checkable

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  • Sensory afferent neurons of the vagus nerve detect a diverse range of chemical and mechanical stimuli within the intestines and GMB, and transmit messages to the nucleus tractus solitarius in the brainstem to initiate autonomic, endocrine and behavioural responses.

    “In turn, sensory afferent neurons of the vagus nerve detect a diverse range of chemical and mechanical stimuli within the intestines and GMB, and transmit messages to the nucleus tractus solitarius in the brainstem to initiate autonomic, endocrine and behavioural responses104.”

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Authors
Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T.
Affiliations
University Health Network (CA)
Corresponding author
Lam, Tony K. T.
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2018-09-05
Volume
15
Issue
10
Pages
625-636
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W2890943375
Cited by
140
References
251
Citations by year
2026: 21 · 2025: 25 · 2024: 22 · 2023: 16 · 2022: 16 · 2021: 24 · 2020: 10 · 2019: 6
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
vagus nerve, gut-brain signaling, glucose homeostasis, energy homeostasis, appetite regulation, obesity, diabetes mellitus
MeSH terms
Animals, Energy Metabolism, Glucose, Homeostasis, Humans, Vagus Nerve, Gastrointestinal Tract

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