Turnbull, Douglass M.

Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA

Andrews, R. M., Kubacka, I., Chinnery, P. F., Lightowlers, R. N., Turnbull, D. M., & Howell, N. (1999) · Nature Genetics

Forensic and Genetic ResearchGenomics and Phylogenetic Studies

Cited by 3,337

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics

Mitochondrial Function and PathologyParkinson's Disease Mechanisms and Treatments

Cited by 1,570

Mitochondrial DNA mutations and human disease

Tuppen, H. A. L., Blakely, E. L., Turnbull, D. M., & Taylor, R. W. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 676

Mitochondrial DNA mutations in human colonic crypt stem cells

Taylor, R. W., Barron, M. J., Borthwick, G. M., Gospel, A., Chinnery, P. F., Samuels, D. C., Taylor, G. A., Plusa, S. M., Needham, S. J., Greaves, L. C., et al. (2003) · Journal of Clinical Investigation

Mitochondrial Function and PathologyForensic and Genetic Research

Cited by 530

Mitochondrial changes within axons in multiple sclerosis

Mahad, D. J., Ziabreva, I., Campbell, G., Lax, N., White, K., Hanson, P. S., Lassmann, H., & Turnbull, D. M. (2009) · Brain

Multiple Sclerosis Research StudiesMitochondrial Function and Pathology

Cited by 454

Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance

Hudson, G., Amati-Bonneau, P., Blakely, E. L., Stewart, J. D., He, L., Schaefer, A. M., Griffiths, P. G., Ahlqvist, K., Suomalainen, A., Reynier, P., et al. (2008) · Brain

Mitochondrial Function and PathologyHereditary Neurological Disorders

Cited by 428

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age

Elson, J. L., Samuels, D. C., Turnbull, D. M., & Chinnery, P. F. (2001) · The American Journal of Human Genetics

Mitochondrial Function and PathologyEvolution and Genetic Dynamics

Cited by 340

Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids

Taylor, R. W., Chinnery, P. F., Turnbull, D. M., & Lightowlers, R. N. (1997) · Nature Genetics

Mitochondrial Function and PathologyDNA and Nucleic Acid Chemistry

Cited by 249

Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia

Longley, M. J., Clark, S., Yu Wai Man, C., Hudson, G., Durham, S. E., Taylor, R. W., Nightingale, S., Turnbull, D. M., Copeland, W. C., & Chinnery, P. F. (2006) · The American Journal of Human Genetics

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 248

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

McDonald, S. A. C., Greaves, L. C., Gutierrez–Gonzalez, L., Rodriguez–Justo, M., Deheragoda, M., Leedham, S. J., Taylor, R. W., Lee, C. Y., Preston, S. L., Lovell, M., et al. (2008) · Gastroenterology

Gastric Cancer Management and OutcomesCancer Cells and Metastasis

Cited by 242

Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions

Taivassalo, T., Gardner, J. L., Taylor, R. W., Schaefer, A. M., Newman, J., Barron, M. J., Haller, R. G., & Turnbull, D. M. (2006) · Brain

Mitochondrial Function and PathologyCardiovascular and exercise physiology

Cited by 220

Random genetic drift determines the level of mutant mtDNA in human primary oocytes

Brown, D. T., Samuels, D. C., Michael, E. M., Turnbull, D. M., & Chinnery, P. F. (2001) · The American Journal of Human Genetics

Mitochondrial Function and PathologyForensic and Genetic Research

Cited by 196

Review: Mitochondria and disease progression in multiple sclerosis

Mahad, D., Lassmann, H., & Turnbull, D. (2008) · Neuropathology and Applied Neurobiology

Multiple Sclerosis Research StudiesMitochondrial Function and Pathology

Cited by 193

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing

Greaves, L. C., Nooteboom, M., Elson, J. L., Tuppen, H. A. L., Taylor, G. A., Commane, D. M., Arasaradnam, R. P., Khrapko, K., Taylor, R. W., Kirkwood, T. B. L., et al. (2014) · PLoS Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 172

Analysis of European mtDNAs for Recombination

Elson, J. L., Andrews, R. M., Chinnery, P. F., Lightowlers, R. N., Turnbull, D. M., & Howell, N. (2001) · The American Journal of Human Genetics

Forensic and Genetic ResearchGenetic diversity and population structure

Cited by 142

Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons

Whittaker, R. G., Turnbull, D. M., Whittington, M. A., & Cunningham, M. O. (2011) · Brain

Neural dynamics and brain functionNeuroscience and Neuropharmacology Research

Cited by 74

A homoplasmic mtDNA variant can influence the phenotype of the pathogenic m.7472Cins MTTS1 mutation: are two mutations better than one?

Swalwell, H., Blakely, E. L., Sutton, R., Tonska, K., Elstner, M., He, L., Taivassalo, T., Burns, D. K., Turnbull, D. M., Haller, R. G., et al. (2008) · European Journal of Human Genetics

Mitochondrial Function and PathologyGenomics and Rare Diseases

Cited by 34

A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits

Craig, K., Young, M. J., Blakely, E. L., Longley, M. J., Turnbull, D. M., Copeland, W. C., & Taylor, R. W. (2012) · Mitochondrion

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 24

Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?

Brown, A. E., Elstner, M., Yeaman, S. J., Turnbull, D. M., & Walker, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 8