Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age

Mitochondrial diseases in man and mouse

Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,256 · see citing works

MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059 · see citing works

Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria

Bereiter‐Hahn, J., & Vöth, M. (1994) · Microscopy Research and Technique · doi:10.1002/jemt.1070270303 · Cited by 900 · see citing works

Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder

Nishino, I., Spinazzola, A., & Hirano, M. (1999) · Science · doi:10.1126/science.283.5402.689 · Cited by 899 · see citing works

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng1292-324 · Cited by 890 · see citing works

Detection of a specific mitochondrial DNA deletion in tissues of older humans

Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 785 · see citing works

Role of Adenine Nucleotide Translocator 1 in mtDNA Maintenance

Kaukonen, J., Juselius, J. K., Tiranti, V., Kyttälä, A., Zeviani, M., Comi, G. P., Keränen, S., Peltonen, L., & Suomalainen, A. (2000) · Science · doi:10.1126/science.289.5480.782 · Cited by 636 · see citing works

A Direct Repeat Is a Hotspot for Large-Scale Deletion of Human Mitochondrial DNA

Schon, E. A., Rizzuto, R., Moraes, C. T., Nakase, H., Zeviani, M., & DiMauro, S. (1989) · Science · doi:10.1126/science.2711184 · Cited by 569 · see citing works

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

Hayashi, J., Ohta, S., Kikuchi, A., Takemitsu, M., Goto, Y., & Nonaka, I. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10614 · Cited by 552 · see citing works

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

Lightowlers, R. N., Chinnery, P. F., Turnbull, D. M., & Howell, N. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01266-3 · Cited by 471 · see citing works

Mitochondrial DNA Mutations and Pathogenesis

Schon, E. A., Bonilla, E., & DiMauro, S. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022685929755 · Cited by 421 · see citing works

Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat

Gross, N. J., Getz, G. S., & Rabinowitz, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91795-3 · Cited by 379 · see citing works

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

Corral‐Debrinski, M., Shoffner, J. M., Lott, M. T., & Wallace, D. C. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90021-g · Cited by 360 · see citing works

Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle

Bogenhagen, D. F., & Clayton, D. A. (1977) · Cell · doi:10.1016/0092-8674(77)90286-0 · Cited by 312 · see citing works

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

Yoneda, M., Chomyn, A., Martinuzzi, A., Hurko, O., & Attardi, G. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11164 · Cited by 291 · see citing works

High Direct Estimate of the Mutation Rate in the Mitochondrial Genome of Caenorhabditis elegans

Denver, D. R., Morris, K., Lynch, M., Vassilieva, L. L., & Thomas, W. K. (2000) · Science · doi:10.1126/science.289.5488.2342 · Cited by 289 · see citing works

A proposed refinement of the mitochondrial free radical theory of aging

de Grey, A. D. N. J. (1997) · BioEssays · doi:10.1002/bies.950190211 · Cited by 288 · see citing works

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

Müller‐Höcker, J. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90006-9 · Cited by 284 · see citing works

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

Brierley, E. J., Johnson, M. A., Lightowlers, R. N., James, O., & Turnbull, D. M. (1998) · Annals of Neurology · doi:10.1002/ana.410430212 · Cited by 282 · see citing works

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

Melov, S., Shoffner, J. M., Kaufman, A. E., & Wallace, D. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.20.4122 · Cited by 271 · see citing works

In situ localization of mitochondrial DNA replication in intact mammalian cells.

Davis, A. F., & Clayton, D. A. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.4.883 · Cited by 256 · see citing works

Relaxed Replication of mtDNA: A Model with Implications for the Expression of Disease

Chinnery, P. F., & Samuels, D. C. (1999) · The American Journal of Human Genetics · doi:10.1086/302311 · Cited by 200 · see citing works

A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle.

Weber, K., Wilson, J., Taylor, L., Brierley, E. J., Johnson, M. A., Turnbull, D. M., & Bindoff, L. A. (1997) · PubMed · Cited by 199 · see citing works

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing

Liu, V. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1268 · Cited by 168 · see citing works

Polymyositis with cytochrome oxidase negative muscle fibres. Early quadriceps weakness and poor response to immunosuppressive therapy

Blume, G. (1997) · Brain · doi:10.1093/brain/120.1.39 · Cited by 108 · see citing works

Mitochondrial DNA and RNA processing in MELAS

Kaufmann, P., Shanske, S., Hirano, M., DiMauro, S., King, M. P., Koga, Y., & Schon, E. A. (1996) · Annals of Neurology · doi:10.1002/ana.410400208 · Cited by 75 · see citing works

Neuropathological and Histochemical Changes in a Multiple Mitochondrial DNA Deletion Disorder

Cottrell, D. A., Ince, P. G., Blakely, E. L., Johnson, M. A., Chinnery, P. F., Hanna, M. G., & Turnbull, D. M. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.7.621 · Cited by 45 · see citing works

The mutation rate of the human mtDNA deletion mtDNA4977.

Shenkar, R., Navidi, W. C., Tavaré, S., Dang, M. H., Chomyn, A., Attardi, G. M., Cortopassi, G. A., & Arnheim, N. (1996) · PubMed Central · Cited by 41 · see citing works

Induction of a Particular Deletion in Mitochondrial DNA by X Rays Depends on the Inherent Radiosensitivity of the Cells

Kubota, N., Hayashi, J., Inada, T., & Iwamura, Y. (1997) · Radiation Research · doi:10.2307/3579525 · Cited by 41 · see citing works

Mitochondrial DNA mutations in human disease

Taylor, R. W., & Turnbull, D. M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1606 · Cited by 1,866 · see citing works

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

Stewart, J. B., & Chinnery, P. F. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3966 · Cited by 1,041 · see citing works

Mitochondrial fragmentation in neurodegeneration.

Knott, A. B., Perkins, G., Schwarzenbacher, R., & Bossy-Wetzel, E. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2417 · Cited by 1,002 · see citing works

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

Reeve, A. K., Simcox, E. M., & Turnbull, D. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.01.004 · Cited by 961 · see citing works

A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease

Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758 · see citing works

Mitochondrial DNA mutations and human disease

Tuppen, H. A. L., Blakely, E. L., Turnbull, D. M., & Taylor, R. W. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.005 · Cited by 676 · see citing works

Mammalian Mitochondria and Aging: An Update

Kauppila, T. E. S., Kauppila, J. H. K., & Larsson, N.-G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.017 · Cited by 578 · see citing works

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

Ludwig, L. S., Lareau, C. A., Ulirsch, J. C., Christian, E., Muus, C., Li, L. H., Pelka, K., Ge, W. H., Oren, Y., Brack, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.022 · Cited by 534 · see citing works

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Larsson, N. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060408-093701 · Cited by 543 · see citing works

Mitochondrial DNA mutations in human colonic crypt stem cells

Taylor, R. W., Barron, M. J., Borthwick, G. M., Gospel, A., Chinnery, P. F., Samuels, D. C., Taylor, G. A., Plusa, S. M., Needham, S. J., Greaves, L. C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19435 · Cited by 530 · see citing works

Mitochondrial point mutations do not limit the natural lifespan of mice

Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics · doi:10.1038/ng1988 · Cited by 404 · see citing works

Universal heteroplasmy of human mitochondrial DNA

Payne, B. A. I., Wilson, I., Yu‐Wai‐Man, P., Coxhead, J., Deehan, D. J., Horváth, R., Taylor, R. W., Samuels, D. C., Santibanez‐Koref, M., & Chinnery, P. F. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds435 · Cited by 396 · see citing works

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

Picca, A., Mankowski, R. T., Burman, J. L., Donisi, L., Js, K., Marzetti, E., & Leeuwenburgh, C. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0059-z · Cited by 393 · see citing works

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Campbell, G. R., Ziabreva, I., Reeve, A. K., Krishnan, K. J., Reynolds, R., Howell, O., Lassmann, H., Turnbull, D. M., & Mahad, D. (2011) · Annals of Neurology · doi:10.1002/ana.22109 · Cited by 379 · see citing works

What causes mitochondrial DNA deletions in human cells?

Krishnan, K. J., Reeve, A. K., Samuels, D. C., Chinnery, P. F., Blackwood, J. K., Taylor, R. W., Wanrooij, S., Spelbrink, J. N., Lightowlers, R. N., & Turnbull, D. M. (2008) · Nature Genetics · doi:10.1038/ng.f.94 · Cited by 380 · see citing works

Mitochondrial function in hypoxic ischemic injury and influence of aging

Ham, P. B., & Raju, R. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.006 · Cited by 367 · see citing works

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335 · see citing works

Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR

He, L. (2002) · Nucleic Acids Research · doi:10.1093/nar/gnf067 · Cited by 320 · see citing works

Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals

Ye, K., Lü, J., Ma, F., Keinan, A., & Gu, Z. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403521111 · Cited by 296 · see citing works

Recent Advances in Mitochondrial Disease

Craven, L., Alston, C. L., Taylor, R. W., & Turnbull, D. M. (2017) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091416-035426 · Cited by 290 · see citing works

MtDNA mutations in aging and apoptosis

Chomyn, A., & Attardi, G. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00625-9 · Cited by 243 · see citing works

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

McDonald, S. A. C., Greaves, L. C., Gutierrez–Gonzalez, L., Rodriguez–Justo, M., Deheragoda, M., Leedham, S. J., Taylor, R. W., Lee, C. Y., Preston, S. L., Lovell, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.035 · Cited by 242 · see citing works

Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?

Chinnery, P. F., Samuels, D. C., Elson, J. L., & Turnbull, D. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11310-9 · Cited by 234 · see citing works

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

Payne, B. A. I., Wilson, I., Hateley, C. A., Horváth, R., Santibanez‐Koref, M., Samuels, D. C., Price, D., & Chinnery, P. F. (2011) · Nature Genetics · doi:10.1038/ng.863 · Cited by 232 · see citing works

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

Nekhaeva, E., Bodyak, N. D., Kraytsberg, Y., McGrath, S., van Orsouw, N. J., Pluzhnikov, A., Wei, J. Y., Vijg, J., & Khrapko, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072670199 · Cited by 205 · see citing works

Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

Herbst, A., Pak, J. W., McKenzie, D., Bua, E., Bassiouni, M., & Aiken, J. M. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.3.235 · Cited by 200 · see citing works

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

Fukui, H., & Moraes, C. T. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn437 · Cited by 185 · see citing works

The Role of Mitochondrial DNA Mutations in Mammalian Aging

Kujoth, G. C., Bradshaw, P. C., Haroon, S., & Prolla, T. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030024 · Cited by 186 · see citing works

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

Stewart, J. B., Freyer, C., Elson, J. L., & Larsson, N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2396 · Cited by 184 · see citing works

Mechanisms linking mtDNA damage and aging

Pinto, M., & Moraes, C. T. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.005 · Cited by 179 · see citing works

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180 · see citing works

The rise and rise of mitochondrial DNA mutations

Lawless, C., Greaves, L. C., Reeve, A. K., Turnbull, D. M., & Vincent, A. E. (2020) · Open Biology · doi:10.1098/rsob.200061 · Cited by 174 · see citing works

Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control

Díaz, F. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf602 · Cited by 171 · see citing works

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing

Greaves, L. C., Nooteboom, M., Elson, J. L., Tuppen, H. A. L., Taylor, G. A., Commane, D. M., Arasaradnam, R. P., Khrapko, K., Taylor, R. W., Kirkwood, T. B. L., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004620 · Cited by 172 · see citing works

Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges

Spelbrink, J. N. (2010) · IUBMB Life · doi:10.1002/iub.282 · Cited by 171 · see citing works

Morpho-dynamic changes of mitochondria during ageing of human endothelial cells

Jendrach, M., Pohl, S., Vöth, M., Kowald, A., Hammerstein, P., & Bereiter‐Hahn, J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.002 · Cited by 170 · see citing works

Signaling networks determining life span

Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161 · see citing works

Mitochondrial DNA mutations in neurodegeneration

Keogh, M. J., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.015 · Cited by 163 · see citing works

How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue

Birch-Machin, M. A., & Swalwell, H. (2010) · Mutagenesis · doi:10.1093/mutage/gep061 · Cited by 159 · see citing works

Locating the stem cell niche and tracing hepatocyte lineages in human liver #

Fellous, T. G., Islam, S., Tadrous, P. J., Elia, G., Kocher, H. M., Bhattacharya, S., Mears, L., Turnbull, D. M., Taylor, R. W., Greaves, L. C., et al. (2009) · Hepatology · doi:10.1002/hep.22791 · Cited by 157 · see citing works

Systems biology of ageing and longevity

Kirkwood, T. B. L. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0275 · Cited by 156 · see citing works

The 4977bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?

Meißner, C., Bruse, P., Mohamed, S. A., Schulz, A., Warnk, H., Storm, T., & Oehmichen, M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.004 · Cited by 154 · see citing works

Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration

Reeve, A. K., Krishnan, K. J., & Turnbull, D. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.016 · Cited by 146 · see citing works

Clonal dynamics in early human embryogenesis inferred from somatic mutation

Park, S., Mali, N. M., Kim, R., Choi, J., Lee, J., Lim, J., Park, J. M., Park, J. W., Kim, D., Kim, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03786-8 · Cited by 142 · see citing works

Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans

Samuels, D. C., Li, C., Li, B., Song, Z., Torstenson, E. S., Clay, H. B., Rokas, A., Thornton‐Wells, T. A., Moore, J. H., Hughes, T. M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003929 · Cited by 139 · see citing works

Mitochondrial DNA in human identification: a review

Amorim, A., Fernandes, T. M., & Taveira, N. (2019) · PeerJ · doi:10.7717/peerj.7314 · Cited by 129 · see citing works

Molecular pathology and age estimation

Meißner, C., & Ritz‐Timme, S. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.07.010 · Cited by 131 · see citing works

Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

Wei, W., Keogh, M. J., Wilson, I., Coxhead, J. M., Ryan, S., Rollinson, S. J., Griffin, H. R., Kurzawa‐Akanbi, M., Santibanez‐Koref, M., Talbot, K., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0404-6 · Cited by 128 · see citing works

Evolution of the mitochondrial fusion–fission cycle and its role in aging

Kowald, A., & Kirkwood, T. B. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101604108 · Cited by 126 · see citing works

Mitochondrial DNA: Impacting Central and Peripheral Nervous Systems

Carelli, V., & Chan, D. C. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.022 · Cited by 127 · see citing works

The free‐radical theory of ageing – older, wiser and still alive

Kirkwood, T. B. L., & Kowald, A. (2012) · BioEssays · doi:10.1002/bies.201200014 · Cited by 125 · see citing works

Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

TEIXEIRA, V. H., Nadarajan, P., Graham, T. A., Pipinikas, C., Brown, J., Falzon, M., Nye, E. L., Poulsom, R., Lawrence, D. R., Wright, N. A., et al. (2013) · eLife · doi:10.7554/elife.00966 · Cited by 124 · see citing works

The mitochondrial theory of aging: dead or alive?

Jacobs, H. T. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00032.x · Cited by 117 · see citing works

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

Napoli, E., Ross‐Inta, C., Wong, S., Hung, C., Fujisawa, Y., Sakaguchi, D., Angelastro, J. M., Omanska-Klusek, A., Schoenfeld, R. A., & Giulivi, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042504 · Cited by 116 · see citing works

Mitochondrial DNA mutations and aging: devils in the details?

Khrapko, K., & Vijg, J. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.11.007 · Cited by 112 · see citing works

Mitophagy plays a central role in mitochondrial ageing

Diot, A., Morten, K., & Poulton, J. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9651-x · Cited by 109 · see citing works

Exercise and training in mitochondrial myopathies

TAIVASSALO, T., & HALLER, R. G. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000177446.97671.2a · Cited by 106 · see citing works

Mitochondrial and inflammatory changes in sporadic inclusion body myositis

Rygiel, K. A., Miller, J. A. L., Grady, J. P., Rocha, M. C., Taylor, R. W., & Turnbull, D. M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12149 · Cited by 105 · see citing works

Molecular mechanisms of cardiomyocyte aging

Sheydina, A., Riordon, D. R., & Boheler, K. R. (2011) · Clinical Science · doi:10.1042/cs20110115 · Cited by 101 · see citing works

the Histogenesis of Regenerative Nodules in Human Liver Cirrhosis

Lin, W., Lim, S., McDonald, S. A. C., Graham, T. A., Wright, V. L., Peplow, C. L., Humphries, A., Kocher, H. M., Wright, N. A., Dhillon, A. P., et al. (2009) · Hepatology · doi:10.1002/hep.23483 · Cited by 99 · see citing works

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

Johnston, I. G., Burgstaller, J. P., Havlíček, V., Kolbe, T., Rülicke, T., Brem, G., Poulton, J., & Jones, N. S. (2015) · eLife · doi:10.7554/elife.07464 · Cited by 91 · see citing works

Aging: A mitochondrial DNA perspective, critical analysis and an update

Shokolenko, I. N. (2014) · World Journal of Experimental Medicine · doi:10.5493/wjem.v4.i4.46 · Cited by 99 · see citing works

Somatic mutations of mitochondrial DNA in aging and cancer progression

Lee, H., Chang, C., & Chi, C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.009 · Cited by 93 · see citing works

The ageing mitochondrial genome

Krishnan, K. J., Greaves, L. C., Reeve, A. K., & Turnbull, D. M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm635 · Cited by 89 · see citing works

Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?

Busch, K. B., Kowald, A., & Spelbrink, J. N. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0442 · Cited by 87 · see citing works

Mitochondrial DNA mutations in human disease

Greaves, L. C., & Taylor, R. W. (2006) · IUBMB Life · doi:10.1080/15216540600686888 · Cited by 88 · see citing works

Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor

Nicholson, A. M., Graham, T. A., Simpson, A. I., Humphries, A., Burch, N., Rodriguez‐Justo, M., Novelli, M. R., Harrison, R. F., Wright, N. A., McDonald, S. A. C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301174 · Cited by 84 · see citing works

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Ahier, A., Dai, C.-Y., Tweedie, A., Bezawork‐Geleta, A., Kirmes, I., & Zuryn, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0023-x · Cited by 79 · see citing works

Bayesian Emulation and Calibration of a Stochastic Computer Model of Mitochondrial DNA Deletions in Substantia Nigra Neurons

Henderson, D. A., Boys, R. J., Krishnan, K. J., Lawless, C., & Wilkinson, D. J. (2009) · Journal of the American Statistical Association · doi:10.1198/jasa.2009.0005 · Cited by 84 · see citing works

A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues

Fellous, T. G., McDonald, S. A. C., Burkert, J., Humphries, A., Islam, S., De-Alwis, N. M. W., Gutiérrez-González, L., Tadrous, P. J., Elia, G., Kocher, H. M., et al. (2009) · Stem Cells · doi:10.1002/stem.67 · Cited by 80 · see citing works

Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging

Pak, J. W., Herbst, A. J., Bua, E. A., Gokey, N. G., McKenzie, D. I., & Aiken, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00034.x · Cited by 83 · see citing works

Subcellular origin of mitochondrial DNA deletions in human skeletal muscle

Vincent, A. E., Rosa, H. S., Pabis, K., Lawless, C., Chen, C., Grünewald, A., Rygiel, K. A., Rocha, M. C., Reeve, A. K., Falkous, G., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25288 · Cited by 82 · see citing works

High-frequency and functional mitochondrial DNA mutations at the single-cell level

Guo, X., Xu, W., Zhang, W., Pan, C., Thalacker‐Mercer, A. E., Zheng, H., & Gu, Z. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201518120 · Cited by 85 · see citing works

The mitochondrial genome in aging and senescence

Lauri, A., Pompilio, G., & Capogrossi, M. C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.001 · Cited by 80 · see citing works

Somatic mitochondrial DNA mutations in single neurons and glia

Cantuti‐Castelvetri, I., Lin, M. T. S., Zheng, K., Keller-McGandy, C. E., Betensky, R. A., Johns, D. R., Beal, M. F., Standaert, D. G., & Simon, D. K. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.11.008 · Cited by 81 · see citing works

Mitochondrial DNA Mutations and Aging

Krishnan, K. J., Greaves, L. C., Reeve, A. K., & Turnbull, D. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.024 · Cited by 79 · see citing works

Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality

Tranah, G. J., Katzman, S. M., Lauterjung, K., Yaffe, K. S., Manini, T. M., Kritchevsky, S. B., Newman, A. B., Harris, T. B., & Cummings, S. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-30255-6 · Cited by 78 · see citing works

Review: Mitochondrial medicine--cardiomyopathy caused by defective oxidative phosphorylation.

Fosslien, E. (2003) · PubMed · Cited by 77 · see citing works

Mitochondrial function and mitochondrial DNA maintenance with advancing age

Gaziev, A. I., Abdullaev, S., & Podlutsky, A. (2014) · Biogerontology · doi:10.1007/s10522-014-9515-2 · Cited by 77 · see citing works

The Cellular Mitochondrial Genome Landscape in Disease

Hahn, A., & Zuryn, S. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.11.004 · Cited by 75 · see citing works

Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing

Otten, A. B. C., & Smeets, H. J. M. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv024 · Cited by 77 · see citing works

Recent Advances in Detecting Mitochondrial DNA Heteroplasmic Variations

Duan, M., Tu, J., & Lu, Z. (2018) · Molecules · doi:10.3390/molecules23020323 · Cited by 74 · see citing works

Somatic mitochondrial DNA mutations in adult-onset leukaemia

He, L., Luo, L., Proctor, S. J., Middleton, P. G., Blakely, E. L., Taylor, R. W., & Turnbull, D. M. (2003) · Leukemia · doi:10.1038/sj.leu.2403146 · Cited by 76 · see citing works

Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction

Murphy, M. P. (2001) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.1.5.753 · Cited by 76 · see citing works

Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing

Drake, J. C., & Yan, Z. (2017) · The Journal of Physiology · doi:10.1113/jp274337 · Cited by 74 · see citing works

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Kauppila, J. H. K., Bonekamp, N. A., Mourier, A., Isokallio, M. A., Just, A., Kauppila, T. E. S., Stewart, J. B., & Larsson, N. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky456 · Cited by 77 · see citing works

Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans

Guo, Y. P., Li, C.-I., Sheng, Q., Winther, J. F., Cai, Q., Boice, J. D., & Shyr, Y. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.10.003 · Cited by 74 · see citing works

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

Kowald, A., & Kirkwood, T. B. L. (2018) · Genes · doi:10.3390/genes9030126 · Cited by 72 · see citing works

Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations

Carelli, V., Maresca, A., Caporali, L., Trifunov, S., Zanna, C., & Rugolo, M. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.01.023 · Cited by 72 · see citing works

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Greaves, L. C., Elson, J. L., Nooteboom, M., Grady, J. P., Taylor, G. A., Taylor, R. W., Mathers, J. C., Kirkwood, T. B. L., & Turnbull, D. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003082 · Cited by 72 · see citing works

Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

Tam, Z. Y., Gruber, J., Halliwell, B. B., & Gunawan, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076230 · Cited by 71 · see citing works

Changes in Mitochondrial DNA Deletion, Content, and Biogenesis in Folate-Deficient Tissues of Young Rats Depend on Mitochondrial Folate and Oxidative DNA Injuries3

Chou, Y.-F., Yu, C.-C., & Huang, R.-F. S. (2007) · Journal of Nutrition · doi:10.1093/jn/137.9.2036 · Cited by 71 · see citing works

Mitochondrial DNA clonality in the dock: can surveillance swing the case?

Elson, J. L., & Lightowlers, R. N. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.09.004 · Cited by 70 · see citing works

Identifying functional links between genes using conserved chromosomal proximity

Yanai, I., Mellor, J. C., & DeLisi, C. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02621-x · Cited by 70 · see citing works

The human urothelium consists of multiple clonal units, each maintained by a stem cell

Gaisa, N. T., Graham, T. A., McDonald, S. A. C., Cañadillas, S., Poulsom, R., Heidenreich, A., Jakse, G., Tadrous, P. J., Knuechel, R., & Wright, N. A. (2011) · The Journal of Pathology · doi:10.1002/path.2945 · Cited by 68 · see citing works

Mitochondrial Abnormality Associates with Type-Specific Neuronal Loss and Cell Morphology Changes in the Pedunculopontine Nucleus in Parkinson Disease

Pienaar, I. S., Elson, J. L., Racca, C., Nelson, G., Turnbull, D. M., & Morris, C. M. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.002 · Cited by 69 · see citing works

Origins of mtDNA mutations in ageing

Szczepanowska, K., & Trifunović, A. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160090 · Cited by 70 · see citing works

Mitochondria and ageing: winning and losing in the numbers game

Passos, J. F., von Zglinicki, T., & Kirkwood, T. B. L. (2007) · BioEssays · doi:10.1002/bies.20634 · Cited by 66 · see citing works

Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

Burgstaller, J. P., Kolbe, T., Havlíček, V., Hembach, S., Poulton, J., Piálek, J., Steinborn, R., Rülicke, T., Brem, G., Jones, N. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04797-2 · Cited by 66 · see citing works

Frequent Intracellular Clonal Expansions of Somatic mtDNA Mutations

Coller, H. A., Bodyak, N. D., & Khrapko, K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02113.x · Cited by 59 · see citing works

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction

Ageing, D. H., Greaves, L. C., Nooteboom, M., Elson, J. L., Taylor, G. A., Commane, D. M., Arasaradnam, R. P., Khrapko, K., Taylor, R. W., Kirkwood, T. B. L., et al. (2016)

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing

Greaves, L. C., Nooteboom, M., Elson, J. L., Tuppen, H. A. L., Taylor, G. A., Commane, D. M., Arasaradnam, R. P., Khrapko, K., Taylor, R. W., Kirkwood, T. B. L., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004620 · Cited by 172 · see citing works

The rise and rise of mitochondrial DNA mutations

Lawless, C., Greaves, L. C., Reeve, A. K., Turnbull, D. M., & Vincent, A. E. (2020) · Open Biology · doi:10.1098/rsob.200061 · Cited by 174 · see citing works

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Baines, H. L., Stewart, J. B., Stamp, C., Županič, A., Kirkwood, T. B. L., Larsson, N., Turnbull, D. M., & Greaves, L. C. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.06.003 · Cited by 41 · see citing works