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Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway

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The mitochondrial free radical theory of ageing - Where do we stand?

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The diversity and commonalities of gastroenteropancreatic neuroendocrine tumors

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The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility

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Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response

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The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol

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How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue

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An integrative computational model for intestinal tissue renewal

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Locating the stem cell niche and tracing hepatocyte lineages in human liver #

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Stem cells and their implications for colorectal cancer

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Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

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Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement

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Origins of human mitochondrial point mutations as DNA polymerase γ-mediated errors

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Aging of the mammalian gastrointestinal tract: a complex organ system

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A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

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Selection against Pathogenic mtDNA Mutations in a Stem Cell Population Leads to the Loss of the 3243A→G Mutation in Blood

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Wnt Signaling, Stem Cells, and Cancer of the Gastrointestinal TractPreprint

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Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis

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Mitochondria, telomeres and cell senescence

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Metabolic alterations in cancer cells and therapeutic implications

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Molecular pathology and age estimation

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Mitochondrial function and gastrointestinal diseases

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Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

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A hybrid approach to multi-scale modelling of cancer

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The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization

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Mitochondrial Heterogeneity

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Intestinal stem cells

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Aging as a catabolic malfunction

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Keeping mtDNA in Shape between Generations

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Intestinal Epithelial Stem Cells and Progenitors

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Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes

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Mitochondrial DNA mutations and aging in human colonic crypts and stem cells

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Age‐associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

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Summary

Take, S., Nooteboom, M., Johnson, R., Taylor, R. W., Wright, N. A., Lightowlers, R. N., Kirkwood, T. B. L., Mathers, J. C., Turnbull, D. M., & Greaves, L. C. (2009)

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

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Tales from the crypt

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