Perlman, Stanley

Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology

Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 2,524

Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2

Netland, J., Meyerholz, D. K., Moore, S., Cassell, M., & Perlman, S. (2008) · Journal of Virology

SARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19

Cited by 1,293

Lethal Infection of K18- hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus

McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., et al. (2007) · Journal of Virology

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 1,010

Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

Liu, L., Wei, Q., Lin, Q., Fang, J., Wang, H., Kwok, H., Tang, H., Nishiura, K., Peng, J., Tan, Z., et al. (2019) · JCI Insight

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 830

Animal models for COVID-19

Muñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P.-S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 798

T cell-mediated immune response to respiratory coronaviruses

Channappanavar, R., Zhao, J., & Perlman, S. (2014) · Immunologic Research

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 512

Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

Zhao, J., Zhao, J., Mangalam, A. K., Channappanavar, R., Fett, C., Meyerholz, D. K., Agnihothram, S., Baric, R. S., David, C. S., & Perlman, S. (2016) · Immunity

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 496

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

Li, K., Wohlford-Lenane, C., Perlman, S., Zhao, J., Jewell, A. K., Reznikov, L. R., Gibson-Corley, K. N., Meyerholz, D. K., & McCray, P. B. (2016) · Journal of Infectious Diseases

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 459

Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection

Channappanavar, R., Fett, C., Zhao, J., Meyerholz, D. K., & Perlman, S. (2014) · Journal of Virology

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 411

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

Zhao, J., Zhao, J., & Perlman, S. (2010) · Journal of Virology

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 340

Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons

Pettit, D. L., Perlman, S., & Malinow, R. (1994) · Science

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 329

Lessons for COVID-19 immunity from other coronavirus infections

Sariol, A., & Perlman, S. (2020) · Immunity

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 317

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

Zhao, J., Zhao, J., Legge, K., & Perlman, S. (2011) · Journal of Clinical Investigation

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 265

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

Corti, D., Zhao, J., Pedotti, M., Simonelli, L., Agnihothram, S., Fett, C., Fernandez-Rodriguez, B., Foglierini, M., Agatic, G., Vanzetta, F., et al. (2015) · Proceedings of the National Academy of Sciences

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 216

Microglia are required for protection against lethal coronavirus encephalitis in mice

Wheeler, D. L., Sariol, A., Meyerholz, D. K., & Perlman, S. (2018) · Journal of Clinical Investigation

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 212

CD4 and CD8 T Cells Have Redundant But Not Identical Roles in Virus-Induced Demyelination

Wu, G. F., Dandekar, A. A., Pewe, L., & Perlman, S. (2000) · The Journal of Immunology

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 192

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, S. A. J., Perlman, S., Cohen, M. S., Fehr, A. R., & Brenner, C. (2020) · Journal of Biological Chemistry

Sirtuins and Resveratrol in Medicineinterferon and immune responses

Cited by 192

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

Wong, L.-Y. R., Zheng, J., Wilhelmsen, K., Li, K., Ortiz, M. E., Schnicker, N. J., Thurman, A., Pezzulo, A. A., Szachowicz, P. J., Li, P., et al. (2022) · Nature

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 178

Consensus summary report for CEPI/BC March 12–13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines

Lambert, P.-H., Ambrosino, D. M., Andersen, S. R., Baric, R. S., Black, S. B., Chen, R. T., Dekker, C. L., Didierlaurent, A. M., Graham, B. S., Martin, S. D., et al. (2020) · Vaccine

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 119

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Sariol, A., Mackin, S., Allred, M.-G., Ma, C., Zhou, Y., Zhang, Q., Zou, X., Abrahante, J. E., Meyerholz, D. K., & Perlman, S. (2020) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 91

Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

Zhao, J., Perera, R. A. P. M., Kayali, G., Meyerholz, D., Perlman, S., & Peiris, M. (2015) · Journal of Virology

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 68

Depletion of Blood-Borne Macrophages Does Not Reduce Demyelination in Mice Infected with a Neurotropic Coronavirus

Xue, S., Sun, N., Van Rooijen, N., & Perlman, S. (1999) · Journal of Virology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 53

A research and development (R&D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy

Moore, K. A., Leighton, T., Ostrowsky, J. T., Anderson, C. J., Danila, R. N., Ulrich, A. K., Lackritz, E. M., Mehr, A. J., Baric, R. S., Baylor, N. W., et al. (2023) · Vaccine

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 25