Loomba, Rohit

Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2

Ganguly, S., Rosenthal, S. B., Ishizuka, K., Troutman, T. D., Rohm, T. V., Khader, N., Aleman-Muench, G., Sano, Y., Archilei, S., Soroosh, P., et al. (2024) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 145

Results from a new efficacy and safety analysis of the REGENERATE trial of obeticholic acid for treatment of pre-cirrhotic fibrosis due to non-alcoholic steatohepatitis

Sanyal, A. J., Ratziu, V., Loomba, R., Anstee, Q. M., Kowdley, K. V., Rinella, M. E., Sheikh, M. Y., Trotter, J. F., Knapple, W., Lawitz, E. J., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 137

Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease

Tamaki, N., Munaganuru, N., Jung, J., Yonan, A. Q., Loomba, R. R., Bettencourt, R., Ajmera, V., Valasek, M. A., Behling, C., Sirlin, C. B., et al. (2022) · Gut

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 130

Factors associated with histologic response in adult patients with nonalcoholic steatohepatitis

Loomba, R., Sanyal, A. J., Kowdley, K. V., Terrault, N., Chalasani, N. P., Abdelmalek, M. F., McCullough, A. J., Shringarpure, R., Ferguson, B., Lee, L., et al. (2019) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 124

Machine learning enables new insights into genetic contributions to liver fat accumulation

Haas, M. E., Pirruccello, J. P., Friedman, S. N., Wang, M., Emdin, C. A., Ajmera, V. H., Simon, T. G., Homburger, J. R., Guo, X., Budoff, M., et al. (2021) · Cell Genomics

Liver Disease Diagnosis and TreatmentGenetic Associations and Epidemiology

Cited by 118

Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease

Vuppalanchi, R., Jain, A. K., Deppe, R., Yates, K., Comerford, M., Masuoka, H. C., Neuschwander-Tetri, B. A., Loomba, R., Brunt, E. M., Kleiner, D. E., et al. (2014) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 116

Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis

Loomba, R., Huang, D. Q., Sanyal, A. J., Anstee, Q. M., Trauner, M., Lawitz, E. J., Ding, D., Ma, L., Jia, C., Billin, A., et al. (2023) · Gut

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 110

Safety, pharmacokinetics, and pharmacodynamics of pegozafermin in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 1b/2a multiple-ascending-dose study

Loomba, R., Lawitz, E. J., Frias, J. P., Ortiz-Lasanta, G., Johansson, L., Franey, B. B., Morrow, L., Rosenstock, M., Hartsfield, C. L., Chen, C.-Y., et al. (2023) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentFibroblast Growth Factor Research

Cited by 106

Alanine Aminotransferase Decreases with Age: The Rancho Bernardo Study

Dong, M. H., Bettencourt, R., Barrett-Connor, E., & Loomba, R. (2010) · PLoS ONE

Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

Cited by 103

A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis

Mak, L.-Y., Gane, E., Schwabe, C., Yoon, K. T., Heo, J., Scott, R., Lee, J.-H., Lee, J. I., Kweon, Y. O., Weltman, M., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentRNA Interference and Gene Delivery

Cited by 98

Exercise Training Is Associated With Treatment Response in Liver Fat Content by Magnetic Resonance Imaging Independent of Clinically Significant Body Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Stine, J. G., DiJoseph, K., Pattison, Z., Harrington, A., Chinchilli, V. M., Schmitz, K. H., & Loomba, R. (2023) · American Journal of Gastroenterology

Liver Disease Diagnosis and TreatmentPhysical Activity and Health

Cited by 94

Increases and decreases in liver stiffness measurement are independently associated with the risk of liver-related events in NAFLD

Gawrieh, S., Vilar-Gomez, E., Wilson, L. A., Pike, F., Kleiner, D. E., Neuschwander-Tetri, B. A., Diehl, A. M., Dasarathy, S., Kowdley, K. V., Hameed, B., et al. (2024) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 94

Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis

Maricic, I., Marrero, I., Eguchi, A., Nakamura, R., Johnson, C. D., Dasgupta, S., Hernandez, C. D., Nguyen, P. S., Swafford, A. D., Knight, R., et al. (2018) · The Journal of Immunology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 92

Systematic review with network meta-analysis: comparative efficacy of pharmacologic therapies for fibrosis improvement and resolution of NASH

Majzoub, A. M., Nayfeh, T., Barnard, A., Munaganuru, N., Dave, S., Singh, S., Murad, M. H., & Loomba, R. (2021) · Alimentary Pharmacology & Therapeutics

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 92

The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH

Loomba, R., Ling, L., Dinh, D. M., DePaoli, A. M., Lieu, H. D., Harrison, S. A., & Sanyal, A. J. (2021) · Hepatology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 88

Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study

Zarrinpar, A., Gupta, S., Maurya, M. R., Subramaniam, S., & Loomba, R. (2016) · Gut

Liver Disease Diagnosis and TreatmentMicroRNA in disease regulation

Cited by 88

Emerging role of genomic analysis in clinical evaluation of lean individuals with NAFLD

Vilarinho, S., Ajmera, V., Zheng, M., & Loomba, R. (2021) · Hepatology

Liver Disease Diagnosis and TreatmentGenetic Associations and Epidemiology

Cited by 85

Weight loss and weight regain in usual clinical practice: results from the TARGET-NASH observational cohort

Malespin, M. H., Barritt, A. S., Watkins, S. E., Schoen, C., Tincopa, M. A., Corbin, K. D., Mospan, A. R., Munoz, B., Trinh, H. N., Weiss, L. M., et al. (2022) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 75

Publisher Correction: The gut–liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 70

Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease

Tamaki, N., Ahlholm, N., Luukkonen, P. K., Porthan, K., Sharpton, S. R., Ajmera, V., Kono, Y., Dave, S., Ahmed, A., Sundaram, V., et al. (2022) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 69

Placebo effect on progression and regression in NASH: Evidence from a meta‐analysis

Ng, C. H., Xiao, J., Lim, W. H., Chin, Y. H., Yong, J. N., Tan, D. J. H., Tay, P., Syn, N., Foo, R., Chan, M., et al. (2022) · Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 69

Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach

Brennan, P. N., Elsharkawy, A. M., Kendall, T. J., Loomba, R., Mann, D. A., & Fallowfield, J. A. (2023) · Nature Reviews Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 68

Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients

Turner, A. M., Stolk, J., Bals, R., Lickliter, J. D., Hamilton, J., Christianson, D. R., Given, B. D., Burdon, J. G., Loomba, R., Stoller, J. K., et al. (2018) · Journal of Hepatology

RNA Interference and Gene DeliveryVirus-based gene therapy research

Cited by 67

NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH

Stine, J. G., Schreibman, I. R., Faust, A. J., Dahmus, J., Stern, B., Soriano, C., Rivas, G., Hummer, B., Kimball, S. R., Geyer, N. R., et al. (2022) · Hepatology

Liver Disease Diagnosis and TreatmentPhysical Activity and Health

Cited by 65