Calcineurin: a central controller of signalling in eukaryotes: Workshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566 · see citing works

Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy

Wilkins, B. J., Dai, Y., Bueno, O. F., Parsons, S. A., Xu, J., Plank, D. M., Jones, F. S., Kimball, T. R., & Molkentin, J. D. (2003) · Circulation Research · doi:10.1161/01.res.0000109415.17511.18 · Cited by 762 · see citing works

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Heissmeyer, V., Macián, F., Im, S., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y., Dustin, M. L., & Rao, A. (2004) · Nature Immunology · doi:10.1038/ni1047 · Cited by 515 · see citing works

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K. A., Tsien, R. W., & Crabtree, G. R. (1999) · Nature · doi:10.1038/44378 · Cited by 514 · see citing works

Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory

Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00585-2 · Cited by 498 · see citing works

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489 · see citing works

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

Malleret, G., Haditsch, U., Genoux, D., Jones, M. W., Bliss, T. V. P., Vanhoose, A. M., Weitlauf, C., Kandel, E. R., Winder, D. G., & Mansuy, I. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00264-1 · Cited by 470 · see citing works

Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a

Hernández, G., Volpert, O. V., Iñiguez, M. A., Lorenzo, E., Martı́nez-Martı́nez, S., Grau, R., Fresno, M., & Redondo, J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.607 · Cited by 428 · see citing works

Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

Graef, I. A., Chen, F., Chen, L., Kuo, A., & Crabtree, G. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00396-8 · Cited by 417 · see citing works

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

Winder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)80896-x · Cited by 350 · see citing works

Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis.

Chuvpilo, S., Jankevics, E., Tyrsin, D., Akimzhanov, A., Moroz, D., Jha, M., Schulze-Luehrmann, J., Santner‐Nanan, B., Feoktistova, E., König, T., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00329-1 · Cited by 216 · see citing works

Calcineurin Is Essential for <i>Candida albicans</i> Survival in Serum and Virulence

Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., Filler, S. G., Perfect, J. R., & Heitman, J. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.3.422-430.2003 · Cited by 186 · see citing works

GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNsPreprint

Hilioti, Z., Gallagher, D. A., Low-Nam, S. T., Ramaswamy, P., Gajer, P., Kingsbury, T. J., Birchwood, C. J., Levchenko, A., & Cunningham, K. W. (2003) · Genes & Development · doi:10.1101/gad.1159204 · Cited by 161 · see citing works

Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6

Kuhara, A., Inada, H., Katsura, I., & Mori, I. (2002) · Neuron · doi:10.1016/s0896-6273(02)00607-4 · Cited by 153 · see citing works

A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts

Neal, J. W., & Clipstone, N. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300528200 · Cited by 140 · see citing works

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

Ryeom, S. W., Greenwald, R. J., Sharpe, A. H., & McKeon, F. (2003) · Nature Immunology · doi:10.1038/ni966 · Cited by 128 · see citing works

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

Genescà, E., Aubareda, A., FUENTES, J. J., Estivill, X., de la Luna, S., & Pérez‐Riba, M. (2003) · Biochemical Journal · doi:10.1042/bj20030267 · Cited by 102 · see citing works

Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase IPreprint

Kafadar, K. A., Zhu, H., Snyder, M. P., & Cyert, M. (2003) · Genes & Development · doi:10.1101/gad.1140603 · Cited by 84 · see citing works

Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

Cribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,024 · see citing works

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

Faul, C., Donnelly, M., Merscher, S., Chang, Y. H., Franz, S., Delfgaauw, J., Chang, J., Choi, H. Y., Campbell, K. N., Kim, K., et al. (2008) · Nature Medicine · doi:10.1038/nm.1857 · Cited by 993 · see citing works

Calcium signalling in lymphocyte activation and disease

Feske, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2152 · Cited by 1,043 · see citing works

Specialized roles for cysteine cathepsins in health and disease

Reiser, J., Adair, B. D., & Reinheckel, T. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42918 · Cited by 582 · see citing works

Calcium–calcineurin signaling in the regulation of cardiac hypertrophy

Wilkins, B. J., & Molkentin, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.121 · Cited by 439 · see citing works

Sensing the environment: lessons from fungi

Bahn, Y., Xue, C., Idnurm, A., Rutherford, J. C., Heitman, J., & Cardenas, M. E. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1578 · Cited by 416 · see citing works

The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

Berchtold, M. W., & Villalobo, A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.10.021 · Cited by 312 · see citing works

Proteinuria: an enzymatic disease of the podocyte?

Mundel, P. H., & Reiser, J. (2009) · Kidney International · doi:10.1038/ki.2009.424 · Cited by 267 · see citing works

Calcineurin-Responsive Zinc Finger Transcription Factor CRZ1 of Botrytis cinerea Is Required for Growth, Development, and Full Virulence on Bean Plants

Schumacher, J., Fernandez-de-Larrinoa, Í., & Tudzynski, B. (2008) · Eukaryotic Cell · doi:10.1128/ec.00426-07 · Cited by 155 · see citing works

Inhibition of Calcineurin by FK506 Protects against Polyglutamine-Huntingtin Toxicity through an Increase of Huntingtin Phosphorylation at S421

Pardo, R., Colin, E., Régulier, E., Aebischer, P., Déglon, N., Humbert, S., & Saudou, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3706-05.2006 · Cited by 134 · see citing works

The podocyte as a direct target of immunosuppressive agents

Schönenberger, E., Ehrich, J. H. H., Haller, H. G., & Schiffer, M. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq617 · Cited by 129 · see citing works

GmHs1-1, encoding a calcineurin-like protein, controls hard-seededness in soybean

Sun, L., Miao, Z., Cai, C., Zhang, D., Zhao, M., Wu, Y., Zhang, X., Swarm, S. A., Zhou, L., Zhang, Z. J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3339 · Cited by 128 · see citing works

Dopamine D1 Receptors, Regulation of Gene Expression in the Brain, and Neurodegeneration

Cadet, J. L., Jayanthi, S., McCoy, M. T., Beauvais, G., & Cai, N. S. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710793361496 · Cited by 109 · see citing works

Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis

Chen, Y.-L., Brand, A., Morrison, E. L., Silao, F. G. S., Bigol, U. G., Malbas, F. F., Nett, J. E., Andes, D. R., Solis, N. V., Filler, S. G., et al. (2011) · Eukaryotic Cell · doi:10.1128/ec.00310-10 · Cited by 107 · see citing works

Recent Approaches to Antifungal Therapy for Invasive Mycoses

Mathew, B. P., & Nath, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200800353 · Cited by 105 · see citing works

Regulatory T cells: roles of T cell receptor for their development and function

Ohkura, N., & Sakaguchi, S. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0200-5 · Cited by 97 · see citing works

Calcineurin Targets Involved in Stress Survival and Fungal Virulence

Hee-Soo, P., Chow, E. W. L., Fu, C., Soderblom, E. J., Moseley, M. A., Heitman, J., & Cardenas, M. E. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005873 · Cited by 94 · see citing works

Regulation of T‐cell tolerance by calcium/NFAT signaling

Baine, I. L., Abe, B. T., & Macián, F. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00817.x · Cited by 92 · see citing works

Brawn for Brains: The Role of MEF2 Proteins in the Developing Nervous System

Shalizi, A., & Bonni, A. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)69009-6 · Cited by 86 · see citing works

Calcineurin Regulation in Fungi and Beyond

Stie, J., & Fox, D. S. (2007) · Eukaryotic Cell · doi:10.1128/ec.00326-07 · Cited by 89 · see citing works

The podocyte as a direct target for treatment of glomerular disease?

Mallipattu, S. K., & He, C. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00184.2016 · Cited by 84 · see citing works

What Causes a Broken Heart—Molecular Insights into Heart Failure

Barry, S. P., & Townsend, P. A. (2010) · International review of cytology · doi:10.1016/s1937-6448(10)84003-1 · Cited by 78 · see citing works

Alternative splicing and expression of human and mouse NFAT genes

Vihma, H., Pruunsild, P., & Timmusk, T. (2008) · Genomics · doi:10.1016/j.ygeno.2008.06.011 · Cited by 79 · see citing works

Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor

Santos, M., & de Larrinoa, I. F. (2005) · Current Genetics · doi:10.1007/s00294-005-0003-8 · Cited by 78 · see citing works

Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways

Kullas, A. L., Martin, S. J., & Davis, D. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05929.x · Cited by 75 · see citing works

Podocyte-targeted therapies — progress and future directions

Meliambro, K. A., He, C., & Campbell, K. N. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00843-z · Cited by 77 · see citing works

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

Pineda, J. R., Pardo, R., Zala, D., Yu, H., Humbert, S., & Saudou, F. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-33 · Cited by 76 · see citing works

HIV-1, Methamphetamine and Astrocyte Glutamate Regulation: Combined Excitotoxic Implications for Neuro-AIDS

Cisneros, I. E., & Ghorpade, A. (2012) · Current HIV Research · doi:10.2174/157016212802138832 · Cited by 74 · see citing works

NF-κB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-κB site in the ICAM-1 gene

Xue, J., Thippegowda, P. B., Hu, G., Bachmaier, K., Christman, J. W., Malik, A. B., & Tiruppathì, C. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00012.2009 · Cited by 75 · see citing works

Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin

Mehta, S., Aye-Han, N.-N., Ganesan, A., Oldach, L., Gorshkov, K., & Zhang, J. (2014) · eLife · doi:10.7554/elife.03765 · Cited by 74 · see citing works

Blockade of NFAT Activation by the Second Calcineurin Binding Site

Martı́nez-Martı́nez, S., Rodrı́guez, A., López-Maderuelo, D., Ortega‐Pérez, I., Vázquez, J., & Redondo, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513885200 · Cited by 72 · see citing works

Calcium and Cell Death

Verkhratsky, A. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6191-2_17 · Cited by 68 · see citing works

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

Mukherjee, A., Morales‐Scheihing, D., Gonzalez-Romero, D., Green, K. M., Taglialatela, G., & Soto, C. A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001138 · Cited by 65 · see citing works

Isoproterenol Cytotoxicity is Dependent on the Differentiation State of the Cardiomyoblast H9c2 Cell Line

Branco, A. F., Pereira, S. L., Moreira, A. C., Holy, J. M., Sardão, V. A., & Oliveira, P. J. (2011) · Cardiovascular Toxicology · doi:10.1007/s12012-011-9111-5 · Cited by 64 · see citing works

SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation

Zhu, Z., Yu, T., Liu, H., Jin, J., & He, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0073-9 · Cited by 62 · see citing works

Peptide Microarray for High‐Throughput Determination of Phosphatase Specificity and Biology

Sun, H., Lu, C. H. S., Uttamchandani, M., Xia, Y. F., Liou, Y., & Yao, S. Q. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200703473 · Cited by 61 · see citing works

Gene Expression Changes and Signaling Events Associated with the Direct Antimelanoma Effect of IFN-γ

Gollob, J., Sciambi, C. J., Huang, Z., & Dressman, H. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1387 · Cited by 61 · see citing works

Calcineurin Colocalizes with P-Bodies and Stress Granules during Thermal Stress in Cryptococcus neoformans

Kozubowski, L., Aboobakar, E. F., Cardenas, M. E., & Heitman, J. (2011) · Eukaryotic Cell · doi:10.1128/ec.05087-11 · Cited by 60 · see citing works

Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders

Mizuguchi, T., Nakashima, M., Kato, M., Okamoto, N., Kurahashi, H., Ekhilevitch, N., Shiina, M., Nishimura, G., Shibata, T., Matsuo, M., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy052 · Cited by 58 · see citing works

A Calcineurin-dependent Switch Controls the Trafficking Function of α-Arrestin Aly1/Art6

O’Donnell, A. F., Huang, L., Thorner, J. W., & Cyert, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.478511 · Cited by 58 · see citing works

Signaling regulation of fetoplacental angiogenesis

Wang, K., & Zheng, J. J. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0296 · Cited by 58 · see citing works

Inseparable tandem: evolution chooses ATP and Ca 2+ to control life, death and cellular signalling

Plattner, H., & Verkhratsky, A. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0419 · Cited by 62 · see citing works

Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: A possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells

Matta, C., Fodor, J., Szíjgyártó, Z., Juhász, T., Gergely, P., Csernoch, L. J., & Zákány, R. (2008) · Cell Calcium · doi:10.1016/j.ceca.2007.12.010 · Cited by 55 · see citing works

Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

Takeuchi, K., Roehrl, M. H. A., Sun, Z., & Wagner, G. (2007) · Structure · doi:10.1016/j.str.2007.03.015 · Cited by 55 · see citing works

Updates in the treatment of ocular allergies

Saari, K. M. (2010) · Journal of Asthma and Allergy · doi:10.2147/jaa.s13705 · Cited by 54 · see citing works

Calcineurin in development and disease

Chen, L., Song, M., & Yao, C. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.03.002 · Cited by 53 · see citing works

Global distribution of treatment resistance gene markers for leishmaniasis

Salari, S., Bamorovat, M., Sharifi, I., & Almani, P. G. N. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24599 · Cited by 52 · see citing works

Cyclooxygenase-2 Induction by Arsenite Is through a Nuclear Factor of Activated T-cell-dependent Pathway and Plays an Antiapoptotic Role in Beas-2B Cells

Ding, J., Li, J., Xue, C., Wu, K., Ouyang, W., Zhang, D., Yan, Y., & Huang, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600751200 · Cited by 51 · see citing works

Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes

Buvall, L., Wallentin, H., Sieber, J., Andreeva, S. G., Choi, H. Y., Mundel, P. H., & Greka, A. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016040414 · Cited by 51 · see citing works

Participation of CWI, HOG and Calcineurin pathways in the tolerance of Saccharomyces cerevisiae to low pH by inorganic acid

de Lucena, R. M., Elsztein, C., Simões, D. A., & de Morais, M. A. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05362.x · Cited by 50 · see citing works

Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: Identification of a subpopulation of reactive astrocytes

Serrano‐Pérez, M. C., Martín, E. D., Vaquero, C. F., Azcoitia, Í., Calvo, S., Cano, E., & Tranque, P. (2010) · Glia · doi:10.1002/glia.21079 · Cited by 47 · see citing works

The Ca2+/Calcineurin-Dependent Signaling Pathway in the Gray Mold Botrytis cinerea: The Role of Calcipressin in Modulating Calcineurin Activity

Harren, K., Schumacher, J., & Tudzynski, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041761 · Cited by 46 · see citing works

Calcium signaling in closely related protozoan groups (Alveolata): Non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma)

Plattner, H., Sehring, I. M., Mohamed, I. K., de Miranda, K. R., de Souza, W., Billington, R. A., Genazzani, A. A., & Ladenburger, E. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.01.006 · Cited by 46 · see citing works

Myb proteins regulate the expression of diverse target genes

Lang, G., White, J. R., Argent-Katwala, M., Allinson, C. G., & Weston, K. (2004) · Oncogene · doi:10.1038/sj.onc.1208301 · Cited by 45 · see citing works

Transcriptional regulation of T cell tolerance

Bandyopadhyay, S., Soto-Nieves, N., & Macián, F. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.02.006 · Cited by 42 · see citing works

A new and clinically relevant murine model of solid-organ transplant aspergillosis

Herbst, S., Shah, A., Carby, M. R., Chusney, G. D., Naresh, K. N., Dorling, A., Bignell, E., Shaunak, S., & Armstrong-James, D. P. H. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010330 · Cited by 40 · see citing works

The Role of the Regulatory Subunit of Fission Yeast Calcineurin for in Vivo Activity and Its Relevance to FK506 Sensitivity

Sio, S. O., Suehiro, T., Sugiura, R., Takeuchi, M., Mukai, H., & Kuno, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414234200 · Cited by 40 · see citing works

On the Roles of Calcineurin in Fungal Growth and Pathogenesis

Chen, Y., Kozubowski, L., Cardenas, M. E., & Heitman, J. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0027-5 · Cited by 39 · see citing works

NFAT regulates calcium-sensing receptor-mediated TNF production

Abdullah, H. I., Pedraza, P. L., Hao, S., Rodland, K., McGiff, J. C., & Ferreri, N. R. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00223.2005 · Cited by 39 · see citing works

Roles of Cch1 and Mid1 in Morphogenesis, Oxidative Stress Response and Virulence in Candida albicans

Yu, Q., Wang, H., Cheng, X., Xu, N., Ding, X., Xing, L., & Li, M. (2012) · Mycopathologia · doi:10.1007/s11046-012-9569-0 · Cited by 38 · see citing works

Interplay between calcineurin and the Slt2 MAP-kinase in mediating cell wall integrity, conidiation and virulence in the insect fungal pathogen Beauveria bassiana

Huang, S., He, Z., Zhang, S., Keyhani, N. O., Song, Y., Yang, Z., Jiang, Y., Zhang, W., Pei, Y., & Zhang, Y. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.08.009 · Cited by 35 · see citing works

Role of podocytes in lupus nephritis

Trivedi, S., Zeier, M., & Reiser, J. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp427 · Cited by 35 · see citing works

A comparative transcriptomic study of vitamin E and an algae-based antioxidant as antioxidative agents: Investigation of replacing vitamin E with the algae-based antioxidant in broiler diets

Xiao, R., Power, R. F., Mallonee, D. H., Crowdus, C. A., Brennan, K. M., Ao, T., Pierce, J. L., & Dawson, K. A. (2010) · Poultry Science · doi:10.3382/ps.2010-01018 · Cited by 34 · see citing works

hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism

Perez‐Neut, M., Rao, V. R., & Gentile, S. (2015) · Oncotarget · doi:10.18632/oncotarget.3797 · Cited by 34 · see citing works

Down Syndrome Critical Region-1 Is a Transcriptional Target of Nuclear Factor of Activated T Cells-c1 within the Endocardium during Heart Development

Wu, H., Kao, S.-C., Barrientos, T., Baldwin, S. H., Olson, E. N., Crabtree, G. R., Zhou, B., & Chang, C.-P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703622200 · Cited by 34 · see citing works

Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans

Fu, C., Donadio, N., Cardenas, M. E., & Heitman, J. (2017) · Genetics · doi:10.1534/genetics.117.300422 · Cited by 33 · see citing works

Structural basis of calcineurin activation by calmodulin

Ye, Q., Feng, Y.-D., Yin, Y., Faucher, F., Currie, M. A., Rahman, M. N., Jin, J., Li, S., Wei, Q., & Jia, Z. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.08.033 · Cited by 33 · see citing works

Transcriptome Comparison Reveals the Adaptive Evolution of Two Contrasting Ecotypes of Zn/Cd Hyperaccumulator Sedum alfredii Hance

Yang, Q., Shohag, M. J. I., Feng, Y., He, Z. L., & Yang, X. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00425 · Cited by 32 · see citing works

Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP‐1 and p38

Escolano, A., Martı́nez-Martı́nez, S., Alfranca, A., Urso, K., Izquierdo, H. M., Delgado, M., Martı́n, F., Sabio, G., Sancho, D., Arco, P. G., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386369 · Cited by 31 · see citing works

Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury

Li, H., Zhang, W., Zhong, F., Das, G. C., Xie, Y., Li, Z., Cai, W., Jiang, G., Choi, J. W., Sidani, M. A., et al. (2018) · Kidney International · doi:10.1016/j.kint.2018.07.023 · Cited by 31 · see citing works

Protein Phosphatase 3 Differentially Modulates Vascular Endothelial Growth Factor- and Fibroblast Growth Factor 2-Stimulated Cell Proliferation and Signaling in Ovine Fetoplacental Artery Endothelial Cells1

Wang, K., Song, Y., Chen, D., & Zheng, J. J. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.068957 · Cited by 29 · see citing works

Immunosuppressants Affect Human Neural Stem Cells In Vitro but Not in an In Vivo Model of Spinal Cord Injury

Sontag, C. J., Nguyen, H. X., Kamei, N., Uchida, N., Anderson, A. J., & Cummings, B. J. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0175 · Cited by 29 · see citing works

Protein Phosphatase 2B (PP2B, Calcineurin) in Paramecium: Partial Characterization Reveals That Two Members of the Unusually Large Catalytic Subunit Family Have Distinct Roles in Calcium-Dependent Processes

Fraga, D., Sehring, I. M., Kissmehl, R., Reiss, M., Gaines, R., Hinrichsen, R. D., & Plattner, H. (2010) · Eukaryotic Cell · doi:10.1128/ec.00322-09 · Cited by 27 · see citing works

Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis

Banki, E., Fisi, V., Moser, S. C., Wengi, A., Carrel, M., Loffing‐Cueni, D., Pentón, D., Kratschmar, D. V., Rizzo, L., Lienkamp, S. S., et al. (2021) · Kidney International · doi:10.1016/j.kint.2021.06.030 · Cited by 26 · see citing works

A Cytoplasmic New Catalytic Subunit of Calcineurin in Trypanosoma cruzi and Its Molecular and Functional Characterization

Orrego, P. R., Olivares, H., Cordero, E. M., Bressan, A., Cortéz, M., Sagua, H., Neira, I., González, J., da Silveira, J. F., Yoshida, N., et al. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002676 · Cited by 26 · see citing works

Signal Transduction Cascades Regulating Differentiation and Virulence in Botrytis cinerea

Schumacher, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23371-0_13 · Cited by 26 · see citing works

Calcineurin is an important factor involved in glucose uptake in human adipocytes

Fonseca, A. C. R. G., Carvalho, E., Eriksson, J. W., & Pereira, M. J. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3261-0 · Cited by 26 · see citing works

The Vertebrate RCAN Gene Family: Novel Insights into Evolution, Structure and Regulation

Serrano‐Candelas, E., Farré, D., Aranguren‐Ibáñez, Á., Martínez-Høyer, S., & Pérez‐Riba, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085539 · Cited by 25 · see citing works

Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis

Zhu, H., Gao, W., Jiang, H. L., Wu, J., Shi, Y., & Zhang, X. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.008 · Cited by 25 · see citing works

Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca 2+ Homeostasis in Aspergillus nidulans

Wang, S., Liu, X., Qian, H., Zhang, S., & Lü, L. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.00330-16 · Cited by 24 · see citing works

Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart

Otani, K., Tokudome, T., Kamiya, C., Mao, Y., Nishimura, H., Hasegawa, T., Arai, Y., Kaneko, M., Shioi, G., Ishida, J., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.039761 · Cited by 23 · see citing works

Stimulating Fungi Pleurotus ostreatus with Hydrocortisone

Dehshibi, M. M., Chiolerio, A., Nikolaidou, A. E., Mayne, R., Gandía, A., Ashtari-Majlan, M., & Adamatzky, A. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00752 · Cited by 21 · see citing works

Association of Calcineurin with the COPI Protein Sec28 and the COPII Protein Sec13 Revealed by Quantitative Proteomics

Kozubowski, L., Thompson, J. W., Cardenas, M. E., Moseley, M. A., & Heitman, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025280 · Cited by 22 · see citing works

An Antiproliferative Genetic Screening Identifies a Peptide Aptamer That Targets Calcineurin and Up-regulates Its Activity

de Chassey, B., Mikaélian, I., Mathieu, A., Bickle, M., Olivier, D., Négre, D., Cosset, F., Rudkin, B. B., & Colas, P. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600102-mcp200 · Cited by 22 · see citing works

Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy

Barzegar‐Fallah, A., Alimoradi, H., Razmi, A., Dehpour, A. R., Asgari, M., & Shafiei, M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.019 · Cited by 21 · see citing works

Effect of cyclosporin A on proteinuria in the course of glomerulopathy associated with WT1 mutations

Wasilewska, A. M., Kuroczycka–Saniutycz, E., & Zoch-Zwierz, W. M. (2010) · European Journal of Pediatrics · doi:10.1007/s00431-010-1278-4 · Cited by 20 · see citing works

Downregulation of Calcineurin Gene Is Associated with Glucantime(®) Resiatance in Leishmania infantum.

Erfan, M. B. K., Mohebali, M., Kazemirad, E., Hajjaran, H., Edrissian, G., Mamishi, S., Saffari, M., Raoofian, R., & Heidari, M. (2013) · Europe PMC (PubMed Central) · Cited by 20 · see citing works

Effects of Ultraviolet A‐1 Radiation on Calcineurin Activity and Cytokine Production in (Skin) Cell Cultures†

Smit, N. P. M., Musson, R. E. A., Romijn, F. P. H. T. M., van Rossum, H. H., & PELT, J. V. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00650.x · Cited by 20 · see citing works

Calcineurin Activity and Inhibition in Skin and (Epi)Dermal Cell Cultures

Smit, N. P. M., van Rossum, H. H., Romijn, F. P. H. T. M., Sellar, K. J., Breetveld, M., Gibbs, S., & PELT, J. V. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701244 · Cited by 19 · see citing works

Chapter 5 Pharmacology of Ciliated Protozoa—Drug (In)Sensitivity and Experimental Drug (Ab)Use

Plattner, H., Sehring, I. M., Schilde, C., & Ladenburger, E. (2009) · International review of cytology · doi:10.1016/s1937-6448(08)01805-4 · Cited by 19 · see citing works

Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role

Tang, H., Sun, Y. N., Xiu, Q., Lu, H. Y., & Han, H.-X. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.09.016 · Cited by 18 · see citing works

The C2 Domain Protein Cts1 Functions in the Calcineurin Signaling Circuit during High-Temperature Stress Responses in Cryptococcus neoformans

Aboobakar, E. F., Wang, X., Heitman, J., & Kozubowski, L. (2011) · Eukaryotic Cell · doi:10.1128/ec.05148-11 · Cited by 17 · see citing works

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans

Jung, W. H., Son, Y.-E., Oh, S., Fu, C., Kim, H., Kwak, J., Cardenas, M. E., Heitman, J., & Park, H.-S. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.300444 · Cited by 17 · see citing works

Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade

Ding, Y., Tang, X., Wang, Y., Yu, D., Zhu, C., & Yu, J. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03469-x · Cited by 16 · see citing works

Emerging Targets of the GnRH Receptor: Novel Interactions with Wnt Signalling Mediators

Gardner, S., & Pawson, A. J. (2008) · Neuroendocrinology · doi:10.1159/000165377 · Cited by 16 · see citing works

FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-βand Smads signal pathways

Ren, Q., Li, W., & Yu, S. (2014) · Renal Failure · doi:10.3109/0886022x.2014.882713 · Cited by 15 · see citing works

Calcineurin regulates phosphorylation status of transcription factor osterix

Okamura, H., Amorim, B. R., Wang, J., Yoshida, K., & Haneji, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.094 · Cited by 15 · see citing works

From phagocytosis to metaforosis: Calcineurin’s deadly role in innate processing of fungi

Armstrong-James, D. P. H., de Boer, L. L., Bercusson, A., & Shah, A. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006627 · Cited by 13 · see citing works

Calcineurin Plays an Important Role in the Shell Formation of Pearl Oyster (Pinctada fucata)

Li, C., Hu, Y., Liang, J., Kong, Y., Huang, J. L., Feng, Q., Li, S., Zhang, G., Xie, L., & Zhang, R. (2009) · Marine Biotechnology · doi:10.1007/s10126-009-9204-3 · Cited by 13 · see citing works

Cellular and Molecular Consequences of Calcineurin Aα Gene Deletion

Sun, L., Zhu, L.-L., Zaidi, N., Yang, G., Moonga, B. S., Abe, E., Iqbal, J. Z., Epstein, S., Blair, H. C., Huang, C. L.-H., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.050 · Cited by 13 · see citing works

Workshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function

Aramburu, J. F., Heitman, J., & Crabtree, G. R. (2004)

Calcineurin/NFAT signalling regulates cell cycle progression

Shimada, M. (2020) · The Japanese Biochemical Society

Calcineurin/NFAT Pathway : A Novel Regulator of Parturition

田畑, 知. (2009) · Cited by 1 · see citing works

[Cell regulation through calcineurin signalling].

Sugiura, R., Shuntoh, H., & Kuno, T. (2005) · PubMed · Cited by 1 · see citing works

Molecular mechanisms underlying the functional diversity of calcineurin/NFAT signaling

Kaminuma, O. (2020) · The Japanese Biochemical Society