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Cited by 74Sleep and Wakefulness ResearchSleep and Work-Related FatigueCircadian rhythm and melatonin

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

The inescapable drive to sleep: Overlapping mechanisms of sleep and sedation

Franks, Nicholas P., Wisden, William·2021·Science
DOI 10.1126/science.abi8372
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Abstract

Common human experience is that a long period without sleep is unsustainable, and it is also detrimental to health and behavior. The powerful and primal urge to sleep after sleep deprivation is intense and seems inescapable. The longer we stay awake, the more we feel the need to sleep, and however much we resist, we will inevitably succumb. Although it is obvious what benefits derive from other common and strong physiological drives, such as hunger, sex, and thirst, it is less obvious what drives us to sleep and what benefits accrue. Understanding the biochemical or circuit basis for the sleep drive could enable the benefits of sleep to be artificially stimulated with a new generation of sedative drugs.

Overview

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Registry

Crossref · 10.1126/science.abi8372

Cites

8 of 8 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Anesthetics at sedative doses induce states resembling deep NREM sleep.

    “Anesthetics at sedative doses, which induce states resembling deep NREM sleep2,13, were also reported to increase clearance3,14,15.”

    From Brain clearance is reduced during sleep and anesthesia (2024) · cites this paper as [2]

Citations

Cites

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Research works printed but not linked: 43

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Metadata

Authors
Franks, N. P., & Wisden, W.
Affiliations
UK Dementia Research Institute (GB)
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-10-29
Volume
374
Issue
6567
Pages
556-559
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.abi8372
OpenAlex
W3208500063
Cited by
74
References
8
Citations by year
2026: 20 · 2025: 12 · 2024: 12 · 2023: 17 · 2022: 12 · 2021: 1
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust (107839/Z/15/Z, 220759/Z/20/Z)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
sleep drive, sleep deprivation, sedation, sleep regulation, sleep homeostasis, sedatives, sleep promotion
MeSH terms
Animals, Body Temperature, Brain, Homeostasis, Humans, Hypnotics and Sedatives, Sleep, Sleep Stages, Procedural Sedation

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