Schopfer, Francisco J.

Nitrolinoleic acid. An endogenous peroxisome proliferator-activated receptor γ ligand

Schopfer, F. J., Lin, Y., Baker, P. R. S., Cui, T., Garcia-Barrio, M., Zhang, J., Chen, K., Chen, Y. E., & Freeman, B. A. (2005) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health

Cited by 428

Fatty Acid Transduction of Nitric Oxide Signaling

Baker, P. R. S., Lin, Y., Schopfer, F. J., Woodcock, S. R., Groeger, A. L., Batthyany, C., Sweeney, S., Long, M. H., Iles, K. E., Baker, L. M. S., et al. (2005) · Journal of Biological Chemistry

Fatty Acid Research and HealthPeroxisome Proliferator-Activated Receptors

Cited by 358

Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators

Cui, T., Schopfer, F. J., Zhang, J., Chen, K., Ichikawa, T., Baker Paul, R. S., Batthyany, C., Chacko, B. K., Feng, X., Patel, R. P., et al. (2006) · Journal of Biological Chemistry

Fatty Acid Research and HealthInflammatory mediators and NSAID effects

Cited by 351

Formation and signaling actions of electrophilic lipids

Schopfer, F. J., Cipollina, C., & Freeman, B. A. (2011) · Chemical Reviews

Genomics, phytochemicals, and oxidative stressEicosanoids and Hypertension Pharmacology

Cited by 299

Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

Groeger, A. L., Cipollina, C., Cole, M. P., Woodcock, S. R., Bonacci, G., Rudolph, T. K., Rudolph, V., Freeman, B. A., & Schopfer, F. J. (2010) · Nature Chemical Biology

Fatty Acid Research and HealthInflammatory mediators and NSAID effects

Cited by 295

Reversible Post-translational Modification of Proteins by Nitrated Fatty Acids in Vivo

Batthyany, C., Schopfer, F. J., Baker, P. R. S., Durán, R., Baker, L. M. S., Huang, Y., Cerveñansky, C., Branchaud, B. P., & Freeman, B. A. (2006) · Journal of Biological Chemistry

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 285

Nitro-fatty acid formation and signaling

Freeman, B. A., Baker, P. R. S., Schopfer, F. J., Woodcock, S. R., Napolitano, A., & d'Ischia, M. (2008) · Journal of Biological Chemistry

Fatty Acid Research and HealthRedox biology and oxidative stress

Cited by 265

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism

Kansanen, E., Bonacci, G., Schopfer, F. J., Kuosmanen, S. M., Tong, K. I., Leinonen, H., Woodcock, S. R., Yamamoto, M., Carlberg, C., Ylä-Herttuala, S., et al. (2011) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 208

Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation

Baker, P. R. S., Schopfer, F. J., Sweeney, S., & Freeman, B. A. (2004) · Proceedings of the National Academy of Sciences

Antioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Cited by 201

Nitro-fatty Acid Reaction with Glutathione and Cysteine

Baker, L. M. S., Baker, P. R. S., Golin-Bisello, F., Schopfer, F. J., Fink, M., Woodcock, S. R., Branchaud, B. P., Radi, R., & Freeman, B. A. (2007) · Journal of Biological Chemistry

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 200

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion

Rudolph, V., Rudolph, T. K., Schopfer, F. J., Bonacci, G., Woodcock, S. R., Cole, M. P., Baker, P. R. S., Ramani, R., & Freeman, B. A. (2010) · Cardiovascular Research

Cardiac Ischemia and ReperfusionNitric Oxide and Endothelin Effects

Cited by 188

Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids

Schopfer, F. J., Cole, M. P., Groeger, A. L., Chen, C.-S., Khoo, N. K. H., Woodcock, S. R., Golin-Bisello, F., Motanya, U. N., Li, Y., Zhang, J., et al. (2010) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health

Cited by 171

Molecular recognition of nitrated fatty acids by PPARγ

Li, Y., Zhang, J., Schopfer, F. J., Martynowski, D., Garcia-Barrio, M. T., Kovach, A., Suino-Powell, K., Baker, P. R. S., Freeman, B. A., Chen, Y. E., et al. (2008) · Nature Structural & Molecular Biology

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 168

Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells

Kansanen, E., Jyrkkänen, H.-K., Volger, O. L., Leinonen, H., Kivelä, A. M., Häkkinen, S.-K., Woodcock, S. R., Schopfer, F. J., Horrevoets, A. J., Ylä-Herttuala, S., et al. (2009) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressNitric Oxide and Endothelin Effects

Cited by 165

Conjugated linoleic acid is a preferential substrate for fatty acid nitration

Bonacci, G., Baker, P. R. S., Salvatore, S. R., Shores, D., Khoo, N. K. H., Koenitzer, J. R., Vitturi, D. A., Woodcock, S. R., Golin-Bisello, F., Cole, M. P., et al. (2012) · Journal of Biological Chemistry

Fatty Acid Research and HealthAntioxidant Activity and Oxidative Stress

Cited by 147

Nitro-oleic acid inhibits angiotensin II-induced hypertension

Zhang, J., Villacorta, L., Chang, L., Fan, Z., Hamblin, M., Zhu, T., Chen, C. S., Cole, M. P., Schopfer, F. J., Deng, C. X., et al. (2010) · Circulation Research

Renin-Angiotensin System StudiesEicosanoids and Hypertension Pharmacology

Cited by 121

Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts

Villacorta, L., Chang, L., Salvatore, S. R., Ichikawa, T., Zhang, J., Petrovic-Djergovic, D., Jia, L., Carlsen, H., Schopfer, F. J., Freeman, B. A., et al. (2013) · Cardiovascular Research

Nitric Oxide and Endothelin EffectsAtherosclerosis and Cardiovascular Diseases

Cited by 116

Olives and olive oil are sources of electrophilic fatty acid nitroalkenes

Fazzari, M., Trostchansky, A., Schopfer, F. J., Salvatore, S. R., Sánchez-Calvo, B., Vitturi, D., Valderrama, R., Barroso, J. B., Radi, R., Freeman, B. A., et al. (2014) · PLoS ONE

Edible Oils Quality and AnalysisFatty Acid Research and Health

Cited by 114

Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity

Lim, D. G., Sweeney, S., Bloodsworth, A., White, C. R., Chumley, P. H., Krishna, N. R., Schopfer, F., O'Donnell, V. B., Eiserich, J. P., & Freeman, B. A. (2002) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsEicosanoids and Hypertension Pharmacology

Cited by 110

Nitro–Fatty Acids Reduce Atherosclerosis in Apolipoprotein E–Deficient Mice

Rudolph, T. K., Rudolph, V., Edreira, M. M., Cole, M. P., Bonacci, G., Schopfer, F. J., Woodcock, S. R., Franek, A., Pekarova, M., Khoo, N. K. H., et al. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology

Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

Cited by 109

Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives

Schopfer, F. J., Batthyany, C., Baker, P. R. S., Bonacci, G., Cole, M. P., Rudolph, V., Groeger, A. L., Rudolph, T. K., Nadtochiy, S., Brookes, P. S., et al. (2009) · Free Radical Biology and Medicine

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 104

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

Delmastro-Greenwood, M., Hughan, K. S., Vitturi, D. A., Salvatore, S. R., Grimes, G., Potti, G., Shiva, S., Schopfer, F. J., Gladwin, M. T., Freeman, B. A., et al. (2015) · Free Radical Biology and Medicine

Fatty Acid Research and HealthAntioxidant Activity and Oxidative Stress

Cited by 97

Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling

Rahaman, M. M., Nguyen, A. T., Miller, M. P., Hahn, S. A., Sparacino-Watkins, C., Jobbagy, S., Carew, N. T., Cantu-Medellin, N., Wood, K. C., Baty, C. J., et al. (2017) · Circulation Research

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 92

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine

Salvatore, S. R., Vitturi, D. A., Baker, P. R. S., Bonacci, G., Koenitzer, J. R., Woodcock, S. R., Freeman, B. A., & Schopfer, F. J. (2013) · Journal of Lipid Research

Fatty Acid Research and HealthAntioxidant Activity and Oxidative Stress

Cited by 82