Lauschke, Volker M.

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., Fredriksson Puigvert, L., Dankers, A. C. A., Jacobs, F., Snoeys, J., et al. (2016) · Scientific Reports

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 739

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., Goldring, C. E., Park, K., Regan, S. L., Walker, T., et al. (2018) · Toxicological Sciences

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 327

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

Lauschke, V. M., Hendriks, D. F. G., Bell, C. C., Andersson, T. B., & Ingelman-Sundberg, M. (2016) · Chemical Research in Toxicology

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 241

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury

Bell, C. C., Lauschke, V. M., Vorrink, S. U., Palmgren, H., Duffin, R., Andersson, T. B., & Ingelman-Sundberg, M. (2017) · Drug Metabolism and Disposition

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 201

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Vorrink, S. U., Zhou, Y., Ingelman-Sundberg, M., & Lauschke, V. M. (2018) · Toxicological Sciences

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 187

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

Vorrink, S. U., Ullah, S., Schmidt, S., Nandania, J., Velagapudi, V., Beck, O., Ingelman‐Sundberg, M., & Lauschke, V. M. (2017) · The FASEB Journal

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 172

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

Lauschke, V. M., Shafagh, R. Z., Hendriks, D. F. G., & Ingelman‐Sundberg, M. (2019) · Biotechnology Journal

3D Printing in Biomedical ResearchDrug-Induced Hepatotoxicity and Protection

Cited by 153

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, Å., Hendriks, D. F. G., Bell, C. C., Sison‐Young, R., Park, B. K., Goldring, C. E., et al. (2016) · Hepatology

Liver physiology and pathologyMicroRNA in disease regulation

Cited by 121

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

Zhou, Y., Shen, J. X., & Lauschke, V. M. (2019) · Frontiers in Pharmacology

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 85

3D human liver spheroids for translational pharmacology and toxicology

Ingelman‐Sundberg, M., & Lauschke, V. M. (2022) · Basic & Clinical Pharmacology & Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 62

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Hendriks, D. F. G., Vorrink, S. U., Smutny, T., Sim, S. C., Nordling, Å., Ullah, S., Kumondai, M., Jones, B. C., Johansson, I., Andersson, T. B., et al. (2020) · Clinical Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 57

3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation

Wesseler, M. F., Taebnia, N., Harrison, S., Youhanna, S., Preiss, L. C., Kemas, A. M., Vegvari, A., Mokry, J., Sullivan, G. J., Lauschke, V. M., et al. (2023) · Acta Biomaterialia

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 39

Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds

Preiss, L. C., Lauschke, V. M., Georgi, K., & Petersson, C. (2022) · The AAPS Journal

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 36

The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration

Lauschke, V. M., Mkrtchian, S., & Ingelman-Sundberg, M. (2017) · Biochemical and Biophysical Research Communications

Liver physiology and pathologyMicroRNA in disease regulation

Cited by 29

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Youhanna, S., Taebnia, N., Liang, Y., Cheng, N., Wang, Y., Michel, M., & Lauschke, V. M. (2025) · Advanced Biology

Liver Disease Diagnosis and Treatment3D Printing in Biomedical Research

Cited by 9