Mazmanian, Sarkis K.

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature

Gut microbiota and healthTryptophan and brain disorders

Cited by 489

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O. (2017) · Immunity

Immune responses and vaccinationsNeonatal and Maternal Infections

Cited by 478

Microbiome–microglia connections via the gut–brain axis

Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Cited by 471

Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections

Mazmanian, S. K., Liu, G., Jensen, E. R., Lenoy, E., & Schneewind, O. (2000) · Proceedings of the National Academy of Sciences

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 453

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Sampson, T. R., Challis, C., Jain, N., Moiseyenko, A., Ladinsky, M. S., Shastri, G. G., Thron, T., Needham, B. D., Horvath, I., Debelius, J. W., et al. (2020) · eLife

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 439

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Challis, C., Hori, A., Sampson, T. R., Yoo, B. B., Challis, R. C., Hamilton, A. M., Mazmanian, S. K., Volpicelli-Daley, L. A., & Gradinaru, V. (2020) · Nature Neuroscience

Parkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research

Cited by 405

Sortase‐catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus

Mazmanian, S. K., Ton‐That, H., & Schneewind, O. (2001) · Molecular Microbiology

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 387

Gut microbial molecules in behavioural and neurodegenerative conditions

Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience

Gut microbiota and healthTryptophan and brain disorders

Cited by 379

An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis

Mazmanian, S. K., Ton-That, H., Su, K., & Schneewind, O. (2002) · Proceedings of the National Academy of Sciences

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 372

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus

Ton-That, H., Mazmanian, S. K., Faull, K. F., & Schneewind, O. (2000) · Journal of Biological Chemistry

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 359

Modeling an autism risk factor in mice leads to permanent immune dysregulation

Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences

Autism Spectrum Disorder ResearchTryptophan and brain disorders

Cited by 340

Finding the Missing Links among Metabolites, Microbes, and the Host

Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 317

A gut microbial factor modulates locomotor behaviour in Drosophila

Schretter, C. E., Vielmetter, J., Bartos, I., Marka, Z., Marka, S., Argade, S., & Mazmanian, S. K. (2018) · Nature

Neurobiology and Insect Physiology ResearchGut microbiota and health

Cited by 289

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

Ramakrishna, C., Kujawski, M., Chu, H., Li, L., Mazmanian, S. K., & Cantin, E. M. (2019) · Nature Communications

T-cell and B-cell ImmunologyHerpesvirus Infections and Treatments

Cited by 284

The placental interleukin-6 signaling controls fetal brain development and behavior

Wu, W.-L., Hsiao, E. Y., Yan, Z., Mazmanian, S. K., & Patterson, P. H. (2017) · Brain Behavior and Immunity

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 275

Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence

Bierne, H., Mazmanian, S. K., Trost, M., Pucciarelli, M. G., Liu, G., Dehoux, P., the European Listeria Genome Consortium, Jänsch, L., Portillo, F. G., Schneewind, O., et al. (2002) · Molecular Microbiology

Biochemical and Structural CharacterizationListeria monocytogenes in Food Safety

Cited by 223

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus

Perry, A. M., Ton-That, H., Mazmanian, S. K., & Schneewind, O. (2002) · Journal of Biological Chemistry

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 218

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Baloni, P., Funk, C. C., Yan, J., Yurkovich, J. T., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., et al. (2020) · Cell Reports Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 211

Intestinal Microbes in Inflammatory Bowel Diseases

Sartor, R. B., & Mazmanian, S. K. (2012) · The American Journal of Gastroenterology Supplements

Gut microbiota and healthInflammatory Bowel Disease

Cited by 206

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus

Ton-That, H., Mazmanian, S. K., Alksne, L., & Schneewind, O. (2002) · Journal of Biological Chemistry

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 159

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 150

On the Role of Staphylococcus aureus Sortase and Sortase‐Catalyzed Surface Protein Anchoring in Murine Septic Arthritis

Jonsson, I., Mazmanian, S. K., Schneewind, O., Verdrengh, M., Bremell, T., & Tarkowski, A. (2002) · The Journal of Infectious Diseases

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 102

The Structure of Sortase B, a Cysteine Transpeptidase that Tethers Surface Protein to the Staphylococcus aureus Cell Wall

Zong, Y., Mazmanian, S. K., Schneewind, O., & Narayana, S. V. L. (2004) · Structure

Biochemical and Structural CharacterizationAntimicrobial Resistance in Staphylococcus

Cited by 91

A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

Abdel-Haq, R., Schlachetzki, J. C., Boktor, J. C., Cantu-Jungles, T. M., Thron, T., Zhang, M., Bostick, J. W., Khazaei, T., Chilakala, S., Morais, L. H., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 82