Finding the Missing Links among Metabolites, Microbes, and the Host
Open accessAbstract
The unexpected diversity of the human microbiome and metabolome far exceeds the complexity of the human genome. Although we now understand microbial taxonomic and genetic repertoires in some populations, we are just beginning to assemble the necessary computational and experimental tools to understand the metabolome in comparable detail. However, even with the limited current state of knowledge, individual connections between microbes and metabolites, between microbes and immune function, and between metabolites and immune function are being established. Here, we provide our perspective on these connections and outline a systematic research program that could turn these individual links into a broader network that allows us to understand how these components interact. This program will enable us to exploit connections among the microbiome, metabolome, and host immune system to maintain health and perhaps help us understand how to reverse the processes that lead to a wide range of immune and other diseases.
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The gut microbiota influences the relative populations, migration, and function of various subsets of immune cells including Helper T cells, Regulatory T cells, mononuclear phagocytes and innate lymphoid cells.
“The gut microbiota influences the relative populations, migration, and function of various subsets of immune cells including Helper T cells, Regulatory T cells, mononuclear phagocytes and innate lymphoid cells (Dorrestein et al., 2014;Rooks and Garrett, 2016)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Dorrestein et al., 2014
The 'Microbial metabolism and inflammation' section reports that gut microbial metabolites increase regulatory T-cell numbers and function in mouse models, and describes effects on innate immune-cell development. The passages found do not establish effects on cell migration or specifically identify helper T cells, mononuclear phagocytes, or innate lymphoid cells as affected subsets. (LLM, conf=0.85)
Experimental — accuracy not yet measuredSCFAs have been shown to impact T cell immune responses.
“SCFAs have been shown to impact on T cell immune responses37.”
From Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer (2021) · cites this paper as [37]
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Dopamine receptor D2 confers colonization resistance via microbial metabolites
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- Authors
- Dorrestein, P. C., Mazmanian, S. K., & Knight, R.
- Affiliations
- University of California San Diego (US)
- California Institute of Technology (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Knight, Rob
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 40
- Issue
- 6
- Pages
- 824-832
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4503329
- OpenAlex
- W2056978288
- Cited by
- 317
- References
- 76
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 32 · 2023: 29 · 2022: 27 · 2021: 30 · 2020: 38 · 2019: 28 · 2018: 21 · 2017: 22 · 2016: 28 · 2015: 26 · 2014: 11
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Mental Health (R01MH100556)
- National Human Genome Research Institute (U01HG004866, R01HG004872)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078938, P01DK078669)
- National Institute of Neurological Disorders and Stroke (R01NS085910)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- human microbiome, human metabolome, host-microbe interactions, microbial metabolites, host immune function, microbial diversity, immune disorders, metabolomics
- MeSH terms
- Bacterial Proteins, Humans, Gastrointestinal Tract, Metagenome, Metabolome, Microbiota
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