Cravatt, Benjamin F.

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

Lichtman, A. H., Shelton, C. C., Advani, T., & Cravatt, B. F. (2004) · Pain

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 301

FAAH genetic variation enhances fronto-amygdala function in mouse and human

Dincheva, I., Drysdale, A. T., Hartley, C. A., Johnson, D. C., Jing, D., King, E. C., Ra, S., Gray, J. M., Yang, R., DeGruccio, A. M., et al. (2015) · Nature Communications

Cannabis and Cannabinoid ResearchMemory and Neural Mechanisms

Cited by 289

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)—a general method for mapping sites of probe modification in proteomes

Weerapana, E., Speers, A. E., & Cravatt, B. F. (2007) · Nature Protocols

Advanced Proteomics Techniques and ApplicationsClick Chemistry and Applications

Cited by 276

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta, A. B., Suciu, R. M., Roper, J., Luopajärvi, K., Markelin, E., Gopalakrishnan, S., et al. (2019) · Nature

Wnt/β-catenin signaling in development and cancerDigestive system and related health

Cited by 271

Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling

Azad, S. C., Monory, K., Marsicano, G., Cravatt, B. F., Lutz, B., Zieglgänsberger, W., & Rammes, G. (2004) · The Journal of Neuroscience

Cannabis and Cannabinoid ResearchMemory and Neural Mechanisms

Cited by 263

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

Bar-Peled, L., Kemper, E. K., Suciu, R. M., Vinogradova, E. V., Backus, K. M., Horning, B. D., Paul, T. A., Ichu, T.-A., Svensson, R. U., Olucha, J., et al. (2017) · Cell

Genomics, phytochemicals, and oxidative stressLung Cancer Treatments and Mutations

Cited by 262

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

Hsu, K.-L., Tsuboi, K., Adibekian, A., Pugh, H., Masuda, K., & Cravatt, B. F. (2012) · Nature Chemical Biology

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 222

The endogenous cannabinoid system and its role in nociceptive behavior

Cravatt, B. F., & Lichtman, A. H. (2004) · Journal of Neurobiology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 203

DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras

Zhang, X., Luukkonen, L. M., Eissler, C. L., Crowley, V. M., Yamashita, Y., Schafroth, M. A., Kikuchi, S., Weinstein, D. S., Symons, K. T., Nordin, B. E., et al. (2021) · Journal of the American Chemical Society

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 199

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

Blewett, M. M., Xie, J., Zaro, B. W., Backus, K. M., Altman, A., Teijaro, J. R., & Cravatt, B. F. (2016) · Science Signaling

Click Chemistry and ApplicationsRedox biology and oxidative stress

Cited by 194

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

Naidu, P. S., Varvel, S. A., Ahn, K., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2007) · Psychopharmacology

Cannabis and Cannabinoid ResearchTreatment of Major Depression

Cited by 184

How Chemoproteomics Can Enable Drug Discovery and Development

Moellering, R. E., & Cravatt, B. F. (2012) · Chemistry & Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 182

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

Wang, Y., Dix, M. M., Bianco, G., Remsberg, J. R., Lee, H.-Y., Kalocsay, M., Gygi, S. P., Forli, S., Vite, G., Lawrence, R. M., et al. (2019) · Nature Chemistry

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 179

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

Kinsey, S. G., O'Neal, S. T., Long, J. Z., Cravatt, B. F., & Lichtman, A. H. (2011) · Pharmacology Biochemistry and Behavior

Cannabis and Cannabinoid ResearchMedicinal Plant Extracts Effects

Cited by 170

Repeated Low-Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains Cannabinoid Receptor Type 1–Mediated Antinociceptive and Gastroprotective Effects

Kinsey, S. G., Wise, L. E., Ramesh, D., Abdullah, R., Selley, D. E., Cravatt, B. F., & Lichtman, A. H. (2013) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 169

Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala

Patel, S., Cravatt, B. F., & Hillard, C. J. (2005) · Neuropsychopharmacology

Cannabis and Cannabinoid ResearchStress Responses and Cortisol

Cited by 164

Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors

Niphakis, M. J., Cognetta, A. B., Chang, J. W., Buczynski, M. W., Parsons, L. H., Byrne, F., Burston, J. J., Chapman, V., & Cravatt, B. F. (2013) · ACS Chemical Neuroscience

Cannabis and Cannabinoid ResearchEnzyme function and inhibition

Cited by 157

In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML 29: antinociceptive activity without cannabimimetic side effects

Ignatowska‐Jankowska, B. M., Ghosh, S., Crowe, M. S., Kinsey, S. G., Niphakis, M. J., Abdullah, R. A., Tao, Q., O' Neal, S. T., Walentiny, D. M., Wiley, J. L., et al. (2014) · British Journal of Pharmacology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 128

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

Ghosh, S., Wise, L. E., Chen, Y., Gujjar, R., Mahadevan, A., Cravatt, B. F., & Lichtman, A. H. (2013) · Life Sciences

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 127

Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals

Nyilas, R., Dudok, B., Urbán, G. M., Mackie, K., Watanabe, M., Cravatt, B. F., Freund, T. F., & Katona, I. (2008) · The Journal of Neuroscience

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 119

Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms

Kinsey, S. G., Long, J. Z., Cravatt, B. F., & Lichtman, A. H. (2010) · The Journal of Pain

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 118

The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice

Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., & Lichtman, A. H. (2012) · British Journal of Pharmacology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 116

Localization of N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) expression in mouse brain: A new perspective on N‐acylethanolamines as neural signaling molecules

Egertová, M., Simon, G. M., Cravatt, B. F., & Elphick, M. R. (2008) · Journal of Comparative Neurology

Cannabis and Cannabinoid ResearchLipid metabolism and biosynthesis

Cited by 111

Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase

Naidu, P. S., Kinsey, S. G., Guo, T. L., Cravatt, B. F., & Lichtman, A. H. (2010) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 108