Cravatt, Benjamin F.

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling

Alpár, A., Tortoriello, G., Calvigioni, D., Niphakis, M. J., Milenkovic, I., Bakker, J., Cameron, G. A., Hanics, J., Morris, C. V., Fuzik, J., et al. (2014) · Nature Communications

Cannabis and Cannabinoid ResearchAxon Guidance and Neuronal Signaling

Cited by 96

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects

Godlewski, G., Alapafuja, S. O., Bátkai, S., Nikas, S. P., Cinar, R., Offertáler, L., Osei-Hyiaman, D., Liu, J., Mukhopadhyay, B., Harvey-White, J., et al. (2010) · Chemistry & Biology

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 95

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Habib, A., Chokr, D., Wan, J., Hegde, P., Mabire, M., Siebert, M., Ribeiro-Parenti, L., Le Gall, M., Lettéron, P., Pilard, N., et al. (2019) · Gut

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 91

Chemoproteomic profiling and discovery of protein electrophiles in human cells

Matthews, M. L., He, L., Horning, B. D., Olson, E. J., Correia, B. E., Yates, J. R., Dawson, P. E., & Cravatt, B. F. (2017) · Nature Chemistry

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 90

Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity

Zhang, Z., Wang, W., Zhong, P., Liu, S. J., Long, J. Z., Zhao, L., Gao, H., Cravatt, B. F., & Liu, Q. (2015) · Hippocampus

Cannabis and Cannabinoid ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 89

Global strategies to integrate the proteome and metabolome

Saghatelian, A., & Cravatt, B. F. (2005) · Current Opinion in Chemical Biology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 85

Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake

Serrano, A., Pavon, F. J., Buczynski, M. W., Schlosburg, J., Natividad, L. A., Polis, I. Y., Stouffer, D. G., Zorrilla, E. P., Roberto, M., Cravatt, B. F., et al. (2018) · Neuropsychopharmacology

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 83

Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition

Rossi, S., De Chiara, V., Musella, A., Sacchetti, L., Cantarella, C., Castelli, M., Cavasinni, F., Motta, C., Studer, V., Bernardi, G., et al. (2010) · Molecular Pharmacology

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 82

The endocannabinoid hydrolysis inhibitor SA-57: intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice

Wilkerson, J. L., Ghosh, S., Mustafa, M., Abdullah, R. A., Niphakis, M. J., Cabrera, R., Maldonado, R. L., Cravatt, B. F., & Lichtman, A. H. (2017) · Neuropharmacology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 78

Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex

Zaro, B. W., Vinogradova, E. V., Lazar, D. C., Blewett, M. M., Suciu, R. M., Takaya, J., Studer, S., de la Torre, J. C., Casanova, J.-L., Cravatt, B. F., et al. (2019) · The Journal of Immunology

Immune Response and InflammationNF-κB Signaling Pathways

Cited by 68

Assigning functionality to cysteines by base editing of cancer dependency genes

Li, H., Ma, T., Remsberg, J. R., Won, S. J., DeMeester, K. E., Njomen, E., Ogasawara, D., Zhao, K. T., Huang, T. P., Lu, B., et al. (2023) · Nature Chemical Biology

Click Chemistry and ApplicationsProtein Degradation and Inhibitors

Cited by 62

An in vivo multiplexed small-molecule screening platform

Grüner, B. M., Schulze, C. J., Yang, D., Ogasawara, D., Dix, M. M., Rogers, Z. N., Chuang, C.-H., McFarland, C. D., Chiou, S.-H., Brown, J. M., et al. (2016) · Nature Methods

Cancer Cells and MetastasisSingle-cell and spatial transcriptomics

Cited by 62

Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice

Ghosh, S., Kinsey, S. G., Liu, Q.-S., Hruba, L., McMahon, L. R., Grim, T. W., Merritt, C. R., Wise, L. E., Abdullah, R. A., Selley, D. E., et al. (2015) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 54

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

Ortega-Gutiérrez, S., Leung, D., Ficarro, S., Peters, E. C., & Cravatt, B. F. (2008) · PLoS ONE

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 50

Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

Grim, T. W., Ghosh, S., Hsu, K.-L., Cravatt, B. F., Kinsey, S. G., & Lichtman, A. H. (2014) · Pharmacology Biochemistry and Behavior

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 50

Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice

Schlosburg, J. E., Kinsey, S. G., Ignatowska-Jankowska, B., Ramesh, D., Abdullah, R. A., Tao, Q., Booker, L., Long, J. Z., Selley, D. E., Cravatt, B. F., et al. (2014) · The Journal of Pharmacology and Experimental Therapeutics

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 44

Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice

Gamage, T. F., Ignatowska-Jankowska, B. M., Muldoon, P. P., Cravatt, B. F., Damaj, M. I., & Lichtman, A. H. (2015) · Drug and Alcohol Dependence

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 40

A Screen for Protein–Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A

Touchette, M. H., Van Vlack, E. R., Bai, L., Kim, J., Cognetta, A. B., Previti, M. L., Backus, K. M., Martin, D. W., Cravatt, B. F., & Seeliger, J. C. (2017) · ACS Infectious Diseases

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 34

Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes

Ogasawara, D., Konrad, D. B., Tan, Z. Y., Carey, K. L., Luo, J., Won, S. J., Li, H., Carter, T. R., DeMeester, K. E., Njomen, E., et al. (2024) · Cell Chemical Biology

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 31

Robust anti‐nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain

Burston, J. J., Mapp, P. I., Sarmad, S., Barrett, D. A., Niphakis, M. J., Cravatt, B. F., Walsh, D. A., & Chapman, V. (2016) · British Journal of Pharmacology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 30

Double dissociation of monoacylglycerol lipase inhibition and CB1 antagonism in the central amygdala, basolateral amygdala, and the interoceptive insular cortex on the affective properties of acute naloxone-precipitated morphine withdrawal in rats

Wills, K. L., Petrie, G. N., Millett, G., Limebeer, C. L., Rock, E. M., Niphakis, M. J., Cravatt, B. F., & Parker, L. A. (2016) · Neuropsychopharmacology

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 25

Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells

Jing, H., Reed, A., Ulanovskaya, O. A., Grigoleit, J.-S., Herbst, D. M., Henry, C. L., Li, H., Barbas, S., Germain, J., Masuda, K., et al. (2021) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchFatty Acid Research and Health

Cited by 24

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO

Lindsey, G. L., Hockley, T. K., Gomez, A. V., Marshall, A. C., Brothers, W. R., Finney, C. T., Gross, J., Fox, A. H., Yeo, G. W., Melillo, B., et al. (2026) · Cell Chemical Biology

RNA Research and SplicingClick Chemistry and Applications

Cited by 6

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO

Lindsey, G. L., Hockley, T. K., Gomez, A. V., Marshall, A. C., Brothers, W. R., Finney, C. T., Gross, J., Fox, A. H., Yeo, G. W., Melillo, B., et al. (2025) · Cell chemical biology

RNA Research and SplicingClick Chemistry and Applications

Cited by 6