Vallier, Ludovic

Senescence impairs successful reprogramming to pluripotent stem cells

Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 642

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., et al. (2017) · Nature

Pluripotent Stem Cells ResearchGenetic Associations and Epidemiology

Cited by 586

GDF15 mediates the effects of metformin on body weight and energy balance

Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., et al. (2020) · Nature

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 584

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., et al. (2021) · Science

Liver physiology and pathologyOrgan Transplantation Techniques and Outcomes

Cited by 394

Genome editing reveals a role for OCT4 in human embryogenesis

Fogarty, N. M. E., McCarthy, A., Snijders, K. E., Powell, B. E., Kubikova, N., Blakeley, P., Lea, R., Elder, K., Wamaitha, S. E., Kim, D., et al. (2017) · Nature

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 392

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Cuomo, A. S. E., Seaton, D. D., McCarthy, D. J., Martinez, I., Bonder, M. J., Garcia-Bernardo, J., Amatya, S., Madrigal, P., Isaacson, A., Buettner, F., et al. (2020) · Nature Communications

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 331

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

Sampaziotis, F., Justin, A. W., Tysoe, O. C., Sawiak, S., Godfrey, E. M., Upponi, S. S., Gieseck, R. L., de Brito, M. C., Berntsen, N. L., Gómez-Vázquez, M. J., et al. (2017) · Nature Medicine

Tissue Engineering and Regenerative MedicinePediatric Hepatobiliary Diseases and Treatments

Cited by 296

Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

Rouhani, F., Kumasaka, N., de Brito, M. C., Bradley, A., Vallier, L., & Gaffney, D. (2014) · PLoS Genetics

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 294

Activin/nodal signalling in stem cells

Pauklin, S., & Vallier, L. (2015) · Development

Developmental Biology and Gene RegulationTGF-β signaling in diseases

Cited by 195

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations

Iovino, M., Agathou, S., González-Rueda, A., Del Castillo Velasco-Herrera, M., Borroni, B., Alberici, A., Lynch, T., O’Dowd, S., Geti, I., Gaffney, D., et al. (2015) · Brain

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 155

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

Wesley, B. T., Ross, A. D. B., Muraro, D., Miao, Z., Saxton, S., Tomaz, R. A., Morell, C. M., Ridley, K., Zacharis, E. D., Petrus-Reurer, S., et al. (2022) · Nature Cell Biology

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 146

Acquisition of epithelial plasticity in human chronic liver disease

Gribben, C., Galanakis, V., Calderwood, A., Williams, E. C., Chazarra-Gil, R., Larraz, M., Frau, C., Puengel, T., Guillot, A., Rouhani, F. J., et al. (2024) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 142

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

Gieseck, R. L., Ramalingam, T. R., Hart, K. M., Vannella, K. M., Cantu, D. A., Lu, W.-Y., Ferreira-González, S., Forbes, S. J., Vallier, L., & Wynn, T. A. (2016) · Immunity

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 132

Variability of human pluripotent stem cell lines

Ortmann, D., & Vallier, L. (2017) · Current Opinion in Genetics & Development

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 117

Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids

Rimland, C. A., Tilson, S. G., Morell, C. M., Tomaz, R. A., Lu, W., Adams, S. E., Georgakopoulos, N., Otaizo‐Carrasquero, F., Myers, T. G., Ferdinand, J. R., et al. (2021) · Hepatology

Liver physiology and pathologyCholangiocarcinoma and Gallbladder Cancer Studies

Cited by 110

Human Embryonic Stem Cells: An In Vitro Model to Study Mechanisms Controlling Pluripotency in Early Mammalian Development

Vallier, L., & Pedersen, R. A. (2005) · Stem Cell Reviews

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 60

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Ng, N. H. J., Jasmen, J. B., Lim, C. S., Lau, H. H., Krishnan, V. G., Kadiwala, J., Kulkarni, R. N., Ræder, H., Vallier, L., Hoon, S., et al. (2019) · iScience

Pluripotent Stem Cells ResearchPancreatic function and diabetes

Cited by 54

Potential of human induced pluripotent stem cells in studies of liver disease

Sampaziotis, F., Segeritz, C., & Vallier, L. (2015) · Hepatology

Pluripotent Stem Cells ResearchDrug-Induced Hepatotoxicity and Protection

Cited by 49

Modeling Nonalcoholic Fatty Liver Disease in the Dish Using Human-Specific Platforms: Strategies and Limitations

Rezvani, M., Vallier, L., & Guillot, A. (2023) · Cellular and Molecular Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 34

Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease.

Speicher, A. M., Korn, L., Csatári, J., Gonzalez-Cano, L., Heming, M., Thomas, C., Schroeter, C. B., Schafflick, D., Li, X., Gola, L., et al. (2022) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 28

Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors

Yang, G., Si-Tayeb, K., Corbineau, S., Vernet, R., Gayon, R., Dianat, N., Martinet, C., Clay, D., Goulinet-Mainot, S., Tachdjian, G., et al. (2013) · BMC Biology

Pluripotent Stem Cells ResearchVirus-based gene therapy research

Cited by 26

Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming

Liu, H., Yin, G., Franco Leonardi, B., Lan, T., Ait Ahmed, Y., Berger, H., Kohlhepp, M. S., Amiridze, N., Martagón Calderón, N., Frau, C., et al. (2025) · Gut

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 23

Single-Cell Transcriptomic Profiling of Cholangiocyte Organoids Derived from Bile Ducts of Primary Sclerosing Cholangitis Patients

Frank, A. K., Chung, B. K., De Novales, M. L. L., Engesæter, L. K., Hoyle, H. W., Øgaard, J., Heslop, J., Karlsen, T. H., Tysoe, O., Brevini, T., et al. (2024) · Digestive Diseases and Sciences

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 14

Exploiting the plasticity of cholangiocytes to repair the biliary tree

Frau, C., & Vallier, L. (2024) · Current Opinion in Genetics & Development

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 2