Oligodendrocyte precursors migrate along vasculature in the developing nervous system
Open accessAbstract
Neuronal migrations follow vascular pathways: In the developing brain, various types of cells migrate from their birthplaces to their workplaces. Oligodendrocyte precursors, which develop to form the insulating sheaths that make signal transmission along an axon faster, travel farther than many. Tsai et al. now show just how the oligodendrocyte precursor cells find their way (see the Perspective by Dejana and Beltsholtz). The progenitor cells follow along the endothelial cells of the vasculature. Disrupting endothelial cells interfered with oligodendrocyte migration, leaving some sections of the brain deficient in insulators. Science , this issue p. 379 ; see also p. 341
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COL1A1-/PDGFRA+ OPCs are distributed in the parenchyma, in close association but not overlapping with the vasculature.
“COL1A1-/PDGFRA+ OPCs were distributed in the parenchyma, in close association but not overlapping with the vasculature”
From Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016) · cites this paper as [18]
The paper reports that PDGFRα+ OPCs associate closely with vessels during migration and describes their dispersal into CNS parenchyma (Abstract; page not provided). It does not identify the OPCs as COL1A1− or establish that they do not overlap with the vasculature; many are described as having cell bodies directly on vessel walls. (LLM, conf=0.85)
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- Authors
- Tsai, H.-H., Niu, J., Munji, R., Davalos, D., Chang, J., Zhang, H., Tien, A.-C., Kuo, C. J., Chan, J. R., Daneman, R., & Fancy, S. P. J.
- Affiliations
- University of California, San Francisco (US)
- University of California San Diego (US)
- Cleveland Clinic (US)
- Stanford Medicine (US)
- Division of Hematology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
- Corresponding author
- Tsai, Hui-Hsin
- Niu, Jianqin
- Fancy, Stephen P. J.
- ORCID
- Venue
- Science
- Published
- 2016-01-22
- Volume
- 351
- Issue
- 6271
- Pages
- 379-384
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5472053
- OpenAlex
- W2279320212
- Cited by
- 483
- References
- 40
- Citations by year
- 2026: 42 · 2025: 53 · 2024: 69 · 2023: 51 · 2022: 41 · 2021: 47 · 2020: 45 · 2019: 46 · 2018: 31 · 2017: 35 · 2016: 20
- FWCI
- 22.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California (142657)
- National Institute of Neurological Disorders and Stroke (1P01 NS083513)
- HHMI
- American Heart Association (15POST23020039)
- NIH (1R01NS064517)
- National Multiple Sclerosis Society (RG 5216-A-1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- oligodendrocyte precursor cells, cell migration, vascular system, pericytes, Wnt signaling, CXCR4, chemokine signaling, myelination, brain development, spinal cord development, human cortex, OPC differentiation
- MeSH terms
- Animals, Blood Vessels, Cell Movement, Cerebral Cortex, Endothelium, Vascular, Humans, Oligodendroglia, Spinal Cord, Signal Transduction, Receptors, CXCR4, Pericytes, Organogenesis, Wnt Proteins, Mice, Neurogenesis, Neural Stem Cells
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