Brüne, Bernhard

Nrf2, the Master Regulator of Anti-Oxidative Responses

Vomund, S., Schäfer, A., Parnham, M., Brüne, B., & Von Knethen, A. (2017) · International Journal of Molecular Sciences

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 752

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

Dorsheimer, L., Assmus, B., Rasper, T., Ortmann, C. A., Ecke, A., Abou-El-Ardat, K., Schmid, T., Brüne, B., Wagner, S., Serve, H., et al. (2019) · JAMA Cardiology

Acute Myeloid Leukemia ResearchBlood disorders and treatments

Cited by 470

Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

Metzen, E., Zhou, J., Jelkmann, W., Fandrey, J., & Brüne, B. (2003) · Molecular Biology of the Cell

Cancer, Hypoxia, and MetabolismNitric Oxide and Endothelin Effects

Cited by 414

Redox control of inflammation in macrophages

Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A. (2013) · Antioxidants & Redox Signaling

Redox biology and oxidative stressImmune cells in cancer

Cited by 377

Iron as a central player and promising target in cancer progression

Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 268

MicroRNA-27b Contributes to Lipopolysaccharide-mediated Peroxisome Proliferator-activated Receptor γ (PPARγ) mRNA Destabilization

Jennewein, C., von Knethen, A., Schmid, T., & Brüne, B. (2010) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsMicroRNA in disease regulation

Cited by 183

Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

Zhou, J., Schmid, T., & Brüne, B. (2003) · Molecular Biology of the Cell

Cancer, Hypoxia, and MetabolismNF-κB Signaling Pathways

Cited by 177

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity

Tausendschön, M., Dehne, N., & Brüne, B. (2011) · Cytokine

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 132

Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses

Farin, H. F., Mosa, M. H., Ndreshkjana, B., Grebbin, B. M., Ritter, B., Menche, C., Kennel, K. B., Ziegler, P. K., Szabó, L., Bollrath, J., et al. (2023) · Cancer Discovery

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 120

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

Jung, M., Ören, B., Mora, J., Mertens, C., Dziumbla, S., Popp, R., Weigert, A., Grossmann, N., Fleming, I., & Brüne, B. (2016) · Science Signaling

Lymphatic System and DiseasesSphingolipid Metabolism and Signaling

Cited by 87

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment

Mertens, C., Mora, J., Ören, B., Grein, S., Winslow, S., Scholich, K., Weigert, A., Malmström, P., Forsare, C., Fernö, M., et al. (2018) · OncoImmunology

Immune cells in cancerIron Metabolism and Disorders

Cited by 85

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression

Mertens, C., Akam, E. A., Rehwald, C., Brüne, B., Tomat, E., & Jung, M. (2016) · PLOS ONE

Immune cells in cancerIron Metabolism and Disorders

Cited by 83

Transcription factors p53 and HIF-1α as targets of nitric oxide

Brüne, B., von Knethen, A., & Sandau, K. B. (2001) · Cellular Signalling

Nitric Oxide and Endothelin EffectsCancer, Hypoxia, and Metabolism

Cited by 68

Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10

Tausendschön, M., Rehli, M., Dehne, N., Schmidl, C., Döring, C., Hansmann, M.-L., & Brüne, B. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 43

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

Schmid, T., Bajer, M. M., Blees, J. S., Eifler, L. K., Milke, L., Rübsamen, D., Schulz, K., Weigert, A., Baker, A. R., Colburn, N. H., et al. (2011) · Carcinogenesis

Immune cells in cancerCancer-related Molecular Pathways

Cited by 39

Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4

Schmid, T., Blees, J. S., Bajer, M. M., Wild, J., Pescatori, L., Cuzzucoli Crucitti, G., Scipione, L., Costi, R., Henrich, C. J., Brüne, B., et al. (2016) · PLOS ONE

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 10