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Cited by 752Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysRedox biology and oxidative stress

Nrf2, the Master Regulator of Anti-Oxidative Responses

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Vomund, Sandra, Schäfer, Anne, Parnham, Michael, Brüne, Bernhard, Von Knethen, Andreas·2017·International Journal of Molecular Sciences
DOI 10.3390/ijms18122772PMC PMC5751370
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Abstract

Tight regulation of inflammation is very important to guarantee a balanced immune response without developing chronic inflammation. One of the major mediators of the resolution of inflammation is the transcription factor: the nuclear factor erythroid 2-like 2 (Nrf2). Stabilized following oxidative stress, Nrf2 induces the expression of antioxidants as well as cytoprotective genes, which provoke an anti-inflammatory expression profile, and is crucial for the initiation of healing. In view of this fundamental modulatory role, it is clear that both hyper- or hypoactivation of Nrf2 contribute to the onset of chronic diseases. Understanding the tight regulation of Nrf2 expression/activation and its interaction with signaling pathways, known to affect inflammatory processes, will facilitate development of therapeutic approaches to prevent Nrf2 dysregulation and ameliorate chronic inflammatory diseases. We discuss in this review the principle mechanisms of Nrf2 regulation with a focus on inflammation and autophagy, extending the role of dysregulated Nrf2 to chronic diseases and tumor development.

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Cited by

Sorted by citations

Authors
Vomund, S., Schäfer, A., Parnham, M., Brüne, B., & Von Knethen, A.
Affiliations
  • Fraunhofer Institute for Molecular Biology and Applied Ecology (DE)
  • Goethe University Frankfurt (DE)
  • Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-12-20
Volume
18
Issue
12
Pages
2772
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms18122772
PMC
PMC5751370
OpenAlex
W2779339038
Cited by
752
References
19
Citations by year
2026: 94 · 2025: 84 · 2024: 115 · 2023: 92 · 2022: 95 · 2021: 106 · 2020: 92 · 2019: 56 · 2018: 17
FWCI
4.27
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion, other-oa)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
  • Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
Funders
  • Spinal Muscular Atrophy Foundation
  • Deutsche Forschungsgemeinschaft (SFB 815, KN493/9-2)
  • Else Kröner-Fresenius-Stiftung (SFB815)
  • Institut National d'assurance Maladie-Invalidité
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
Nrf2, oxidative stress, antioxidant response, inflammation, chronic inflammation, autophagy, transcription factor regulation, chronic disease, carcinogenesis, cytoprotective genes, inflammation resolution
MeSH terms
Animals, Antioxidants, Autophagy, Humans, Mitochondria, Oxidative Stress, NF-E2-Related Factor 2

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