Wharton, Stephen B.

Age, Neuropathology, and Dementia

Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 900

White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 587

Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy

Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 532

Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe Consortium

Alafuzoff, I., Arzberger, T., Al‐Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del‐Tredici, K., Ferrer, I., Gelpi, E., et al. (2008) · Brain Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 467

A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

Matthews, F. E., Stephan, B. C. M., Robinson, L., Jagger, C., Barnes, L. E., Arthur, A., Brayne, C., Cognitive Function and Ageing Studies (CFAS) Collaboration, Comas-Herrera, A., Wittenberg, R., et al. (2016) · Nature Communications

Dementia and Cognitive Impairment ResearchCognitive Abilities and Testing

Cited by 426

Astrocyte phenotype in relation to Alzheimer‐type pathology in the ageing brain

Simpson, J. E., Ince, P. G., Lace, G., Forster, G., Shaw, P. J., Matthews, F., Savva, G., Brayne, C., & Wharton, S. B. (2010) · Neurobiology of Aging

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 381

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

Matthews, F. E., Brayne, C., Lowe, J., McKeith, I., Wharton, S. B., & Ince, P. (2009) · PLoS Medicine

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 279

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

Cox, L. E., Ferraiuolo, L., Goodall, E. F., Heath, P. R., Higginbottom, A., Mortiboys, H., Hollinger, H. C., Hartley, J. A., Brockington, A., Burness, C. E., et al. (2010) · PLoS ONE

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 262

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 233

White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses

Simpson, J. E., Fernando, M. S., Clark, L., Ince, P. G., Matthews, F., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., Brayne, C., et al. (2007) · Neuropathology and Applied Neurobiology

Neuroinflammation and Neurodegeneration MechanismsCerebrovascular and genetic disorders

Cited by 215

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

Hill, R. M., Kuijper, S., Lindsey, J. C., Petrie, K., Schwalbe, E. C., Barker, K., Boult, J. K. R., Williamson, D., Ahmad, Z., Hallsworth, A., et al. (2015) · Cancer Cell

Glioma Diagnosis and TreatmentCancer-related Molecular Pathways

Cited by 210

Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

Alafuzoff, I., Thal, D. R., Arzberger, T., Bogdanovic, N., Al-Sarraj, S., Bodi, I., Boluda, S., Bugiani, O., Duyckaerts, C., Gelpi, E., et al. (2009) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 193

The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia

Nichols, E., Merrick, R., Hay, S. I., Himali, D., Himali, J. J., Hunter, S., Keage, H. A. D., Latimer, C. S., Scott, M. R., Steinmetz, J. D., et al. (2023) · The Lancet Healthy Longevity

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 108

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain

Growth Hormone and Insulin-like Growth FactorsAlzheimer's disease research and treatments

Cited by 101

Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development

Williamson, D., Schwalbe, E. C., Hicks, D., Aldinger, K. A., Lindsey, J. C., Crosier, S., Richardson, S., Goddard, J., Hill, R. M., Castle, J., et al. (2022) · Cell Reports

Glioma Diagnosis and TreatmentNeuroblastoma Research and Treatments

Cited by 87

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

Al‐Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., Brayne, C., Ince, P. G., Wharton, S. B., & Medical Research Council Cognitive Function and Ageing Study (2015) · Brain Pathology

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 85

Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain

Simpson, J. E., Wharton, S. B., Cooper, J., Gelsthorpe, C., Baxter, L., Forster, G., Shaw, P. J., Savva, G., Matthews, F. E., Brayne, C., et al. (2010) · Neuroscience Letters

Barrier Structure and Function StudiesCerebrovascular and genetic disorders

Cited by 77

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Xia, Z., Prescott, E. E., Urbanek, A., Wareing, H. E., King, M. C., Olerinyova, A., Dakin, H., Leah, T., Barnes, K. A., Matuszyk, M. M., et al. (2024) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 67

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., Ratcliffe, L. E., Morgan, S., Heath, P. R., Shaw, P. J., et al. (2015) · Neuroscience Letters

FOXO transcription factor regulationAlzheimer's disease research and treatments

Cited by 66

The need to unify neuropathological assessments of vascular alterations in the ageing brain

Alafuzoff, I., Gelpi, E., Al-Sarraj, S., Arzberger, T., Attems, J., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Englund, E., et al. (2012) · Experimental Gerontology

Neurological Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 65

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., Garwood, C., Higginbottom, A., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · Neuropathology and Applied Neurobiology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 56

Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort

Lace, G., Ince, P. G., Brayne, C., Savva, G. M., Matthews, F. E., de Silva, R., Simpson, J. E., & Wharton, S. B. (2012) · Dementia and Geriatric Cognitive Disorders

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 52

Calcium dysregulation in relation to Alzheimer‐type pathology in the ageing brain

Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., Baxter, L., Gelsthorpe, C., Forster, G., Matthews, F. E., et al. (2013) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsCalpain Protease Function and Regulation

Cited by 47