Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
Open accessAbstract
beta-Amyloid (A-beta) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes are not convincing. It has been recently proposed in the same way as iota and alpha synuclein related lesions, also A-beta related pathology may follow a temporal evolution, i.e. distinct phases, characterized by a step-wise involvement of different brain-regions. Twenty-six independent observers reached an 81% absolute agreement while assessing the phase of A-beta, i.e. phase 1 = deposition of A-beta exclusively in neocortex, phase 2 = additionally in allocortex, phase 3 = additionally in diencephalon, phase 4 = additionally in brainstem, and phase 5 = additionally in cerebellum. These high agreement rates were reached when at least six brain regions were evaluated. Likewise, a high agreement (93%) was reached while assessing the absence/presence of cerebral amyloid angiopathy (CAA) and the type of CAA (74%) while examining the six brain regions. Of note, most of observers failed to detect capillary CAA when it was only mild and focal and thus instead of type 1, type 2 CAA was diagnosed. In conclusion, a reliable assessment of A-beta phase and presence/absence of CAA was achieved by a total of 26 observers who examined a standardized set of blocks taken from only six anatomical regions, applying commercially available reagents and by assessing them as instructed. Thus, one may consider rating of A-beta-phases as a diagnostic tool while analyzing subjects with suspected Alzheimer's disease (AD). Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies.
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Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Self-citationBraak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Self-citationAlzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693 · see citing works
Neuropathology of Cognitively Normal Elderly
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works
Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study
Vonsattel, J. P. G., Myers, R. H., Tessa Hedley‐Whyte, E., Ropper, A. H., Bird, E. D., & Richardson, E. P. (1991) · Annals of Neurology · doi:10.1002/ana.410300503 · Cited by 662 · see citing works
Alafuzoff, I., Arzberger, T., Al‐Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del‐Tredici, K., Ferrer, I., Gelpi, E., et al. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00147.x · Cited by 467 · see citing works
Self-citationTwo Types of Sporadic Cerebral Amyloid Angiopathy
Thal, D. R., Ghebremedhin, E., Rüb, U., Yamaguchi, H., Del Tredici, K., & Braak, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.3.282 · Cited by 446 · see citing works
Self-citationKlunk, W. E., Price, J. C., Mathis, C. A., Tsopelas, N. D., Lopresti, B. J., Ziolko, S. K., Bi, W., Hoge, J. A., Cohen, A. D., Ikonomovic, M. D., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-07.2007 · Cited by 389 · see citing works
Mackenzie, I. R., Baborie, A., Pickering-Brown, S. M., du Plessis, D., Jaros, E., Perry, R. H., Neary, D., Snowden, J. S., & Mann, D. M. A. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0138-9 · Cited by 322 · see citing works
Sampathu, D. M., Neumann, M., Kwong, L. K., Chou, T. T. T., Micsenyi, M. C., Truax, A. C., BRUCE, J. S., Grossman, M., Trojanowski, J. Q., & Lee, V. M. ‐. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060438 · Cited by 317 · see citing works
Cerebral Amyloid Angiopathies: A Pathologic, Biochemical, and Genetic View
Révész, T., Ghiso, J. A., Lashley, T., Plant, G. T., Rostagno, A. A., Frangione, B., & Holton, J. L. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.9.885 · Cited by 286 · see citing works
Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology?a pilot study
Attems, J., & Jellinger, K. A. (2004) · Acta Neuropathologica · doi:10.1007/s00401-003-0796-9 · Cited by 179 · see citing works
Leverenz, J. B., Hamilton, R. L., Tsuang, D. W., Schantz, A. M., Vavrek, D. A., Larson, E. B., Kukull, W. A., López, O. L., Galasko, D. R., Masliah, E., et al. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00117.x · Cited by 152 · see citing works
Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?
Jellinger, K. A., & Attems, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0088-2 · Cited by 152 · see citing works
Striatal β-Amyloid Deposition in Parkinson Disease With Dementia
Kalaitzakis, M. E., Graeber, M. B., Gentleman, S. M., & Pearce, R. K. B. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31816362aa · Cited by 139 · see citing works
Self-citationThal, D. R., Capetillo-Zarate, E., Larionov, S., Staufenbiel, M., Zurbruegg, S., & Beckmann, N. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.017 · Cited by 138 · see citing works
Self-citationKoivunen, J., Verkkoniemi, A., Aalto, S., Paetau, A. E., Ahonen, J.-P., Viitanen, M. H., Någren, K., Rokka, J., Haaparanta‐Solin, M., Kalimo, H., et al. (2008) · Brain · doi:10.1093/brain/awn107 · Cited by 117 · see citing works
Alafuzoff, I. I., Pikkarainen, M., Arzberger, T., Thal, D. R., Al‐Sarraj, S., Bell, J. E., Bódi, I., Budka, H., Capetillo‐Zarate, E., Ferrer, I., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0358-2 · Cited by 105 · see citing works
Self-citationβ‐Amyloid deposition in brains of subjects with diabetes
Alafuzoff, I. I., Aho, L., Helisalmi, S., Mannermaa, A., & Soininen, H. S. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00948.x · Cited by 103 · see citing works
Self-citationMüller, C. M., de Vos, R. A. I., Maurage, C., Thal, D. R., Tolnay, M., & Braak, H. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000171652.40083.15 · Cited by 94 · see citing works
Self-citationUnexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy
Attems, J., Lauda, F., & Jellinger, K. A. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0674-4 · Cited by 87 · see citing works
Widespread and abundant α‐synuclein pathology in a neurologically unimpaired subject
Parkkinen, L., Pirttilä, T., Tervahauta, M., & Alafuzoff, I. I. (2005) · Neuropathology · doi:10.1111/j.1440-1789.2005.00644.x · Cited by 74 · see citing works
Self-citationSelkoe, D. J. (1989) · Annals of Medicine · doi:10.3109/07853898909149187 · Cited by 66 · see citing works
Irina, A., Seppo, H., Arto, M., Paavo, R., & Hilkka, S. (1999) · Stroke · doi:10.1161/01.str.30.3.613 · Cited by 58 · see citing works
β-Amyloid Aggregation in Human Brains With Cerebrovascular Lesions
Aho, L., Jolkkonen, J., & Alafuzoff, I. (2006) · Stroke · doi:10.1161/01.str.0000248777.44128.93 · Cited by 40 · see citing works
Self-citationJeynes, B., & Provias, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0099-z · Cited by 31 · see citing works
The load and distribution of β-amyloid in brain tissue of patients with Alzheimer's disease
Kraszpulski, M., Soininen, H. S., Helisalmi, S., & Alafuzoff, I. I. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103002088.x · Cited by 27 · see citing works
Self-citationSystematic Appraisal Using Immunohistochemistry of Brain Pathology in Aged and Demented Subjects
Aho, L., Parkkinen, L., Pirttilä, T., & Alafuzoff, I. I. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000122963 · Cited by 26 · see citing works
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Sorted by citations
The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citationMontine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · see citing works
“While we do not propose specific protocols, our recommendations are compatible with conclusions by others who have optimized reproducibility of some neuropathologic assessments across multiple sites [2–5, 41].”
Self-citationPathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665 · see citing works
The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540 · see citing works
Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy
Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1509-x · Cited by 532 · see citing works
Self-citationVascular pathology in the aged human brain
Grinberg, L. T., & Thal, D. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0652-7 · Cited by 345 · see citing works
Self-citationMurray, M. E., Lowe, V. J., Graff-Radford, N. R., Liesinger, A. M., Cannon, A., Przybelski, S. A., Rawal, B., Parisi, J. E., Petersen, R. C., Kantarci, K., et al. (2015) · Brain · doi:10.1093/brain/awv050 · Cited by 324 · see citing works
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Yin, C., Ackermann, S., Ma, Z., Mohanta, S. K., Zhang, C., Li, Y., Nietzsche, S., Westermann, M., Peng, L., Hu, D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0336-8 · Cited by 305 · see citing works
Self-citationCerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
Schoonenboom, N. S. M., Reesink, F. E., Verwey, N. A., Kester, M. I., Teunissen, C. E., van de Ven, P. M., Pijnenburg, Y. A. L., Blankenstein, M. A., Rozemuller, A. J., Scheltens, P., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31823ed0f0 · Cited by 302 · see citing works
Ihara, M., Polvikoski, T. M., Hall, R., Slade, J. Y., Perry, R. H., Oakley, A. E., Englund, E. M., O'Brien, J. T., Ince, P. G., & Kalaria, R. N. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0635-8 · Cited by 242 · see citing works
Self-citationWalker, L., McAleese, K. E., Thomas, A. J., Johnson, M. A., Martin-Ruiz, C. M., Parker, C., Colloby, S. J., Jellinger, K. A., & Attems, J. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1406-3 · Cited by 222 · see citing works
Altered Proteins in the Aging Brain
Elobeid, A., Libard, S., Leino, M., Popova, S. N., & Alafuzoff, I. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw002 · Cited by 202 · see citing works
Self-citationNelson, P. T., Brayne, C., Flanagan, M. E., Abner, E. L., Agrawal, S., Attems, J., Castellani, R. J., Corrada, M. M., Cykowski, M. D., Di, J., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02444-1 · Cited by 177 · see citing works
Self-citationStage‐dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease
Dijkstra, A. A., Voorn, P., Berendse, H. W., Groenewegen, H. J., Bank, N. B., Rozemüller, A. J. M., & van de Berg, W. D. J. (2014) · Movement Disorders · doi:10.1002/mds.25952 · Cited by 173 · see citing works
Mundiñano, I.-C., Caballero, M. C., Ordóñez, C., Hernández, M., DiCaudo, C., Marcilla, I., Erro, M. E., Tuñon, M.-T., & Luquín, M. R. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0830-2 · Cited by 171 · see citing works
Dijkstra, A. A., Ingrassia, A., de Menezes, R. X., van Kesteren, R. E., Rozemuller, A. J. M., Heutink, P., & van de Berg, W. D. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128651 · Cited by 167 · see citing works
Lattanzio, F., Abu‐Rumeileh, S., Franceschini, A., Kai, H., Amore, G., Poggiolini, I., Rossi, M., Baiardi, S., McGuire, L. I., Ladogana, A., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1683-0 · Cited by 163 · see citing works
Self-citationThal, D. R., Beach, T. G., Zanette, M., Heurling, K., Chakrabarty, A., Ismail, A., Smith, A. P. L., & Buckley, C. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.018 · Cited by 159 · see citing works
Self-citationCastillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17999-3 · Cited by 158 · see citing works
Distribution and Load of Amyloid-β Pathology in Parkinson Disease and Dementia with Lewy Bodies
Hepp, D. H., Vergoossen, D. L. E., Huisman, E., Lemstra, A. W., Bank, N. B., Berendse, H. W., Rozemüller, A. J. M., Foncke, E. M. J., & van de Berg, W. D. J. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw070 · Cited by 155 · see citing works
Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease
Balasa, M., Gelpí, E., Antonell, A., Rey, M. J., Sánchez‐Valle, R., Molinuevo, J. L., & Lladó, A. (2011) · Neurology · doi:10.1212/wnl.0b013e31821a44dd · Cited by 154 · see citing works
Šalković‐Petrišić, M., Barilar, J. O., Brückner, M. K., Hoyer, S., Arendt, T., & Riederer, P. F. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0651-4 · Cited by 136 · see citing works
Li, T., Vandesquille, M., Koukouli, F., Dudeffant, C., Youssef, I., Lenormand, P., Ganneau, C., Maskos, U., Czech, C., Grueninger, F., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.019 · Cited by 133 · see citing works
Self-citationBraak, H., & Tredici, K. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a023630 · Cited by 129 · see citing works
Epidemiological Neuropathology: The MRC Cognitive Function and Aging Study Experience
Wharton, S. B., Brayne, C., Savva, G. M., Matthews, F. E., Forster, G., Simpson, J. E., Lace, G., & Ince, P. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-091402 · Cited by 124 · see citing works
Self-citationCalderón‐Garcidueñas, A. L., & Duyckaerts, C. J. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00023-7 · Cited by 120 · see citing works
Self-citationCooper, G. J. S. (2011) · Drugs · doi:10.2165/11591370-000000000-00000 · Cited by 113 · see citing works
Dura mater is a potential source of Aβ seeds
Kovács, G. G., Lutz, M. I., Ricken, G., Ströbel, T., Höftberger, R., Preusser, M., Regelsberger, G., Hönigschnabl, S., Reiner, A., Fischer, P. A., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1565-x · Cited by 110 · see citing works
Self-citationLeinonen, V., Koivisto, A. M., Savolainen, S., Rummukainen, J., Sutela, A., Vanninen, R. L., Jääskeläinen, J. E., Soininen, H. S., & Alafuzoff, I. I. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01195.x · Cited by 99 · see citing works
Self-citationBrain banking for neurological disorders
Samarasekera, N., Salman, R. A., Huitinga, I., Klioueva, N. M., McLean, C., Kretzschmar, H. A., Smith, C., & Ironside, J. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70202-3 · Cited by 96 · see citing works
Self-citationAccuracy of Clinical Diagnosis of Dementia with Lewy Bodies versus Neuropathology
Skogseth, R. E., Hortobágyi, T., Soennesyn, H., Chwiszczuk, L. J., Ffytche, D. H., Rongve, A., Ballard, C. G., & Aarsland, D. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170274 · Cited by 94 · see citing works
Copathology in Progressive Supranuclear Palsy: Does It Matter?
Ječmenica‐Lukić, M., Kurz, C., Respondek, G., Grau‐Rivera, O., Compta, Y., Gelpí, E., Troakes, C., Barcelona Brain Bank collaborative group, T. M. P. S. G., Swieten, J. C. V., Giese, A., et al. (2020) · Movement Disorders · doi:10.1002/mds.28011 · Cited by 91 · see citing works
Self-citationTau, prions and Aβ: the triad of neurodegeneration
Reiniger, L., Lukić, A., Linehan, J. M., Rudge, P., Collinge, J., Mead, S., & Brandner, S. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0691-0 · Cited by 91 · see citing works
Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease
Hunter, S., & Brayne, C. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.218 · Cited by 94 · see citing works
Manousopoulou, A., Gatherer, M., Smith, C., Nicoll, J. A. R., Woelk, C. H., Johnson, M., Kalaria, R. N., Attems, J., Garbis, S. D., & Carare, R. O. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12342 · Cited by 87 · see citing works
How golden is the gold standard of neuropathology in dementia?
Scheltens, P., & Rockwood, K. J. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.04.011 · Cited by 84 · see citing works
String Vessel Formation is Increased in the Brain of Parkinson Disease
Yang, P., Pavlovic, D., Waldvogel, H. J., Dragunow, M., Synek, B. J., Turner, C. P., Faull, R. L. M., & Guan, J. (2015) · Journal of Parkinson s Disease · doi:10.3233/jpd-140454 · Cited by 77 · see citing works
Sugarman, M. A., McKee, A. C., Stein, T. D., Tripodis, Y., Besser, L. M., Martin, B. M., Palmisano, J. N., Steinberg, E. G., O’Connor, M. K., Au, R., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.12.015 · Cited by 75 · see citing works
Characteristics of Dyshoric Capillary Cerebral Amyloid Angiopathy
Richard, E., Carrano, A., Hoozemans, J. J., van Horssen, J., van Haastert, E. S., Eurelings, L. S., de Vries, H. E., Thal, D. R., Eikelenboom, P., van Gool, W. A., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181fab558 · Cited by 71 · see citing works
Self-citationRyan, N. S., Biessels, G. J., Kim, L. G., Nicholas, J. M., Barber, P. A., Walsh, P., Gami‐Patel, P., Morris, H. R., de Bastos-Leite, A. J., Schott, J. M., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.026 · Cited by 71 · see citing works
Sleep disorders in neurodegenerative diseases
Raggi, A., & Ferri, R. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03034.x · Cited by 68 · see citing works
Gilvesy, A., Husén, E., Maglóczky, Z., Mihály, O. S., Hortobágyi, T., Kanatani, S., Heinsen, H., Renier, N., Hökfelt, T. G. M., Mulder, J., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02477-6 · Cited by 68 · see citing works
Self-citationFujishiro, H., Iseki, E., Higashi, S., Kasanuki, K., Murayama, N., Togo, T., Katsuse, O., Uchikado, H., Aoki, N., Kosaka, K., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.036 · Cited by 67 · see citing works
The need to unify neuropathological assessments of vascular alterations in the ageing brain
Alafuzoff, I., Gelpi, E., Al-Sarraj, S., Arzberger, T., Attems, J., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Englund, E., et al. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.06.001 · Cited by 65 · see citing works
Self-citationTredici, K. D., & Braak, H. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.008 · Cited by 65 · see citing works
Reuck, J. D., Deramecourt, V., Cordonnier, C., Leys, D., Maurage, C., & Pasquier, F. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03329.x · Cited by 63 · see citing works
Selvackadunco, S., Langford, K., Shah, Z., Hurley, S. M., Bódi, I., King, A., Aarsland, D., Troakes, C., & Al‐Sarraj, S. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-018-01967-w · Cited by 58 · see citing works
Self-citationAdvances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future
Shakir, M., & Dugger, B. N. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab122 · Cited by 56 · see citing works
Prenatal high‐fat diet alters the cerebrovasculature and clearance of β‐amyloid in adult offspring
Hawkes, C. A., Gentleman, S., Nicoll, J. A. R., & Carare, R. O. (2014) · The Journal of Pathology · doi:10.1002/path.4468 · Cited by 55 · see citing works
Self-citationEl‐Obeid, A., Laurell, K., Cesarini, K. G., & Alafuzoff, I. I. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000191 · Cited by 55 · see citing works
Self-citationThal, D. R., Beach, T. G., Zanette, M., Lilja, J., Heurling, K., Chakrabarty, A., Ismail, A., Farrar, G., Buckley, C. J., & Smith, A. P. L. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1897-9 · Cited by 55 · see citing works
Self-citationMultisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)
Kovács, G. G., Xie, S. X., Lee, E. B., Robinson, J. L., Caswell, C., Irwin, D. J., Toledo, J. B., Johnson, V. E., Smith, D. H., Alafuzoff, I. I., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx041 · Cited by 54 · see citing works
Self-citationBaiardi, S., Abu‐Rumeileh, S., Rossi, M., Zenesini, C., Bartoletti‐Stella, A., Polischi, B., Capellari, S., & Parchi, P. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.697 · Cited by 53 · see citing works
Self-citationVikartovská, Z., Farbáková, J., Smolek, T., Hanes, J., Žilka, N., Horňáková, Ľ., Humeník, F., Maloveská, M., Hudáková, N., & Cizkova, D. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.551895 · Cited by 52 · see citing works
Bencze, J., Szarka, M., Kóti, B., Seo, W., Hortobágyi, T. G., Bencs, V., Módis, L., & Hortobágyi, T. (2021) · Biomolecules · doi:10.3390/biom12010019 · Cited by 50 · see citing works
Characteristics of the tissue section that influence the staining outcome in immunohistochemistry
Libard, S., Cerjan, D., & Alafuzoff, I. I. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1742-1 · Cited by 50 · see citing works
Self-citationTsai, C., Liang, C., Lee, J., Su, M., Lin, C., Chu, H., Tsai, C., Lin, G., Lin, Y., & Yang, F. (2019) · Journal of Clinical Medicine · doi:10.2139/ssrn.3464407 · Cited by 48 · see citing works
Jonkman, L. E., Graaf, Y. G.-D., Bulk, M., Kaai, E., Pouwels, P. J. W., Barkhof, F., Rozemüller, A. J. M., van der Weerd, L., Geurts, J. J. G., & van de Berg, W. D. J. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101698 · Cited by 44 · see citing works
Thal, D. R., Ronisz, A., Tousseyn, T., Upadhaya, A. R., Balakrishnan, K., Vandenberghe, R. R., Vandenbulcke, M., Arnim, C. A. F. V., Otto, M., Beach, T. G., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0837-9 · Cited by 43 · see citing works
Self-citationFrigerio, I., Bouwman, M. M. A., Noordermeer, R. T. G. M. M., Podobnik, E., Popovic, M. M., Timmermans, E., Rozemüller, A. J. M., van de Berg, W. D. J., & Jonkman, L. E. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01711-w · Cited by 42 · see citing works
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Vromen, E. M., de Boer, S. C. M., Teunissen, C. E., Rozemüller, A. J. M., Sieben, A., Bjerke, M., Initiative, A. D. N., Visser, P. J., Bouwman, F. H., Engelborghs, S., et al. (2022) · Brain · doi:10.1093/brain/awac158 · Cited by 42 · see citing works
Frigerio, I., Boon, B. D. C., Lin, C., Graaf, Y. G.-D., Bol, J. G. J. M., Preziosa, P., Twisk, J. W. R., Barkhof, F., Hoozemans, J. J. M., Bouwman, F. H., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab281 · Cited by 37 · see citing works
Navarro, P. P., Genoud, C., Castaño‐Díez, D., Graff-Meyer, A., Lewis, A. J., de Gier, Y., Lauer, M. E., Britschgi, M., Bohrmann, B., Frank, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-36223-4 · Cited by 38 · see citing works
Nelson, P. T., Kukull, W. A., & Frosch, M. P. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d8db07 · Cited by 37 · see citing works
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Bigio, E. H. (2013) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2012-0075-ra · Cited by 36 · see citing works
Mundiñano, I.-C., Hernández, M., DiCaudo, C., Ordóñez, C., Marcilla, I., Tuñón, M. J., & Luquín, M. R. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1144-3 · Cited by 36 · see citing works
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Beach, T. G. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac030 · Cited by 35 · see citing works
Abu‐Rumeileh, S., Capellari, S., & Parchi, P. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171181 · Cited by 34 · see citing works
Self-citationFrigerio, I., Laansma, M. A., Lin, C., Hermans, E. J. M., Bouwman, M. M. A., Bol, J. G. J. M., Graaf, Y. G.-D., Hepp, D. H., Rozemüller, A. J. M., Barkhof, F., et al. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-022-00328-8 · Cited by 34 · see citing works
Regional differences in gene expression and promoter usage in aged human brains
Pardo, L. M., Rizzu, P., Francescatto, M., Vitezic, M., Leday, G. G. R., Sanchez, J. S., Khamis, A. M., Takahashi, H., van de Berg, W. D. J., Medvedeva, Y. A., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.005 · Cited by 34 · see citing works
Alafuzoff, I. I., Pikkarainen, M., Neumann, M., Arzberger, T., Al‐Sarraj, S., Bódi, I., Bogdanović, N., Bugiani, O., Ferrer, I., Gelpí, E., et al. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1304-1 · Cited by 32 · see citing works
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Ječmenica‐Lukić, M., Respondek, G., Kurz, C., Compta, Y., Gelpí, E., Ferguson, L. W., Rajput, A. H., Troakes, C., the MDS‐endorsed PSP study group, Swieten, J. C. V., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26455 · Cited by 31 · see citing works
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Boluda, S., Toledo, J. B., Irwin, D. J., Raible, K. M., Byrne, M., Lee, E. B., Lee, V. M. ‐., & Trojanowski, J. Q. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1308-9 · Cited by 30 · see citing works
Self-citationLibard, S., & Alafuzoff, I. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0748-9 · Cited by 24 · see citing works
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Martikainen, P., Pikkarainen, M., Pöntynen, K., Hiltunen, M. O., Lehtovirta, M., Tuisku, S., Soininen, H. S., & Alafuzoff, I. I. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01046.x · Cited by 28 · see citing works
Self-citationon behalf of the Cognitive Function and Ageing Neuropathology Study Group, Wharton, S. B., Wang, D. Y. Q., Parikh, C. R., Matthews, F. E., Brayne, C., & Ince, P. G. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0858-4 · Cited by 28 · see citing works
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de Ruyter, F. J. H., Evers, M. J. A. P., Morrema, T. H. J., Dijkstra, A. A., den Haan, J., Twisk, J. W. R., de Boer, J. F., Scheltens, P., Bouwman, F. H., Verbraak, F. D., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02769-z · Cited by 27 · see citing works
TAR-DNA binding protein-43 and alterations in the hippocampus
Rauramaa, T. H., Pikkarainen, M., Englund, E. M., Ince, P. G., Jellinger, K. A., Paetau, A. E., & Alafuzoff, I. I. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-010-0574-5 · Cited by 27 · see citing works
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Fiock, K. L., Smith, J. D., Crary, J. F., & Hefti, M. M. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24741 · Cited by 27 · see citing works
Postupna, N. O., Rose, S. E., Bird, T. D., Gonzalez‐Cuyar, L. F., Sonnen, J. A., Larson, E. B., Keene, C. D., & Montine, T. J. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00542.x · Cited by 26 · see citing works
Chatterjee, M., van Steenoven, I., Huisman, E., Oosterveld, L. P., Berendse, H. W., van der Flier, W. M., del Campo, M., Lemstra, A. W., van de Berg, W. D. J., & Teunissen, C. E. (2020) · Biomolecules · doi:10.3390/biom10081177 · Cited by 25 · see citing works
Thal, D. R., Ronisz, A., Tousseyn, T., Upadhaya, A. R., Balakrishnan, K., Vandenberghe, R. R., Vandenbulcke, M., Arnim, C. A. F. V., Otto, M., Beach, T. G., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01005-5 · Cited by 25 · see citing works
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Kumar, S., Lemere, C. A., & Walter, J. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00959-w · Cited by 24 · see citing works
Chew, E. G. Y., Liu, Z., Li, Z., Chung, S. J., Lian, M. M., Tandiono, M., Heng, Y. J., Ng, E., Tan, L. C. S., Chng, W. L., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00760-7 · Cited by 23 · see citing works
Amyloid-Beta Pathology and Cognitive Performance in Centenarians
Rohde, S. K., Luimes, M. C., Lorenz, L. M. C., Fierro‐Hernández, P., Rozemüller, A. J. M., Hulsman, M., Zhang, M., Graat, M., van der Hoorn, M. E., Daatselaar, D., et al. (2025) · JAMA Neurology · doi:10.1001/jamaneurol.2025.1734 · Cited by 23 · see citing works
Rossi, M., Kai, H., Baiardi, S., Bartoletti‐Stella, A., Carlà, B., Zenesini, C., Capellari, S., Kitamoto, T., & Parchi, P. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0706-6 · Cited by 23 · see citing works
Self-citationSheikh, A. M., Yano, S., Tabassum, S., Mitaki, S., Michikawa, M., & Nagai, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054510 · Cited by 22 · see citing works
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Alafuzoff, I. I., & Libard, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074065 · Cited by 21 · see citing works
Self-citationVerwey, N. A., Hoozemans, J. J. M., Korth, C., van Royen, M. R., Prikulis, I., Wouters, D., Twaalfhoven, H. A. M., van Haastert, E. S., Schenk, D., Scheltens, P., et al. (2013) · Amyloid · doi:10.3109/13506129.2013.797389 · Cited by 21 · see citing works
Mixed Brain Pathology Is the Most Common Cause of Cognitive Impairment in the Elderly
Alafuzoff, I. I., & Libard, S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200925 · Cited by 21 · see citing works
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Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection
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Self-citationVizcarra, J. C., Pearce, T. M., Dugger, B. N., Keiser, M. J., Gearing, M., Crary, J. F., Kiely, E. J., Morris, M., White, B., Glass, J. D., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01691-x · Cited by 19 · see citing works
Amyotrophic lateral sclerosis and non-tau frontotemporal lobar degeneration
Hortobágyi, T., & Cairns, N. J. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00026-2 · Cited by 19 · see citing works
Roy, M., Cardoso, C., Dorieux, O., Malgorn, C., Epelbaum, S., Petit, F., Kraska, A., Brouillet, E., Delatour, B., Perret, M., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.017 · Cited by 18 · see citing works
Gawor, K., Verrept, S., Arekatla, G., Wouters, D., Ronisz, A., Hecht, M., Laureyssen, C., Donck, H. V., Lahaije, B., Ospitalieri, S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70483 · Cited by 17 · see citing works
Self-citationWillroider, M., Roeber, S., Horn, A. K. E., Arzberger, T., Scheifele, M., Respondek, G., Sabri, O., Barthel, H., Patt, M., Mishchenko, O., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.684523 · Cited by 16 · see citing works
Self-citationInitiative, A. D. N., Li, Y., Liu, Y., Wang, P., Wang, J., Xu, S., & Qiu, M. (2017) · BioMedical Engineering OnLine · doi:10.1186/s12938-017-0342-y · Cited by 16 · see citing works
Amyloid in skin and brain: What′s the link?
Schreml, S., Kaiser, E., Landthaler, M., Szeimies, R., & Babilas, P. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01166.x · Cited by 16 · see citing works
- Authors
- Alafuzoff, I., Thal, D. R., Arzberger, T., Bogdanovic, N., Al-Sarraj, S., Bodi, I., Boluda, S., Bugiani, O., Duyckaerts, C., Gelpi, E., Gentleman, S., Giaccone, G., Graeber, M., Hortobagyi, T., Höftberger, R., Ince, P., Ironside, J. W., Kavantzas, N., King, A., Korkolopoulou, P., Kovács, G. G., Meyronet, D., Monoranu, C., Nilsson, T., Parchi, P., Patsouris, E., Pikkarainen, M., Revesz, T., Rozemuller, A., Seilhean, D., Schulz-Schaeffer, W., Streichenberger, N., Wharton, S. B., & Kretzschmar, H.
- Affiliations
- Universität Ulm (DE)
- Institut für Neuropathologie (DE)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Pierre-et-Marie-Curie (FR)
- Imperial College London (GB)
- The Athenaeum Club (GB)
- Medical University of Vienna (AT)
- Royal Hallamshire Hospital (GB)
- Western General Hospital (GB)
- National and Kapodistrian University of Athens (GR)
- Lyon 1 Université (FR)
- University of Würzburg (DE)
- Karolinska Institutet (SE)
- University of Bologna (IT)
- University of Sheffield (GB)
- Corresponding author
- Alafuzoff, Irina
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2009-02-01
- Volume
- 117
- Issue
- 3
- Pages
- 309-320
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC2910889
- OpenAlex
- W2138638156
- Cited by
- 193
- References
- 31
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 18 · 2023: 14 · 2022: 13 · 2021: 11 · 2020: 6 · 2019: 17 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 3
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Neuropathologica (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- GRO (submittedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Parkinson's UK (G0909)
- European Commission (LSHM-CT-2004-503039)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- beta-amyloid deposits, Alzheimer's disease, cerebral amyloid angiopathy, interobserver agreement, diencephalon, brainstem, cerebellum, allocortex, neocortex
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Arteries, Female, Humans, Immunohistochemistry, Male, Middle Aged, Reference Values, Reproducibility of Results, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Disease Progression
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