Partridge, Linda

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 6,549

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 3,023

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 1,475

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 1,313

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 1,245

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,120

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,057

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 836

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 822

COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Hall, V. J., Foulkes, S., Saei, A., Andrews, N., Oguti, B., Charlett, A., Wellington, E., Stowe, J., Gillson, N., Atti, A., et al. (2021) · The Lancet

SARS-CoV-2 and COVID-19 ResearchVaccine Coverage and Hesitancy

Cited by 767

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

Mizielinska, S., Grönke, S., Niccoli, T., Ridler, C. E., Clayton, E. L., Devoy, A., Moens, T., Norona, F. E., Woollacott, I. O. C., Pietrzyk, J., et al. (2014) · Science

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 740

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 727

SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Hall, V. J., Foulkes, S., Charlett, A., Atti, A., Monk, E. J. M., Simmons, R., Wellington, E., Cole, M. J., Saei, A., Oguti, B., et al. (2021) · The Lancet

SARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studies

Cited by 638

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 624

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Chouchani, E. T., Methner, C., Nadtochiy, S. M., Logan, A., Pell, V. R., Ding, S., James, A. M., Cochemé, H. M., Reinhold, J., Lilley, K. S., et al. (2013) · Nature Medicine

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 619

A cost of mating in female fruitflies

Fowler, K., & Partridge, L. (1989) · Nature

Animal Behavior and ReproductionGenetics, Aging, and Longevity in Model Organisms

Cited by 570

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 532

The quest to slow ageing through drug discovery

Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 468

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressGenetics, Aging, and Longevity in Model Organisms

Cited by 313

Small nucleoli are a cellular hallmark of longevity

Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Späth, M., Suchiman, H. E. D., Müller, R.-U., Slagboom, P. E., et al. (2017) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

Cited by 287

Drosophila as a model for ageing

Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 273

Insulin/IGF-like signalling, the central nervous system and aging

Broughton, S., & Partridge, L. (2009) · Biochemical Journal

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 228

The Ras-Erk-ETS-signaling pathway is a drug target for longevity

Slack, C., Alic, N., Foley, A., Cabecinha, M., Hoddinott, M. P., & Partridge, L. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 224

Atlas of the aging mouse brain reveals white matter as vulnerable foci

Hahn, O., Foltz, A. G., Atkins, M., Kedir, B., Moran-Losada, P., Guldner, I. H., Munson, C., Kern, F., Pálovics, R., Lu, N., et al. (2023) · Cell

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 213