Powell, Joseph E.

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

Zhu, Z., Zhang, F., Hu, H., Bakshi, A., Robinson, M. R., Powell, J. E., Montgomery, G. W., Goddard, M. E., Wray, N. R., Visscher, P. M., et al. (2016) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 3,352

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Kasela, S., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,607

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., et al. (2021) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,607

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Ziegler, C. G. K., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., et al. (2020) · Cell

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 2,284

Defining the role of common variation in the genomic and biological architecture of adult human height

The Electronic Medical Records and Genomics (eMERGE) Consortium, Wood, A. R., The MIGen Consortium, The PAGE Consortium, Study, T. L. C., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., et al. (2014) · Nature Genetics

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 1,853

A single-cell and spatially resolved atlas of human breast cancers

Wu, S. Z., Al-Eryani, G., Roden, D. L., Junankar, S., Harvey, K., Andersson, A., Thennavan, A., Wang, C., Torpy, J. R., Bartonicek, N., et al. (2021) · Nature Genetics

Single-cell and spatial transcriptomicsBreast Cancer Treatment Studies

Cited by 1,775

Systematic identification of trans eQTLs as putative drivers of known disease associations

Westra, H.-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., Christiansen, M. W., Fairfax, B. P., Schramm, K., Powell, J. E., et al. (2013) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 1,658

The transcriptional landscape of age in human peripheral blood

Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., Reinmaa, E., Sutphin, G. L., Zhernakova, A., Schramm, K., et al. (2015) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 725

Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease

Yazar, S., Alquicira-Hernandez, J., Wing, K., Senabouth, A., Gordon, M. G., Andersen, S., Lu, Q., Rowson, A., Taylor, T. R. P., Clarke, L., et al. (2022) · Science

Genetic Associations and EpidemiologySingle-cell and spatial transcriptomics

Cited by 682

Benchmarking of cell type deconvolution pipelines for transcriptomics data

Avila Cobos, F., Alquicira-Hernandez, J., Powell, J. E., Mestdagh, P., & De Preter, K. (2020) · Nature Communications

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 446

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z., et al. (2018) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 427

Signatures of negative selection in the genetic architecture of human complex traits

Zeng, J., de Vlaming, R., Wu, Y., Robinson, M. R., Lloyd-Jones, L. R., Yengo, L., Yap, C. X., Xue, A., Sidorenko, J., McRae, A. F., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 391

Nebulosa recovers single-cell gene expression signals by kernel density estimation

Alquicira-Hernandez, J., & Powell, J. E. (2021) · Bioinformatics

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 381

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits.

Porcu, E., Rüeger, S., Lepik, K., eQTLGen Consortium, Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., et al. (2019) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 322

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation

Friedman, C. E., Nguyen, Q., Lukowski, S. W., Helfer, A., Chiu, H. S., Miklas, J., Levy, S., Suo, S., Han, J.-D. J., Osteil, P., et al. (2018) · Cell Stem Cell

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 258

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer’s disease

Furney, S. J., Simmons, A., Breen, G., Pedroso, I., Lunnon, K., Proitsi, P., Hodges, A., Powell, J., Wahlund, L.-O., Kloszewska, I., et al. (2011) · Molecular Psychiatry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 157

AAV-mediated CRISPR/cas gene editing of retinal cells in vivo

Hung, S. S. C., Chrysostomou, V., Li, F., Lim, J. K. H., Wang, J.-H., Powell, J. E., Tu, L., Daniszewski, M., Lo, C., Wong, R. C., et al. (2016) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersCRISPR and Genetic Engineering

Cited by 125

Single-cell genomics meets human genetics

Cuomo, A. S. E., Nathan, A., Raychaudhuri, S., MacArthur, D. G., & Powell, J. E. (2023) · Nature Reviews Genetics

Single-cell and spatial transcriptomicsGenetic Associations and Epidemiology

Cited by 124

Genotype-free demultiplexing of pooled single-cell RNA-seq

Xu, J., Falconer, C., Nguyen, Q., Crawford, J., McKinnon, B. D., Mortlock, S., Senabouth, A., Andersen, S., Chiu, H. S., Jiang, L., et al. (2019) · Genome Biology

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 94

Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods

Neavin, D., Senabouth, A., Arora, H., Lee, J. T. H., Ripoll-Cladellas, A., sc-eQTLGen Consortium, Franke, L., Prabhakar, S., Ye, C. J., McCarthy, D. J., et al. (2024) · Genome Biology

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 90

Demuxafy : Improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods

Neavin, D., Senabouth, A., Hang Lee, J. T., Ripoll, A., sc-eQTLGen Consortium, Franke, L., Prabhakar, S., Ye, C. J., McCarthy, D. J., Melé, M., et al. (2022) · Genome biology

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 90

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

Pinese, M., Lacaze, P., Rath, E. M., Stone, A., Brion, M.-J., Ameur, A., Nagpal, S., Puttick, C., Husson, S., Degrave, D., et al. (2020) · Nature Communications

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 70

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Kang, J. B., Shen, A. Z., Gurajala, S., Nathan, A., Rumker, L., Aguiar, V. R. C., Valencia, C., Lagattuta, K. A., Zhang, F., Jonsson, A. H., et al. (2023) · Nature Genetics

Genetic Associations and EpidemiologySingle-cell and spatial transcriptomics

Cited by 49

Endometrial vezatin and its association with endometriosis risk

Holdsworth-Carson, S. J., Fung, J. N., Luong, H. T. T., Sapkota, Y., Bowdler, L. M., Wallace, L., Teh, W. T., Powell, J. E., Girling, J. E., Healey, M., et al. (2016) · Human Reproduction

Endometriosis Research and TreatmentGenetic Associations and Epidemiology

Cited by 41