Five-year safety and performance results from the argus II retinal prosthesis system clinical trial.
Open accessAbstract
PURPOSE: The Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc, Sylmar, CA) was developed to restore some vision to patients blind as a result of retinitis pigmentosa (RP) or outer retinal degeneration. A clinical trial was initiated in 2006 to study the long-term safety and efficacy of the Argus II System in patients with bare or no light perception resulting from end-stage RP. DESIGN: Prospective, multicenter, single-arm clinical trial. Within-patient controls included the nonimplanted fellow eye and patients' native residual vision compared with their vision with the Argus II. PARTICIPANTS: Thirty participants in 10 centers in the United States and Europe. METHODS: The worse-seeing eye of blind patients was implanted with the Argus II. Patients wore glasses mounted with a small camera and a video processor that converted images into stimulation patterns sent to the electrode array on the retina. MAIN OUTCOME MEASURES: The primary outcome measures were safety (the number, seriousness, and relatedness of adverse events) and visual function, as measured by 3 computer-based, objective tests. Secondary measures included functional vision performance on objectively scored real-world tasks. RESULTS: Twenty-four of 30 patients remained implanted with functioning Argus II Systems at 5 years after implantation. Only 1 additional serious adverse event was experienced after the 3-year time point. Patients performed significantly better with the Argus II on than off on all visual function tests and functional vision tasks. CONCLUSIONS: The 5-year results of the Argus II trial support the long-term safety profile and benefit of the Argus II System for patients blind as a result of RP. The Argus II is the first and only retinal implant to have market approval in the European Economic Area, the United States, and Canada.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
At present, retinal prostheses are the most successful approach in the field of visual prostheses.
“At present, retinal prostheses are the most successful approach in this field, and several retinal devices have already been approved for patients with retinal dystrophies (Da Cruz et al., 2016; Stingl et al., 2017).”
From Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects (2020) · cites this paper as Da Cruz et al., 2016
Several retinal devices have already been approved for patients with retinal dystrophies.
“At present, retinal prostheses are the most successful approach in this field, and several retinal devices have already been approved for patients with retinal dystrophies (Da Cruz et al., 2016; Stingl et al., 2017).”
From Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects (2020) · cites this paper as Da Cruz et al., 2016
Several research groups are focusing on developing artificial vision approaches based on electric stimulation of the retina.
“several research groups are focusing their efforts on the development of new approaches for artificial vision based on electric stimulation of the retina”
From Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects (2020) · cites this paper as Da Cruz et al., 2016
A multicentre trial of Argus II in end-stage retinitis pigmentosa showed that the device supports basic visual tasks such as grating acuity, high-contrast object localisation, and motion direction detection.
“A multicentre clinical trial of Argus II in patients with end-stage retinitis pigmentosa showed that the device enables basic visual tasks, such as grating visual acuity, high contrast object localisation and detection of direction of motion.”
From Correcting visual loss by genetics and prosthetics (2020) · cites this paper as da Cruz 2016
Argus II durability generally exceeded 5 years, and the best reported grating acuity was about 1.8 logMAR (6/379 Snellen).
“The durability of the device generally exceeded 5 years and the best reported grating visual acuity is around 1.8 logMAR equivalent (6/379 Snellen) [da Cruz 2016; Schaffrath 2019].”
From Correcting visual loss by genetics and prosthetics (2020) · cites this paper as da Cruz 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Interim results from the international trial of Second Sight's visual prosthesis
Humayun, M. S., Dorn, J. D., da Cruz, L., Dagnelie, G., Sahel, J.-A., Stanga, P. E., Cideciyan, A. V., Duncan, J. L., Eliott, D., Filley, E., et al. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.09.028 · Cited by 700 · see citing works
Self-citationSubretinal visual implant alpha IMS - clinical trial interim report
Stingl, K., Bartz-Schmidt, K. U., Besch, D., Chee, C. K., Cottriall, C. L., Gekeler, F., Groppe, M., Jackson, T. L., MacLaren, R. E., Koitschev, A., et al. (2015) · Vision Research · doi:10.1016/j.visres.2015.03.001 · Cited by 387 · see citing works
First-in-human trial of a novel suprachoroidal retinal prosthesis
Ayton, L. N., Blamey, P. J., Guymer, R. H., Luu, C. D., Nayagam, D. A. X., Sinclair, N. C., Shivdasani, M. N., Yeoh, J., McCombe, M. F., Briggs, R. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115239 · Cited by 333 · see citing works
Ahuja, A. K., Dorn, J. D., Caspi, A., McMahon, M. J., Dagnelie, G., daCruz, L., Stanga, P., Humayun, M. S., Greenberg, R. J., & Argus II Study Group (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.179622 · Cited by 289 · see citing works
Self-citationLong-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind
Ho, A. C., Humayun, M. S., Dorn, J. D., da Cruz, L., Dagnelie, G., Handa, J. T., Barale, P. O., Sahel, J., Stanga, P. E., Hafezi, F., et al. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.04.032 · Cited by 262 · see citing works
Self-citationDorn, J. D., Ahuja, A. K., Caspi, A., da Cruz, L., Dagnelie, G., Sahel, J.-A., Greenberg, R. J., McMahon, M. J., & Argus II Study Group, F. T. (2013) · JAMA Ophthalmology · doi:10.1001/2013.jamaophthalmol.221 · Cited by 177 · see citing works
Self-citationGeruschat, D. R., Richards, T. P., Arditi, A., Cruz, L., Dagnelie, G., Dorn, J. D., Duncan, J. L., Ho, A. C., Olmos de koo, L. C., Sahel, J., et al. (2016) · Clinical and Experimental Optometry · doi:10.1111/cxo.12359 · Cited by 77 · see citing works
Self-citationFLORA™: phase I development of a functional vision assessment for prosthetic vision users
Geruschat, D. R., Flax, M., Tanna, N., Bianchi, M., Fisher, A., Goldschmidt, M., Fisher, L., Dagnelie, G., Deremeik, J., Smith, A., et al. (2015) · Clinical and Experimental Optometry · doi:10.1111/cxo.12242 · Cited by 75 · see citing works
Self-citationAdvances in gene therapy technologies to treat retinitis pigmentosa
Petrs‐Silva, H., & Linden, R. (2013) · Clinical ophthalmology · doi:10.2147/opth.s38041 · Cited by 75 · see citing works
Safety evaluation of “retina implant alpha IMS”—a prospective clinical trial
Kitiratschky, V. B. D., Štingl, K., Wilhelm, B., Peters, T. M., Besch, D., Sachs, H. G., Gekeler, F., Bartz‐Schmidt, K. U., & Zrenner, E. (2014) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-014-2797-x · Cited by 55 · see citing works
Greiman, S. E., Tkach, V. V., Pulis, E. E., Fayton, T. J., & Curran, S. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098453 · Cited by 55 · see citing works
Retinal repair with induced pluripotent stem cells
Alshamekh, S. A., & Goldberg, J. L. (2013) · Translational research · doi:10.1016/j.trsl.2013.11.002 · Cited by 43 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Age-related macular degeneration
Mitchell, P., Liew, G., Gopinath, B., & Wong, T. Y. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31550-2 · Cited by 1,572 · see citing works
Non-syndromic retinitis pigmentosa
Verbakel, S. K., van Huet, R. A. C., Boon, C. J. F., den Hollander, A. I., Collin, R. W. J., Klaver, C. C. W., Hoyng, C. B., Roepman, R., & Klevering, B. J. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.03.005 · Cited by 973 · see citing works
The Argus® II Retinal Prosthesis System
Luo, Y. H.-L., & da Cruz, L. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.09.003 · Cited by 351 · see citing works
Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps
Duncan, J. L., Pierce, E. A., Laster, A., Daiger, S. P., Birch, D. G., Ash, J. D., Iannaccone, A., Flannery, J. G., Sahel, J., Zack, D. J., et al. (2018) · Translational Vision Science & Technology · doi:10.1167/tvst.7.4.6 · Cited by 250 · see citing works
Self-citationAn update on retinal prostheses
Ayton, L. N., Barnes, N., Dagnelie, G., Fujikado, T., Goetz, G., Hornig, R., Jones, B. W., Muqit, M. M. K., Rathbun, D. L., Stingl, K., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.029 · Cited by 223 · see citing works
Self-citationAdvances in retinal prosthesis systems
Bloch, E., Luo, Y., & da Cruz, L. (2019) · Therapeutic Advances in Ophthalmology · doi:10.1177/2515841418817501 · Cited by 201 · see citing works
Edwards, T. L., Cottriall, C. L., Xue, K., Simunovic, M. P., Ramsden, J. D., Zrenner, E., & MacLaren, R. E. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2017.09.019 · Cited by 193 · see citing works
Early and late stage gene therapy interventions for inherited retinal degenerations
Botto, C., Rucli, M., Tekinsoy, M. D., Pulman, J., Sahel, J.-A., & Dalkara, D. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100975 · Cited by 190 · see citing works
Self-citationClinical Perspective: Treating RPE65-Associated Retinal Dystrophy
Maguire, A. M., Bennett, J., Aleman, E. M., Leroy, B. P., & Alemán, T. S. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.11.029 · Cited by 183 · see citing works
Persistent remodeling and neurodegeneration in late-stage retinal degeneration
Pfeiffer, R. L., Marc, R. E., & Jones, B. W. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.004 · Cited by 178 · see citing works
Roska, B., & Sahel, J.-A. (2018) · Nature · doi:10.1038/s41586-018-0076-4 · Cited by 161 · see citing works
Self-citationRecent Progress in Wireless Sensors for Wearable Electronics
Park, Y., Lee, S.-I., & Park, J. (2019) · Sensors · doi:10.3390/s19204353 · Cited by 161 · see citing works
A model of ganglion axon pathways accounts for percepts elicited by retinal implants
Beyeler, M., Nanduri, D., Weiland, J. D., Rokem, A., Boynton, G. M., & Fine, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-45416-4 · Cited by 143 · see citing works
Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses
Jiang, L., Lu, G., Zeng, Y., Sun, Y., Kang, H., Burford, J. L., Gong, C., Humayun, M. S., Chen, Y., & Zhou, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-31599-4 · Cited by 154 · see citing works
Self-citationElectronic retinal implants and artificial vision: journey and present
Mills, J. O., Jalil, A., & Stanga, P. E. (2017) · Eye · doi:10.1038/eye.2017.65 · Cited by 133 · see citing works
Self-citationGauvain, G., Akolkar, H., Chaffiol, A., Arcizet, F., Khoei, M. A., Desrosiers, M., Jaillard, C., Caplette, R., Marre, O., Bertin, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01594-w · Cited by 131 · see citing works
Self-citationBrain Machine Interfaces for Vision Restoration: The Current State of Cortical Visual Prosthetics
Niketeghad, S., & Pouratian, N. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0660-1 · Cited by 128 · see citing works
Hirami, Y., Mandai, M., Sugita, S., Maeda, A., Maeda, T., Yamamoto, M., Uyama, H., Yokota, S., Fujihara, M., Igeta, M., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.11.004 · Cited by 124 · see citing works
Development of visual Neuroprostheses: trends and challenges.
Fernandez, E. (2018) · Bioelectronic Medicine · doi:10.1186/s42234-018-0013-8 · Cited by 114 · see citing works
The primate model for understanding and restoring vision
Picaud, S. A., Dalkara, D., Marazova, K., Goureau, O., Roska, B., & Sahel, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902292116 · Cited by 114 · see citing works
Self-citationChenais, N. A. L., Airaghi Leccardi, M. J. I., & Ghezzi, D. (2021) · Communications Materials · doi:10.1038/s43246-021-00133-2 · Cited by 110 · see citing works
Emerging Encapsulation Technologies for Long-Term Reliability of Microfabricated Implantable Devices
Ahn, S.-H., Jeong, J., & Kim, S. J. (2019) · Micromachines · doi:10.3390/mi10080508 · Cited by 109 · see citing works
A review of IoT systems to enable independence for the elderly and disabled individuals
Pérez, A. J., Siddiqui, F. A., Zeadally, S., & Lane, D. R. (2022) · Internet of Things · doi:10.1016/j.iot.2022.100653 · Cited by 107 · see citing works
Beyeler, M., Rokem, A., Boynton, G. M., & Fine, I. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa795e · Cited by 102 · see citing works
Zeng, Q., & Huang, Z. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202301223 · Cited by 103 · see citing works
Fujikado, T., Kamei, M., Sakaguchi, H., Kanda, H., Endo, T., Hirota, M., Morimoto, T., Nishida, K., Kishima, H., Terasawa, Y., et al. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-20367 · Cited by 101 · see citing works
Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
Ding, S. L. S., Kumar, S. S., & Mok, P. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081406 · Cited by 90 · see citing works
Leveraging Zebrafish to Study Retinal Degenerations
Angueyra, J. M., & Kindt, K. S. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00110 · Cited by 82 · see citing works
Erickson-Davis, C., & Korzybska, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0229189 · Cited by 83 · see citing works
LaVail, M. M., Nishikawa, S., Steinberg, R. H., Naash, M. I., Duncan, J. L., Trautmann, N., Matthes, M. T., Yasumura, D., Lau-Villacorta, C., Chen, J., et al. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.10.023 · Cited by 83 · see citing works
Self-citationMolecular Therapies for Inherited Retinal Diseases—Current Standing, Opportunities and Challenges
Vázquez-Domínguez, I., Garanto, A., & Collin, R. W. J. (2019) · Genes · doi:10.3390/genes10090654 · Cited by 80 · see citing works
Bioengineering strategies for restoring vision
Cehajic-Kapetanovic, J., Singh, M. S., Zrenner, E., & MacLaren, R. E. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00836-4 · Cited by 79 · see citing works
Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development
Wu, K. Y., Kulbay, M., Toameh, D., Xu, A. Q., Kalevar, A., & Tran, S. D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020685 · Cited by 81 · see citing works
A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
Adak, S., Magdalene, D., Deshmukh, S., Das, D., & Jaganathan, B. G. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10090-x · Cited by 78 · see citing works
Varela, M. D., de Guimarães, T. A. C., Georgiou, M., & Michaelides, M. (2021) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2020-318483 · Cited by 74 · see citing works
Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa
Meng, D., Ragi, S. D., & Tsang, S. H. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.012 · Cited by 72 · see citing works
Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
Sharma, A. K., & Jaganathan, B. G. (2021) · Biologics · doi:10.2147/btt.s290331 · Cited by 74 · see citing works
Retinitis Pigmentosa: Review of Current Treatment
Wang, A. L., Knight, D. K., Vu, T.-T. T., & Mehta, M. C. (2018) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000256 · Cited by 73 · see citing works
Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve
Gaillet, V., Cutrone, A., Artoni, F., Vagni, P., Mega Pratiwi, A., Romero, S. A., Lipucci Di Paola, D., Micera, S., & Ghezzi, D. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0446-8 · Cited by 73 · see citing works
Visual prosthesis: interfacing stimulating electrodes with retinal neurons to restore vision.
Barriga-Rivera, A., Bareket, L., Goding, J., Aregueta-Robles, U. A., & Suaning, G. J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00620 · Cited by 73 · see citing works
Finn, A., Grewal, D., & Vajzovic, L. (2018) · Clinical ophthalmology · doi:10.2147/opth.s137525 · Cited by 71 · see citing works
Long-term recording reliability of liquid crystal polymer <i>µ</i> ECoG arrays
Woods, V., Trumpis, M., Bent, B., Palopoli-Trojani, K., Chiang, C.-H., Wang, C., Yu, C., Insanally, M. N., Froemke, R. C., & Viventi, J. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aae39d · Cited by 63 · see citing works
Nonsyndromic Retinitis Pigmentosa Overview
Fahim, A. T., Daiger, S. P., & Weleber, R. G. (2017) · Europe PMC (PubMed Central) · Cited by 70 · see citing works
Emerging approaches for restoration of hearing and vision
Kleinlogel, S., Vogl, C., Jeschke, M., Neef, J., & Moser, T. (2020) · Physiological Reviews · doi:10.1152/physrev.00035.2019 · Cited by 68 · see citing works
MRI safety and devices: An update and expert consensus
Maralani, P. J., Schieda, N., Hecht, E. M., Litt, H. I., Hindman, N. M., Heyn, C., Davenport, M. S., Zaharchuk, G., Hess, C. P., & Weinreb, J. C. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26909 · Cited by 67 · see citing works
Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration
Wu, K. Y., Mina, M., Sahyoun, J.-Y., Kalevar, A., & Tran, S. D. (2023) · Sensors · doi:10.3390/s23135782 · Cited by 65 · see citing works
A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: Interim Clinical Trial Results
Petoe, M. A., Titchener, S. A., Kolic, M., Kentler, W. G., Abbott, C. J., Nayagam, D. A. X., Baglin, E. K., Kvansakul, J., Barnes, N., Walker, J. G., et al. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.10.12 · Cited by 63 · see citing works
Cheng, D. L., Greenberg, P. B., & Borton, D. A. (2017) · Current Eye Research · doi:10.1080/02713683.2016.1270326 · Cited by 63 · see citing works
Neurolight: A Deep Learning Neural Interface for Cortical Visual Prostheses
Lozano, A., Suárez, J. S., Soto-Sánchez, C., Garrigós, J., Martínez-Alvarez, J. J., Ferrández, J. M., & Fernández, E. (2020) · International Journal of Neural Systems · doi:10.1142/s0129065720500458 · Cited by 57 · see citing works
POLYRETINA restores light responses in vivo in blind Göttingen minipigs
Vagni, P., Airaghi Leccardi, M. J. I., Vila, C.-H., Zollinger, E. G., Sherafatipour, G., Wolfensberger, T. J., & Ghezzi, D. (2022) · Nature Communications · doi:10.1038/s41467-022-31180-z · Cited by 62 · see citing works
Emerging ultrasonic bioelectronics for personalized healthcare
Jiang, L., & Wu, J. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101110 · Cited by 59 · see citing works
Rebuilding the Missing Part—A Review on Photoreceptor Transplantation
Santos‐Ferreira, T., Borsch, O., & Ader, M. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00105 · Cited by 59 · see citing works
Jacobson, S. G., Cideciyan, A. V., Sumaroka, A., Román, A. J., Charng, J., Lu, M., Choi, W., Sheplock, R., Świder, M., Kosyk, M. S., et al. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-21560 · Cited by 59 · see citing works
Self-citationNew Vision for Visual Prostheses
Farnum, A., & Pelled, G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00036 · Cited by 58 · see citing works
Contemporary approaches to visual prostheses
Mirochnik, R. M., & Pezaris, J. S. (2019) · Military Medical Research · doi:10.1186/s40779-019-0206-9 · Cited by 58 · see citing works
Translation of neurotechnologies
Schalk, G., Brunner, P., Allison, B. Z., Soekadar, S., Guan, C.-T., Denison, T., Rickert, J., & Miller, K. J. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00185-2 · Cited by 45 · see citing works
pulse2percept: A Python-based simulation framework for bionic vision
Beyeler, M., Boynton, G., Fine, I., & Rokem, A. (2017) · Proceedings of the 16th Python in Science Conference · doi:10.25080/shinma-7f4c6e7-00c · Cited by 56 · see citing works
Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography
Jauregui, R., Park, K. S., Duong, J., Mahajan, V. B., & Tsang, S. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-31488-1 · Cited by 55 · see citing works
High resolution optical coherence elastography of retina under prosthetic electrode
Li, R., Du, Z., Qian, X., Li, Y., Martínez-Camarillo, J.-C., Jiang, L., Humayun, M. S., Chen, Z., & Zhou, Q. (2020) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-20-1137 · Cited by 54 · see citing works
Self-citationYang, R., Zhao, P., Wang, L., Feng, C., Chen, P., Wang, Z., Zhang, Y., Shen, M., Shi, K., Weng, S.-J., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01137-8 · Cited by 53 · see citing works
How is flexible electronics advancing neuroscience research?
Chen, Y., Rommelfanger, N. J., Mahdi, A. I., Wu, X., Keene, S. T., Obaid, A., Salleo, A., Wang, H., & Hong, G. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120559 · Cited by 52 · see citing works
Regenerative medicine in the retina: from stem cells to cell replacement therapy
Oswald, J., & Baranov, P. Y. (2018) · Therapeutic Advances in Ophthalmology · doi:10.1177/2515841418774433 · Cited by 51 · see citing works
Bionic eye review - An update.
Nowik, K., Langwińska-Wośko, E., Skopiński, P., Nowik, K. E., & Szaflik, J. P. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.05.041 · Cited by 49 · see citing works
Caspi, A., Roy, A., Wuyyuru, V., Rosendall, P. E., Harper, J. W., Katyal, K. D., Barry, M. P., Dagnelie, G., & Greenberg, R. J. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.17-22377 · Cited by 47 · see citing works
Self-citationSubretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD
Holz, F. G., Mer, Y. L., Muqit, M. M. K., Kuhli-Hattenbach, C., Cusumano, A., Grisanti, S., Kodjikian, L., Pileri, M., Matonti, F., Souied, E. H., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2501396 · Cited by 53 · see citing works
Self-citationPennesi, M. E., Birch, D. G., Duncan, J. L., Bennett, J., & Girach, A. (2019) · Retina · doi:10.1097/iae.0000000000002553 · Cited by 45 · see citing works
Self-citationOne-Year Safety and Performance Assessment of the Argus II Retinal Prosthesis: A Postapproval Study
Schaffrath, K., Schellhase, H., Walter, P., Augustin, A., Chizzolini, M., Kirchhof, B., Grisanti, S., Wiedemann, P., Szurman, P., Richard, G., et al. (2019) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2019.1476 · Cited by 44 · see citing works
Self-citationThe Argus-II Retinal Prosthesis Implantation; From the Global to Local Successful Experience
Farvardin, M., Afarid, M., Attarzadeh, A., Johari, M., Mehryar, M., Nowroozzadeh, M. H., Rahat, F., Peyvandi, H., Farvardin, R., & Nami, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00584 · Cited by 43 · see citing works
Contrast sensitivity deficits in patients with mutation-proven inherited retinal degenerations
Alahmadi, B. O., Omari, A. A., Abalem, M. F., Andrews, C., Schlegel, D., Branham, K. E. H., Khan, N., Fahim, A. T., & Jayasundera, T. (2018) · BMC Ophthalmology · doi:10.1186/s12886-018-0982-0 · Cited by 43 · see citing works
A head mounted device stimulator for optogenetic retinal prosthesis
Soltan, A., Barrett, J. M., Maaskant, P. P., Armstrong, N., Al‐Atabany, W., Chaudet, L., Neil, M. A. A., Sernagor, E., & Degenaar, P. A. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aadd55 · Cited by 41 · see citing works
Fernández, E., Alfaro, A., & González-López, P. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00681 · Cited by 35 · see citing works
The Burden of X-Linked Retinitis Pigmentosa on Patients and Society: A Narrative Literature Review
Chivers, M., Li, N., Pan, F., Wieffer, H., Slowik, R., & Leartsakulpanitch, J. (2021) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s297287 · Cited by 40 · see citing works
Gene Therapy for Inherited Retinal Diseases: From Laboratory Bench to Patient Bedside and Beyond
Brar, A. S., Parameswarappa, D. C., Takkar, B., Narayanan, R., Jalali, S., Mandal, S., Fujinami, K., & Padhy, S. K. (2023) · Ophthalmology and Therapy · doi:10.1007/s40123-023-00862-2 · Cited by 41 · see citing works
Neurophysiology and neural engineering: a review
Procházka, A. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00149.2017 · Cited by 38 · see citing works
First Human Results With the 256 Channel Intelligent Micro Implant Eye (IMIE 256)
Xu, H., Zhong, X., Pang, C., Zou, J., Chen, W., Wang, X., Li, S., Hu, Y., Sagan, D. S., Weiss, P. T., et al. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.10.14 · Cited by 39 · see citing works
Self-citationNeural Prosthetics: A Review of Empirical vs. Systems Engineering Strategies
Loeb, G. E. (2018) · Applied Bionics and Biomechanics · doi:10.1155/2018/1435030 · Cited by 37 · see citing works
Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution
Qian, X., Lu, G., Thomas, B. B., Li, R., Chen, X., Shung, K. K., Humayun, M. S., & Zhou, Q. (2022) · BME Frontiers · doi:10.34133/2022/9829316 · Cited by 37 · see citing works
Self-citationNovel graphene electrode for retinal implants: an in vivo biocompatibility study
Nguyen, D., Valet, M., Dégardin, J., Boucherit, L., Illa, X., de la Cruz, J., del Corro, E., Bousquet, J., Garrido, J. A., Hébert, C., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.615256 · Cited by 36 · see citing works
Safety Studies for a 44-Channel Suprachoroidal Retinal Prosthesis: A Chronic Passive Study
Abbott, C. J., Nayagam, D. A. X., Luu, C. D., Epp, S. B., Williams, R. A., Rosa, C. M. S.-L., Villalobos, J., McGowan, C. C., Shivdasani, M. N., Burns, O., et al. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-23086 · Cited by 36 · see citing works
Depicting brighter possibilities for treating blindness
Sahel, J., Bennett, J., & Roska, B. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax2324 · Cited by 35 · see citing works
Self-citationSahel, J., Grieve, K. F., Pagot, C., Authié, C., Mohand‐Saïd, S., Pâques, M., Audo, I. S., Becker, K., Chaumet-Riffaud, A.-E., Azoulay-Sebban, L., et al. (2021) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2021.04.013 · Cited by 34 · see citing works
Self-citationRetinal cadherins and the retinal cadherinopathies: Current concepts and future directions
Yusuf, I. H., Garrett, A. M., MacLaren, R. E., & Issa, P. C. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101038 · Cited by 35 · see citing works
Progress in artificial vision through suprachoroidal retinal implants
Bareket, L., Barriga‐Rivera, A., Zapf, M. P., Lovell, N. H., & Suaning, G. J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa6cbb · Cited by 34 · see citing works
Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients
Shim, S., Eom, K., Jeong, J., & Kim, S. J. (2020) · Micromachines · doi:10.3390/mi11050535 · Cited by 34 · see citing works
Paknahad, J., Loizos, K., Lan, Y., Humayun, M. S., & Lazzi, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-84437-w · Cited by 33 · see citing works
Self-citationOvercoming failure: improving acceptance and success of implanted neural interfaces
Dalrymple, A. N., Jones, S. T., Fallon, J. B., Shepherd, R. K., & Weber, D. J. (2025) · Bioelectronic Medicine · doi:10.1186/s42234-025-00168-7 · Cited by 36 · see citing works
Targeting of the NRL Pathway as a Therapeutic Strategy to Treat Retinitis Pigmentosa
Moore, S. M., Skowronska‐Krawczyk, D., & Chao, D. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072224 · Cited by 32 · see citing works
The argus ii retinal prosthesis system
Bloch, E., & da Cruz, L. (2020) · Prosthesis · doi:10.5772/intechopen.84947 · Cited by 31 · see citing works
Implantable bioelectrodes: challenges, strategies, and future directions
Hu, M., Liang, C., & Wang, D. (2023) · Biomaterials Science · doi:10.1039/d3bm01204b · Cited by 31 · see citing works
Creating virtual electrodes with 2D current steering
Spencer, T. C., Fallon, J. B., & Shivdasani, M. N. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aab1b8 · Cited by 31 · see citing works
Yoon, Y. J., Lee, J.-I., Jang, Y. J., An, S., Kim, J. H., Fried, S. I., & Im, M. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.3003345 · Cited by 29 · see citing works
Delyfer, M., Gaucher, D., Govare, M., Cougnard‐Grégoire, A., Korobelnik, J., Ajana, S., Mohand‐Saïd, S., Scheer, S., Studer, F., Dollfus, H., et al. (2017) · Ophthalmology Retina · doi:10.1016/j.oret.2017.08.010 · Cited by 28 · see citing works
Self-citationLi, H., Han, T., Wang, J., Lu, Z., Cao, X., Chen, Y., Li, L., Zhou, C., & Chai, X. (2017) · Information Sciences · doi:10.1016/j.ins.2017.06.014 · Cited by 27 · see citing works
Gregori, N. Z., Callaway, N. F., Hoeppner, C. G., Yuan, A., Rachitskaya, A. V., Feuer, W. J., Ameri, H., Arévalo, J. F., Augustin, A. J., Birch, D. G., et al. (2018) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2018.06.012 · Cited by 27 · see citing works
Self-citationOishi, A., Miyata, M., Numa, S., Otsuka, Y., Oishi, M., & Tsujikawa, A. (2019) · International Journal of Retina and Vitreous · doi:10.1186/s40942-019-0173-z · Cited by 27 · see citing works
Yue, L., Wuyyuru, V., Gonzalez-Calle, A., Dorn, J. D., & Humayun, M. S. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab7c8f · Cited by 26 · see citing works
Self-citationPalanker, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24123-0 · Cited by 27 · see citing works
Highest reported visual acuity after electronic retinal implantation
Cehajic‐Kapetanovic, J., Troelenberg, N., Edwards, T. L., Xue, K., Ramsden, J. D., Stett, A., Zrenner, E., & MacLaren, R. E. (2020) · Acta Ophthalmologica · doi:10.1111/aos.14443 · Cited by 27 · see citing works
pulse2percept: A Python-based simulation framework for bionic visionPreprint
Beyeler, M., Boynton, G. M., Fine, I., & Rokem, A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/148015 · Cited by 27 · see citing works
Graphene Oxide–Based Nanomaterials: An Insight into Retinal Prosthesis
Yang, J., Yu, Z.-Y., Cheng, S.-J., Chung, J. H.-Y., Liu, X., Wu, C., Lin, S., & Chen, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082957 · Cited by 26 · see citing works
- Authors
- da Cruz, L., Dorn, J. D., Humayun, M. S., Dagnelie, G., Handa, J., Barale, P.-O., Sahel, J.-A., Stanga, P. E., Hafezi, F., Safran, A. B., Salzmann, J., Santos, A., Birch, D., Spencer, R., Cideciyan, A. V., de Juan, E., Duncan, J. L., Eliott, D., Fawzi, A., Olmos de Koo, L. C., Ho, A. C., Brown, G., Haller, J., Regillo, C., Del Priore, L. V., Arditi, A., & Greenberg, R. J.
- Affiliations
- Second Sight Medical Products (US)
- University of Southern California (US)
- Johns Hopkins University (US)
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Institut de la Vision (FR)
- Manchester Academic Health Science Centre (GB)
- Centro de Retina Médica y Quirúrgica (MX)
- Retina Foundation of the Southwest (US)
- Texas Retina Associates (United States) (US)
- University of Pennsylvania (US)
- University of California, San Francisco (US)
- Northwestern University (US)
- Wills Eye Hospital (US)
- Lighthouse Guild (US)
- Corresponding author
- Dorn, Jessy D.
- ORCID
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 123
- Issue
- 10
- Pages
- 2248-2254
- ISSN
- 0161-6420 (ISSN-L)
- PMC
- PMC5035591
- OpenAlex
- W2476154117
- Cited by
- 359
- References
- 12
- Citations by year
- 2026: 30 · 2025: 23 · 2024: 20 · 2023: 33 · 2022: 33 · 2021: 45 · 2020: 47 · 2019: 48 · 2018: 41 · 2017: 35 · 2016: 3 · 2015: 1
- FWCI
- 23.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ophthalmology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Institutional Repository of Tecnológico de Monterrey (Tecnológico de Monterrey) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, other-oa)
- Funders
- National Eye Institute (R01EY012893, RC3EY020778)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Health Professions › Occupational Therapy › Assistive Technology in Communication and Mobility
- Keywords
- Argus II, retinal prosthesis, retinitis pigmentosa, outer retinal degeneration, long-term safety, visual function, functional vision, electrode arrays, blind patients, adverse events
- MeSH terms
- Adult, Aged, Blindness, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Prosthesis Design, Retina, Retinitis Pigmentosa, Time Factors, Visual Acuity, Treatment Outcome, Persons with Visual Disabilities, Visual Prosthesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
