Rizo, Josep

Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor

Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F.-F., Sharon, M., Browse, J., et al. (2010) · Nature

Plant Molecular Biology ResearchInsect-Plant Interactions and Control

Cited by 1,497

Synaptotagmin I functions as a calcium regulator of release probability

Fernández-Chacón, R., Königstorfer, A., Gerber, S. H., García, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., & Südhof, T. C. (2001) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 961

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction

Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., & Südhof, T. C. (2011) · Cell

Neuroscience and Neuropharmacology ResearchIon channel regulation and function

Cited by 607

Computed structures of core eukaryotic protein complexes

Humphreys, I. R., Pei, J., Baek, M., Krishnakumar, A., Anishchenko, I., Ovchinnikov, S., Zhang, J., Ness, T. J., Banjade, S., Bagde, S. R., et al. (2021) · Science

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 542

Snares and Munc18 in synaptic vesicle fusion

Rizo, J., & Südhof, T. C. (2002) · Nature Reviews Neuroscience

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 539

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

Ma, C., Li, W., Xu, Y., & Rizo, J. (2011) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 363

The Mad2 spindle checkpoint protein has two distinct natively folded states

Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., & Yu, H. (2004) · Nature Structural & Molecular Biology

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 297

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

Gerber, S. H., Rah, J.-C., Min, S.-W., Liu, X., de Wit, H., Dulubova, I., Meyer, A. C., Rizo, J., Arancillo, M., Hammer, R. E., et al. (2008) · Science

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 294

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

Dulubova, I., Lou, X., Lu, J., Huryeva, I., Alam, A., Schneggenburger, R., Südhof, T. C., & Rizo, J. (2005) · The EMBO Journal

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 289

Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids

Araç, D., Chen, X., Khant, H. A., Ubach, J., Ludtke, S. J., Kikkawa, M., Johnson, A. E., Chiu, W., Südhof, T. C., & Rizo, J. (2006) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 256

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

Shin, O.-H., Lu, J., Rhee, J.-S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., et al. (2010) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 243

A minimal domain responsible for Munc13 activity

Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., Grishin, N. V., Rosenmund, C., & Rizo, J. (2005) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 213

Mechanism of neurotransmitter release coming into focus

Rizo, J. (2018) · Protein Science

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 210

Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1

Rhee, J.-S., Li, L. Y., Shin, O.-H., Rah, J.-C., Rizo, J., Südhof, T. C., & Rosenmund, C. (2005) · Proceedings of the National Academy of Sciences

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 155

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., et al. (2015) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 142

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

Lu, J., Machius, M., Dulubova, I., Dai, H., Südhof, T. C., Tomchick, D. R., & Rizo, J. (2006) · PLoS Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 132

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

Xue, M., Ma, C., Craig, T. K., Rosenmund, C., & Rizo, J. (2008) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 131

A Quaternary SNARE–Synaptotagmin–Ca2+–Phospholipid Complex in Neurotransmitter Release

Dai, H., Shen, N., Araç, D., & Rizo, J. (2007) · Journal of Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 127

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

Xu, J., Camacho, M., Xu, Y., Esser, V., Liu, X., Trimbuch, T., Pan, Y.-Z., Ma, C., Tomchick, D. R., Rosenmund, C., et al. (2017) · eLife

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 119

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

Camacho, M., Basu, J., Trimbuch, T., Chang, S., Pulido-Lozano, C., Chang, S.-S., Duluvova, I., Abo-Rady, M., Rizo, J., & Rosenmund, C. (2017) · Nature Communications

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 95

Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

Voleti, R., Jaczynska, K., & Rizo, J. (2020) · eLife

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 76

Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface

Toulmé, E., Salazar Lázaro, A., Trimbuch, T., Rizo, J., & Rosenmund, C. (2024) · Proceedings of the National Academy of Sciences

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 27

A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release

Jaczynska, K., Esser, V., Xu, J., Sari, L., Lin, M. M., Rosenmund, C., & Rizo, J. (2025) · Proceedings of the National Academy of Sciences

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 13

Control of Munc13-1 Activity by Autoinhibitory Interactions Involving the Variable N-terminal Region

Xu, J., Esser, V., Gołębiowska-Mendroch, K., Bolembach, A. A., & Rizo, J. (2024) · Journal of Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 8