Ley, Ruth E.

Host genetic variation impacts microbiome composition across human body sites

Blekhman, R., Goodrich, J. K., Huang, K., Sun, Q., Bukowski, R., Bell, J. T., Spector, T. D., Keinan, A., Ley, R. E., Gevers, D., et al. (2015) · Genome Biology

Gut microbiota and healthGenetic Associations and Epidemiology

Cited by 745

The human gut microbiome: ecology and recent evolutionary changes

Walter, J., & Ley, R. (2011) · Annual Review of Microbiology

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 720

Conducting a microbiome study

Goodrich, J. K., Di Rienzi, S. C., Poole, A. C., Koren, O., Walters, W. A., Caporaso, J. G., Knight, R., & Ley, R. E. (2014) · Cell

Gut microbiota and healthMicrobial Community Ecology and Physiology

Cited by 714

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

Carvalho, F. A., Koren, O., Goodrich, J. K., Johansson, M. E. V., Nalbantoglu, I., Aitken, J. D., Su, Y., Chassaing, B., Walters, W. A., González, A., et al. (2012) · Cell Host & Microbe

Gut microbiota and healthInflammatory Bowel Disease

Cited by 548

A Guide to Enterotypes across the Human Body: Meta-Analysis of Microbial Community Structures in Human Microbiome Datasets

Koren, O., Knights, D., Gonzalez, A., Waldron, L., Segata, N., Knight, R., Huttenhower, C., & Ley, R. E. (2013) · PLoS Computational Biology

Gut microbiota and healthMicrobial Community Ecology and Physiology

Cited by 508

Signatures of early frailty in the gut microbiota

Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D., & Steves, C. J. (2016) · Genome Medicine

Gut microbiota and healthFrailty in Older Adults

Cited by 436

Responses of gut microbiota to diet composition and weight loss in lean and obese mice

Ravussin, Y., Koren, O., Spor, A., LeDuc, C., Gutman, R., Stombaugh, J., Knight, R., Ley, R. E., & Leibel, R. L. (2012) · Obesity

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 406

Development of the human gastrointestinal microbiota and insights from high-throughput sequencing

Dominguez-Bello, M. G., Blaser, M. J., Ley, R. E., & Knight, R. (2011) · Gastroenterology

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 405

Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes

Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E. (2017) · Journal of Molecular Medicine

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 389

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Chassaing, B., Compher, C., Bonhomme, B., Liu, Q., Tian, Y., Walters, W., Nessel, L., Delaroque, C., Hao, F., Gershuni, V., et al. (2022) · Gastroenterology

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 347

Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice

Chassaing, B., Ley, R. E., & Gewirtz, A. T. (2014) · Gastroenterology

Gut microbiota and healthImmune Response and Inflammation

Cited by 326

The Relationship Between the Human Genome and Microbiome Comes into View

Goodrich, J. K., Davenport, E. R., Clark, A. G., & Ley, R. E. (2017) · Annual Review of Genetics

Gut microbiota and healthGenetic Associations and Epidemiology

Cited by 311

Codiversification of gut microbiota with humans

Suzuki, T. A., Fitzstevens, J. L., Schmidt, V. T., Enav, H., Huus, K. E., Mbong Ngwese, M., Grießhammer, A., Pfleiderer, A., Adegbite, B. R., Zinsou, J. F., et al. (2022) · Science

Gut microbiota and healthGenomics and Phylogenetic Studies

Cited by 210

Gut-Microbiota-Metabolite Axis in Early Renal Function Decline

Barrios, C., Beaumont, M., Pallister, T., Villar, J., Goodrich, J. K., Clark, A., Pascual, J., Ley, R. E., Spector, T. D., Bell, J. T., et al. (2015) · PLOS ONE

Gut microbiota and healthChronic Kidney Disease and Diabetes

Cited by 175

Syntrophy via Interspecies H 2 Transfer between Christensenella and Methanobrevibacter Underlies Their Global Cooccurrence in the Human Gut

Ruaud, A., Esquivel-Elizondo, S., de la Cuesta-Zuluaga, J., Waters, J. L., Angenent, L. T., Youngblut, N. D., & Ley, R. E. (2020) · mBio

Gut microbiota and healthAnaerobic Digestion and Biogas Production

Cited by 149

Probiotics, prebiotics, and the host microbiome: the science of translation

Petschow, B., Doré, J., Hibberd, P., Dinan, T., Reid, G., Blaser, M., Cani, P. D., Degnan, F. H., Foster, J., Gibson, G., et al. (2013) · Annals of the New York Academy of Sciences

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 124

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5

Clasen, S. J., Bell, M. E. W., Lee, D.-H., Henseler, Z. M., Borbón, A., de la Cuesta-Zuluaga, J., Parys, K., Zou, J., Youngblut, N. D., Gewirtz, A. T., et al. (2022) · Science Immunology

Immune Response and InflammationGut microbiota and health

Cited by 117

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation

Leifer, C. A., McConkey, C., Li, S., Chassaing, B., Gewirtz, A. T., & Ley, R. E. (2014) · Immunology Letters

Immune Response and InflammationGut microbiota and health

Cited by 34

In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier

Rytter, H., Naimi, S., Wu, G., Lewis, J., Duquesnoy, M., Vigué, L., Tenaillon, O., Belda, E., Vazquez-Gomez, M., Touly, N., et al. (2025) · Gut

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 19

An integrated systems biology approach reveals differences in formate metabolism in the genus Methanothermobacter

Casini, I., McCubbin, T., Esquivel-Elizondo, S., Luque, G. G., Evseeva, D., Fink, C., Beblawy, S., Youngblut, N. D., Aristilde, L., Huson, D. H., et al. (2023) · iScience

Microbial Metabolic Engineering and BioproductionAnaerobic Digestion and Biogas Production

Cited by 14

Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption

Daniel, N., Wu, G. D., Walters, W., Compher, C., Ni, J., Delaroque, C., Albenberg, L., Ley, R. E., Patterson, A. D., Lewis, J. D., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 14