Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes
Open accessAbstract
Bacterial species composition in the gut has emerged as an important factor in obesity and its related metabolic diseases such as type 2 diabetes. Out of thousands of bacterial species-level phylotypes inhabiting the human gut, the majority belong to two dominant phyla, the Bacteroidetes and Firmicutes. Members of the Bacteroidetes in particular have been associated with human metabolic diseases. However, their associations with disease are not always consistent between studies. Delving deeper into the diversity within the Bacteroidetes reveals a vast diversity in genomes and capacities, which partly explain how not all members respond equally to similar environmental conditions in their hosts. Here, we discuss the Bacteroidetes phylum, associations of its members with metabolic phenotypes, and efforts to characterize functionally their interactions with their hosts. Harnessing the Bacteroidetes to promote metabolic health will require a nuanced understanding of how specific strains interact with their microbial neighbors and their hosts under various conditions.
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Mechanisms by which specific members of the microbiota, such as Firmicutes and Bacteroidetes, can affect human phenotypes remain to be fully elucidated.
“Further, mechanisms by which specific members of the microbiota, such as Firmicutes and Bacteroidetes, can affect human phenotypes remain to be fully elucidated [85].”
From The athletic gut microbiota (2020) · cites this paper as [85]
CntA/B and yeaW/X contribute to TMA generation by converting carnitine into TMA.
“Additional microbial enzyme systems that contribute to TMA generation are now known to include CntA/B and yeaW/X for conversion of carnitine into TMA226–230.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [227]
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- Authors
- Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E.
- Affiliations
- Cornell University (US)
- Max Planck Institute for Developmental Biology (DE)
- Corresponding author
- Ley, Ruth E.
- Venue
- Journal of Molecular Medicine
- Published
- 2016-11-29
- Volume
- 95
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- PMC
- PMC5187364
- OpenAlex
- W2557717486
- Cited by
- 389
- References
- 54
- Citations by year
- 2026: 27 · 2025: 30 · 2024: 54 · 2023: 50 · 2022: 46 · 2021: 59 · 2020: 47 · 2019: 36 · 2018: 27 · 2017: 11 · 2016: 1 · 2015: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- David and Lucile Packard Foundation (Fellowship in Science and Engineering)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Bacteroidetes, gut microbiota, metabolic disorders, obesity, type 2 diabetes, Firmicutes, bacterial diversity, host-microbe interactions, metabolic health
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diet, Humans, Metabolic Diseases, Bacteroidetes, Host-Pathogen Interactions, Microbiota
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