Grompe, Markus

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine

Mesenchymal stem cell researchHematopoietic Stem Cell Transplantation

Cited by 2,314

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 1,555

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell

DNA Repair MechanismsBlood disorders and treatments

Cited by 1,198

Biallelic Inactivation of BRCA2 in Fanconi Anemia

Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,149

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

Yin, H., Xue, W., Chen, S., Bogorad, R. L., Benedetti, E., Grompe, M., Koteliansky, V., Sharp, P. A., Jacks, T., & Anderson, D. G. (2014) · Nature Biotechnology

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 951

Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

Azuma, H., Paulk, N., Ranade, A., Dorrell, C., Al-Dhalimy, M., Ellis, E., Strom, S., Kay, M. A., Finegold, M., & Grompe, M. (2007) · Nature Biotechnology

Xenotransplantation and immune responseLiver physiology and pathology

Cited by 835

The Fanconi anaemia/BRCA pathway

D'Andrea, A. D., & Grompe, M. (2003) · Nature Reviews Cancer

DNA Repair MechanismsBlood disorders and treatments

Cited by 822

A DNA methylation atlas of normal human cell types

Loyfer, N., Magenheim, J., Peretz, A., Cann, G., Bredno, J., Klochendler, A., Fox-Fisher, I., Shabi-Porat, S., Hecht, M., Pelet, T., et al. (2023) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 656

Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I

Overturf, K., Al-Dhalimy, M., Tanguay, R., Brantly, M., Ou, C.-N., Finegold, M., & Grompe, M. (1996) · Nature Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 549

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

Tarlow, B. D., Pelz, C., Naugler, W. E., Wakefield, L., Wilson, E. M., Finegold, M. J., & Grompe, M. (2014) · Cell Stem Cell

Liver physiology and pathologyMesenchymal stem cell research

Cited by 533

The ploidy conveyor of mature hepatocytes as a source of genetic variation

Duncan, A. W., Taylor, M. H., Hickey, R. D., Hanlon Newell, A. E., Lenzi, M. L., Olson, S. B., Finegold, M. J., & Grompe, M. (2010) · Nature

Liver physiology and pathologyMicrotubule and mitosis dynamics

Cited by 525

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

Lisowski, L., Dane, A. P., Chu, K., Zhang, Y., Cunningham, S. C., Wilson, E. M., Nygaard, S., Grompe, M., Alexander, I. E., & Kay, M. A. (2014) · Nature

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 450

The origin and liver repopulating capacity of murine oval cells

Wang, X., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M., & Grompe, M. (2003) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyMesenchymal stem cell research

Cited by 410

AAV serotype 2 vectors preferentially integrate into active genes in mice

Nakai, H., Montini, E., Fuess, S., Storm, T. A., Grompe, M., & Kay, M. A. (2003) · Nature Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 392

Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice

Grompe, M., al-Dhalimy, M., Finegold, M., Ou, C. N., Burlingame, T., Kennaway, N. G., & Soriano, P. (1993) · Genes & Development

Metabolism and Genetic DisordersAmino Acid Enzymes and Metabolism

Cited by 355

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

Peng, W. C., Logan, C. Y., Fish, M., Anbarchian, T., Aguisanda, F., Álvarez-Varela, A., Wu, P., Jin, Y., Zhu, J., Li, B., et al. (2018) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 331

Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I

Grompe, M., Lindstedt, S., Al-Dhalimy, M., Kennaway, N. G., Papaconstantinou, J., Torres-Ramos, C. A., Ou, C.-N., & Finegold, M. (1995) · Nature Genetics

Metabolism and Genetic DisordersAmino Acid Enzymes and Metabolism

Cited by 312

Diagnosis and treatment of tyrosinemia type I: a US and Canadian consensus group review and recommendations

Chinsky, J. M., Singh, R., Ficicioglu, C., van Karnebeek, C. D. M., Grompe, M., Mitchell, G., Waisbren, S. E., Gucsavas-Calikoglu, M., Wasserstein, M. P., Coakley, K., et al. (2017) · Genetics in Medicine

Metabolism and Genetic DisordersAmino Acid Enzymes and Metabolism

Cited by 247

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., Spitale, R. C., Dai, C., Gu, X., Qu, K., et al. (2016) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 222

Frequent Aneuploidy Among Normal Human Hepatocytes

Duncan, A. W., Hanlon Newell, A. E., Smith, L., Wilson, E. M., Olson, S. B., Thayer, M. J., Strom, S. C., & Grompe, M. (2012) · Gastroenterology

Microtubule and mitosis dynamicsLiver physiology and pathology

Cited by 197

In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration

Matsumoto, T., Wakefield, L., Tarlow, B. D., & Grompe, M. (2020) · Cell Stem Cell

Liver physiology and pathologyCongenital heart defects research

Cited by 194

Large‐scale molecular characterization of adeno‐associated virus vector integration in mouse liver

Nakai, H., Wu, X., Fuess, S., Storm, T. A., Munroe, D., Montini, E., Burgess, S. M., Grompe, M., & Kay, M. A. (2005) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 190

Stem cells versus plasticity in liver and pancreas regeneration

Kopp, J. L., Grompe, M., & Sander, M. (2016) · Nature Cell Biology

Liver physiology and pathologyPancreatic function and diabetes

Cited by 176

The pathophysiology and treatment of hereditary tyrosinemia type 1

Grompe, M. (2001) · Seminars in Liver Disease

Metabolism and Genetic DisordersAmino Acid Enzymes and Metabolism

Cited by 167