Chien, Shu

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews

Cellular Mechanics and InteractionsAtherosclerosis and Cardiovascular Diseases

Cited by 2,280

Molecular basis of the effects of shear stress on vascular endothelial cells

Li, Y.-S. J., Haga, J. H., & Chien, S. (2005) · Journal of Biomechanics

Cellular Mechanics and InteractionsElasticity and Material Modeling

Cited by 904

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences

Hippo pathway signaling and YAP/TAZAtherosclerosis and Cardiovascular Diseases

Cited by 471

RAP2 mediates mechanoresponses of the Hippo pathway

Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., et al. (2018) · Nature

Hippo pathway signaling and YAP/TAZCellular Mechanics and Interactions

Cited by 377

The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle

Hornberger, T. A., Chu, W. K., Mak, Y. W., Hsiung, J. W., Huang, S. A., & Chien, S. (2006) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerMuscle metabolism and nutrition

Cited by 312

Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

Wang, C., Qi, B., Lin, M., Zhang, Z., Makihata, M., Liu, B., Zhou, S., Huang, Y.-H., Hu, H., Gu, Y., et al. (2021) · Nature Biomedical Engineering

Non-Invasive Vital Sign MonitoringUltrasound Imaging and Elastography

Cited by 274

Vascular mechanotransduction

Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews

Cellular Mechanics and InteractionsElasticity and Material Modeling

Cited by 273

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

Marin, T. L., Gongol, B., Zhang, F., Martin, M., Johnson, D. A., Xiao, H., Wang, Y., Subramaniam, S., Chien, S., & Shyy, J. Y.-J. (2017) · Science Signaling

Metabolism, Diabetes, and CancerEpigenetics and DNA Methylation

Cited by 257

Epigenetic regulation: A new frontier for biomedical engineers

Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S. (2017) · Annual Review of Biomedical Engineering

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 163

Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells

Sun, X., Fu, Y., Gu, M., Zhang, L., Li, D., Li, H., Chien, S., Shyy, J. Y.-J., & Zhu, Y. (2016) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchAtherosclerosis and Cardiovascular Diseases

Cited by 109

Salt-induced hypertension in Dahl salt-sensitive rats. Hemodynamics and renal responses.

Simchon, S., Manger, W. M., Carlin, R. D., Peeters, L. L., Rodriguez, J., Batista, D., Brown, T., Merchant, N. B., Jan, K. M., & Chien, S. (1989) · Hypertension

Sodium Intake and HealthBlood Pressure and Hypertension Studies

Cited by 61

AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

Gongol, B., Marin, T., Peng, I.-C., Woo, B., Martin, M., King, S., Sun, W., Johnson, D. A., Chien, S., & Shyy, J. Y.-J. (2013) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerNF-κB Signaling Pathways

Cited by 61

VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia

Zhu, J.-J., Liu, Y.-F., Zhang, Y.-P., Zhao, C.-R., Yao, W.-J., Li, Y.-S., Wang, K.-C., Huang, T.-S., Pang, W., Wang, X.-F., et al. (2017) · Proceedings of the National Academy of Sciences

MicroRNA in disease regulationExtracellular vesicles in disease

Cited by 56