AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

Regulation of chromatin by histone modifications

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PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

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Regulation of pgc-1α, a nodal regulator of mitochondrial biogenesis

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Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

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Regulation of mitochondrial biogenesis

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

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FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatinPreprint

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Transcriptional control of mitochondrial biogenesis: the central role of PGC-1

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Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene

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Uncoupling proteins and the control of mitochondrial reactive oxygen species production

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AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer

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Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

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PCR Based Determination of Mitochondrial DNA Copy Number in Multiple Species

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Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling

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Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

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UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

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Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

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Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

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AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo: Role of 26S Proteasomes

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Shear stress, SIRT1, and vascular homeostasis

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Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo

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The program for processing newly synthesized histones H3.1 and H4

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Mitochondria and Metabolic Homeostasis

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AMP-activated protein kinase phosphorylates transcription factors of the CREB family

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The Gaggle: An open-source software system for integrating bioinformatics software and data sources

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ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites

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Specificity determinants for the AMP‐activated protein kinase and its plant homologue analysed using synthetic peptides

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Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP‐activated protein kinase

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AMPK regulates histone H2B O-GlcNAcylation

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Histone chaperones link histone nuclear import and chromatin assembly

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The PGC-1α-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer

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Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1

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Metformin interacts with AMPK through binding to γ subunit

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AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

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AMP-Activated Protein Kinase α2 Deficiency Affects Cardiac Cardiolipin Homeostasis and Mitochondrial Function

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Human Histone Acetyltransferase 1 Protein Preferentially Acetylates H4 Histone Molecules in H3.1-H4 over H3.3-H4

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Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome

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Analysis of Phosphorylation-Dependent Protein–Protein Interactions of Histone H3

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A HUVEC Line with a Stable Expression of the VEGF121 Gene to Achieve Complete Endothelialization of Blood Conduits

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Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation

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Mitochondrial biogenesis: An update

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Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

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AMPK: restoring metabolic homeostasis over space and time

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Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

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Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells

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Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

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Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction

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AMPK signaling and its targeting in cancer progression and treatment

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Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

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Mitochondrial quality control mechanisms as molecular targets in diabetic heart

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Epigenetic effects of metformin: from molecular mechanisms to clinical implications

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Mitochondrial Biogenesis in Neurons: How and Where

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Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

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A Metabolic Roadmap for Somatic Stem Cell Fate

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Weight loss is a critical factor to reduce inflammation

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Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling

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Molecular Mechanisms and Regulation of Mammalian Mitophagy

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Physical Exercise: A Novel Tool to Protect Mitochondrial Health

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Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice

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Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation

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Mitochondrial function and abnormalities implicated in the pathogenesis of ASD

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Mitochondrial activity in the regulation of stem cell self-renewal and differentiation

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PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

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Uncoupling Protein 2 in Cardiovascular Health and Disease

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mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics

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Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics

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The Role of AMP-Activated Protein Kinase as a Potential Target of Treatment of Hepatocellular Carcinoma

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Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance

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Epigenetic Control of Mitochondrial Function in the Vasculature

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Mitochondrial network remodeling: an important feature of myogenesis and skeletal muscle regeneration

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Mitochondria: The metabolic switch of cellular oncogenic transformation

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Cancer Therapy-Induced Cardiotoxicity—A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy

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SNF1-related protein kinase 1: the many-faced signaling hub regulating developmental plasticity in plants

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Research progress on Sirtuins (SIRTs) family modulators

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Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain–muscle–liver axis to slow down aging and neurodegeneration: a narrative review

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Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review

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Cardiac Autophagy in Sepsis

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AMPK: An Epigenetic Landscape Modulator

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Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging

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Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities

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High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice

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Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

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Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction

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Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

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AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity

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Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer

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Caloric restriction induced epigenetic effects on aging

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Targeting organ-specific mitochondrial dysfunction to improve biological aging

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Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance

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Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells

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A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1α pathway in mice

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The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis

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Landscape of innate immune system transcriptome and acute T cell–mediated rejection of human kidney allografts

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Dietary Supplementation of Methyl Donor l ‐Methionine Alters Epigenetic Modification in Type 2 Diabetes

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Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis

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AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia.

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The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure

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Role of mitochondria in reno-cardiac diseases: A study of bioenergetics, biogenesis, and GSH signaling in disease transition

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Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease

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Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells

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Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)

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Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue

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Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes

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Mitochondria Homeostasis and Oxidant/Antioxidant Balance in Skeletal Muscle—Do Myokines Play a Role?

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The Complex Interplay between Imbalanced Mitochondrial Dynamics and Metabolic Disorders in Type 2 Diabetes

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Spatial control of AMPK signaling at subcellular compartments

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A minireview: Role of AMP-activated protein kinase (AMPK) signaling in obesity-related renal injury

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SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes

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NAD+ centric mechanisms and molecular determinants of skeletal muscle disease and aging

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Epi-Drugs in Heart Failure

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Pharmacological postconditioning with sappanone A ameliorates myocardial ischemia reperfusion injury and mitochondrial dysfunction via AMPK-mediated mitochondrial quality control

Shi, X., Li, Y., Wang, Y., Ding, T., Zhang, X., & Wu, N. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115668 · Cited by 38 · see citing works

Transcription Factor Movement and Exercise-Induced Mitochondrial Biogenesis in Human Skeletal Muscle: Current Knowledge and Future Perspectives

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The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes

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TET2 regulates early and late transitions in exhausted CD8 + T cell differentiation and limits CAR T cell function

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Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy

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Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells

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Expression analysis and function of mitochondrial genome-encoded microRNAs

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Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease

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Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation

Gwon, S. Y., Ahn, J., Jung, C. H., Moon, B., & Ha, T. Y. (2020) · Nutrients · doi:10.3390/nu12041133 · Cited by 35 · see citing works

Endothelial mechanobiology

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Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions

Garcia, P. A. A., Nagarajan, P., & Parthun, M. R. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00843 · Cited by 34 · see citing works

AMPK Enhances Transcription of Selected Nrf2 Target Genes via Negative Regulation of Bach1

Fischhuber, K., Matzinger, M., & Heiß, E. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00628 · Cited by 34 · see citing works

Histone Modifications in NAFLD: Mechanisms and Potential Therapy

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Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification

Li, J., Zhang, Z., Hai, B., & Zhang, Y. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.036 · Cited by 33 · see citing works

From the (Epi)Genome to Metabolism and Vice Versa; Examples from Hematologic Malignancy

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Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review

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Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

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Naja atra Cardiotoxin 3 Elicits Autophagy and Apoptosis in U937 Human Leukemia Cells through the Ca2+/PP2A/AMPK Axis

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Molecular profiling of high-level athlete skeletal muscle after acute endurance or resistance exercise – A systems biology approach

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Sinapic Acid Promotes Browning of 3T3‐L1 Adipocytes via p38 MAPK/CREB Pathway

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Molecular mechanisms in regulation of autophagy and apoptosis in view of epigenetic regulation of genes and involvement of liquid-liquid phase separation

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Enhanced chloroplast-mitochondria crosstalk promotes ambient algal-H2 production

Elman, T., Ho, T. T. H., Milrad, Y., Hippler, M., & Yacoby, I. (2022) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2022.100828 · Cited by 29 · see citing works

Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism

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Reduced purine biosynthesis in humans after their divergence from Neandertals

Stepanova, V. V., Moczulska, K. E., Vacano, G. N., Kurochkin, I., Ju, X.-C., Riesenberg, S., Macak, D., Maričić, T., Dombrowski, L., Schörnig, M., et al. (2021) · eLife · doi:10.7554/elife.58741 · Cited by 26 · see citing works

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

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AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis

Sun, Y., Li, X., Yin, C., Zhang, J., Liang, E., Wu, X., Ni, Y., Arbesman, J., Goding, C. R., & Chen, S. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2595 · Cited by 25 · see citing works

Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease

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Anti-inflammatory mechanisms of cannabinoids: an immunometabolic perspective

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AMPK Targets Involved in Energy Homeostasis and Epigenetic Regulation of Mitochondrial Function-related Genes - eScholarship

Marin, T. (2013)

AMPK Targets Involved in Energy Homeostasis and Epigenetic Regulation of Mitochondrial Function-related Genes

Marin, T. (2013) · eScholarship (California Digital Library)

AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins

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AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

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Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

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