Hyman, Bradley T.

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains

Gui, Y., Marks, J. D., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2020) · Brain Pathology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 126

Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease

West, H. L., William Rebeck, G., & Hyman, B. T. (1994) · Neuroscience Letters

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 125

Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism

Cooper, J. M., Lathuiliere, A., Migliorini, M., Arai, A. L., Wani, M. M., Dujardin, S., Muratoglu, S. C., Hyman, B. T., & Strickland, D. K. (2021) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 122

Mild to moderate Alzheimer dementia with insufficient neuropathological changes

Serrano‐Pozo, A., Qian, J., Monsell, S. E., Blacker, D., Gómez‐Isla, T., Betensky, R. A., Growdon, J. H., Johnson, K. A., Frosch, M. P., Sperling, R. A., et al. (2014) · Annals of Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 120

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro

Nobuhara, C. K., DeVos, S. L., Commins, C., Wegmann, S., Moore, B. D., Roe, A. D., Costantino, I., Frosch, M. P., Pitstick, R., Carlson, G. A., et al. (2017) · The American Journal of Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 120

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

Polydoro, M., Dzhala, V. I., Pooler, A. M., Nicholls, S. B., McKinney, A. P., Sanchez, L., Pitstick, R., Carlson, G. A., Staley, K. J., Spires-Jones, T. L., et al. (2014) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 117

Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

Takeda, S., Commins, C., DeVos, S. L., Nobuhara, C. K., Wegmann, S., Roe, A. D., Costantino, I., Fan, Z., Nicholls, S. B., Sherman, A. E., et al. (2016) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 113

Cerebrospinal fluid levels of amyloid β‐protein in alzheimer's disease: Inverse correlation with severity of dementia and effect of apolipoprotein e genotype

Nitsch, R. M., Rebeck, G. W., Deng, M., Richardson, U. I., Tennis, M., Schenk, D. B., Vigo‐Pelfrey, C., Lieberburg, I., Wurtman, R. J., Hyman, B. T., et al. (1995) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 113

Multisite assessment of NIA‐AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., et al. (2016) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 113

Different tau species lead to heterogeneous tau pathology propagation and misfolding

Dujardin, S., Bégard, S., Caillierez, R., Lachaud, C., Carrier, S., Lieger, S., Gonzalez, J. A., Deramecourt, V., Déglon, N., Maurage, C.-A., et al. (2018) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 109

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

DeVos, S. L., Corjuc, B. T., Commins, C., Dujardin, S., Bannon, R. N., Corjuc, D., Moore, B. D., Bennett, R. E., Jorfi, M., Gonzales, J. A., et al. (2018) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 106

Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly

Chhatwal, J. P., Schultz, A. P., Marshall, G. A., Boot, B., Gomez-Isla, T., Dumurgier, J., LaPoint, M., Scherzer, C., Roe, A. D., Hyman, B. T., et al. (2016) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 106

Distinct Pools of β-Amyloid in Alzheimer Disease–Affected Brain: A Clinicopathologic Study

Steinerman, J. R., Irizarry, M., Scarmeas, N., Raju, S., Brandt, J., Albert, M., Blacker, D., Hyman, B., & Stern, Y. (2008) · Archives of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 104

Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study

Grodstein, F., van Oijen, M., Irizarry, M. C., Rosas, H. D., Hyman, B. T., Growdon, J. H., & De Vivo, I. (2008) · PLoS ONE

Dementia and Cognitive Impairment ResearchTelomeres, Telomerase, and Senescence

Cited by 104

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

Rudinskiy, N., Hawkes, J. M., Betensky, R. A., Eguchi, M., Yamaguchi, S., Spires-Jones, T. L., & Hyman, B. T. (2012) · Nature Neuroscience

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 103

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

Rozkalne, A., Hyman, B. T., & Spires-Jones, T. L. (2011) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 103

Plaque-associated local toxicity increases over the clinical course of Alzheimer disease

Serrano-Pozo, A., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2016) · The American Journal of Pathology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 100

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans

Cukier, H. N., Kunkle, B. W., Vardarajan, B. N., Rolati, S., Hamilton-Nelson, K. L., Kohli, M. A., Whitehead, P. L., Dombroski, B. A., Van Booven, D., Lang, R., et al. (2016) · Neurology Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 100

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia

International FTD-Genomics Consortium (IFGC), Yokoyama, J. S., Karch, C. M., Fan, C. C., Bonham, L. W., Kouri, N., Ross, O. A., Rademakers, R., Kim, J., Wang, Y., et al. (2017) · Acta Neuropathologica

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 99

Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model

Garcia-Alloza, M., Dodwell, S. A., Meyer-Luehmann, M., Hyman, B. T., & Bacskai, B. J. (2006) · Journal of Neuropathology & Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 99

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Noori, A., Mezlini, A. M., Hyman, B. T., Serrano-Pozo, A., & Das, S. (2021) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 98

Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography

Klunk, W. E., Engler, H., Nordberg, A., Bacskai, B. J., Wang, Y., Price, J. C., Bergström, M., Hyman, B. T., Långström, B., & Mathis, C. A. (2003) · Neuroimaging Clinics of North America

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 96

Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease

Desikan, R. S., Cabral, H. J., Fischl, B., Guttmann, C. R. G., Blacker, D., Hyman, B. T., Albert, M. S., & Killiany, R. J. (2009) · American Journal of Neuroradiology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 94

Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo

Cao, L., Schrank, B. R., Rodriguez, S., Benz, E. G., Moulia, T. W., Rickenbacher, G. T., Gomez, A. C., Levites, Y., Edwards, S. R., Golde, T. E., et al. (2012) · Nature Communications

Alzheimer's disease research and treatmentsOlfactory and Sensory Function Studies

Cited by 93