Hainaut, Pierre

TP53 mutations in human cancers: origins, consequences, and clinical use.

Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 2,199

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., & Olivier, M. (2007) · Human Mutation

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 1,598

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature

Genetic Associations and EpidemiologySmoking Behavior and Cessation

Cited by 1,275

The IARC TP53 database: new online mutation analysis and recommendations to users

Olivier, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C., & Hainaut, P. (2002) · Human Mutation

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 1,248

TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes

Petitjean, A., Achatz, M. I. W., Borresen-Dale, A. L., Hainaut, P., & Olivier, M. (2007) · Oncogene

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 884

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

Lambert, J. M. R., Gorzov, P., Veprintsev, D. B., Söderqvist, M., Segerbäck, D., Bergman, J., Fersht, A. R., Hainaut, P., Wiman, K. G., & Bykov, V. J. N. (2009) · Cancer Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 592

Patterns of p53 G->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

Hainaut, P. (2001) · Carcinogenesis

Carcinogens and Genotoxicity AssessmentCancer-related Molecular Pathways

Cited by 375

TP53 and KRAS Mutation Load and Types in Lung Cancers in Relation to Tobacco Smoke: Distinct Patterns in Never, Former, and Current Smokers

Le Calvez, F., Mukeria, A., Hunt, J. D., Kelm, O., Hung, R. J., Tanière, P., Brennan, P., Boffetta, P., Zaridze, D. G., & Hainaut, P. (2005) · Cancer Research

Lung Cancer Treatments and MutationsLung Cancer Research Studies

Cited by 273

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

Bengochea, A., de Souza, M. M., Lefrançois, L., Le Roux, E., Galy, O., Chemin, I., Kim, M., Wands, J. R., Trepo, C., Hainaut, P., et al. (2008) · British Journal of Cancer

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 215

Air pollution and risk of lung cancer in a prospective study in Europe

Vineis, P., Hoek, G., Krzyzanowski, M., Vigna‐Taglianti, F., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., et al. (2006) · International Journal of Cancer

Air Quality and Health ImpactsOccupational and environmental lung diseases

Cited by 183

Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect

Garritano, S., Gemignani, F., Palmero, E. I., Olivier, M., Martel-Planche, G., Le Calvez-Kelm, F., Brugiéres, L., Vargas, F. R., Brentani, R. R., Ashton-Prolla, P., et al. (2010) · Human Mutation

Genetic Associations and EpidemiologyCancer-related Molecular Pathways

Cited by 153

Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

Shepherd, F. A., Lacas, B., Le Teuff, G., Hainaut, P., Jänne, P. A., Pignon, J.-P., Le Chevalier, T., Seymour, L., Douillard, J.-Y., Graziano, S., et al. (2017) · Journal of Clinical Oncology

Lung Cancer Treatments and MutationsLung Cancer Diagnosis and Treatment

Cited by 124

Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging

Ariffin, H., Azanan, M. S., Abd Ghafar, S. S., Oh, L., Lau, K. H., Thirunavakarasu, T., Sedan, A., Ibrahim, K., Chan, A., Chin, T. F., et al. (2017) · Cancer

Childhood Cancer Survivors' Quality of LifeAcute Lymphoblastic Leukemia research

Cited by 99

Tumor necrosis factor (TNF)‐α, soluble TNF receptors and endometrial cancer risk: The EPIC study

Dossus, L., Becker, S., Rinaldi, S., Lukanova, A., Tjønneland, A., Olsen, A., Overvad, K., Chabbert‐Buffet, N., Boutron‐Ruault, M., Clavel‐Chapelon, F., et al. (2011) · International Journal of Cancer

Cancer Risks and FactorsEndometrial and Cervical Cancer Treatments

Cited by 75

Mutant p53 protein, master regulator of human malignancies: A report on the Fifth Mutant p53 Workshop

Blandino, G., Deppert, W., Hainaut, P., Levine, A., Lozano, G., Olivier, M., Rotter, V, Wiman, K., & Oren, M. (2012) · Cell Death & Differentiation

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 34

Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome

Montellier, E., Lemonnier, N., Penkert, J., Freycon, C., Blanchet, S., Amadou, A., Chuffart, F., Fischer, N. W., Achatz, M.-I., Levine, A. J., et al. (2024) · iScience

Cancer-related Molecular PathwaysGenomics and Rare Diseases

Cited by 29

Fine resolution clustering of TP53 variants into functional classes predicts cancer risks and spectra among germline variant carriers

Montellier, E., Lemonnier, N., Penkert, J., Freycon, C., Blanchet, S., Amadou, A., Chuffart, F., Fischer, N., Achatz, M. I., Levine, A., et al. (2023) · iScience

Cancer-related Molecular PathwaysGenomics and Rare Diseases

Cited by 29